Jail-to-Freedom: which shot keeps opioid addiction in check?
NCT ID NCT04408313
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares two long-acting injectable medications—extended-release naltrexone and extended-release buprenorphine—for people with opioid use disorder who are leaving jail. 240 participants from Maryland jails will receive monthly shots for six months after release. The goal is to see which medication helps them stay in treatment and avoid opioid use or overdose.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
extended-release naltrexone and extended-release buprenorphine
What this could lead to
If this trial succeeds, it could show which long-acting medication works better to help people leaving jail stay in treatment and avoid relapse or overdose.
What could go wrong
This is a mid-stage trial with 240 participants, so results may not apply to everyone. Both medications have side effects and may not work for all individuals.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Friends Research Institute
Baltimore, Maryland, 21201, United States