Can rewards and support keep drug users HIV-Free?
NCT ID NCT04738825
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tests a 24-week program called CoMPASS that uses rewards (contingency management) and extra support to help people who inject drugs take PrEP consistently for HIV prevention. About 526 participants with opioid use disorder will be enrolled. Those who don't stick with PrEP after 12 weeks get stepped up to more intensive adherence support. The goal is to see if this approach improves PrEP use and reduces HIV risk behaviors.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Contingency management with stepped care to PrEP adherence and support services (CoMPASS)
What this could lead to
If it works, this could provide an effective way to help people who inject drugs stay on PrEP and lower their HIV risk.
What could go wrong
This is a behavioral intervention study, not a drug trial, so results may vary by individual. The program is complex and may be hard to scale in real-world settings.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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APT
New Haven, Connecticut, 06519, United States
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Apex Community Care. Inc.
Danbury, Connecticut, 06810, United States
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Greater Hartford Harm Reduction Coalition- SWAN
New Haven, Connecticut, 06511, United States
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Liberations Program, Inc
Bridgeport, Connecticut, 06604, United States
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Recovery Network of Programs, Inc
Bridgeport, Connecticut, 06484, United States
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Stanley Street Treatment and Resource Center
Fall River, Massachusetts, 02720, United States