Can rewards and support keep drug users HIV-Free?

NCT ID NCT04738825

Ongoing Prevention Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 14, 2026 · Updated 6 times

Summary

This study tests a 24-week program called CoMPASS that uses rewards (contingency management) and extra support to help people who inject drugs take PrEP consistently for HIV prevention. About 526 participants with opioid use disorder will be enrolled. Those who don't stick with PrEP after 12 weeks get stepped up to more intensive adherence support. The goal is to see if this approach improves PrEP use and reduces HIV risk behaviors.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Contingency management with stepped care to PrEP adherence and support services (CoMPASS)
What this could lead to: If it works, this could provide an effective way to help people who inject drugs stay on PrEP and lower their HIV risk.
What could go wrong: This is a behavioral intervention study, not a drug trial, so results may vary by individual. The program is complex and may be hard to scale in real-world settings.

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Conditions

The condition(s) this trial relates to.

opiate dependence HIV infectious disease prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV PREVENTION PROGRAM OPIOID-USE DISORDER

Contacts and locations

Locations

Apex Community Care. Inc.

Danbury, Connecticut, 06810, United States
Connecticut Harm Reduction Alliance (GHHRC and SWAN)

New Haven, Connecticut, 06511, United States
Liberations Program, Inc

Bridgeport, Connecticut, 06604, United States
Recovery Network of Programs, Inc

Bridgeport, Connecticut, 06484, United States
Stanley Street Treatment and Resource Center

Fall River, Massachusetts, 02720, United States
The APT Foundation (Legion and Long Wharf)

New Haven, Connecticut, 06519, United States

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