Jail-to-Community opioid treatment: monthly shot vs. daily pill
NCT ID NCT06306443
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a monthly extended-release buprenorphine injection works better than daily sublingual tablets for adults with opioid use disorder who are about to be released from jail. 240 participants will be randomly assigned to one of the two treatments while still incarcerated and followed for 12 months after release. The goal is to see which approach reduces opioid relapse and keeps people in treatment longer.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
buprenorphine (extended-release injection and sublingual tablet)
What this could lead to
If it works, this could show that a monthly injection of buprenorphine helps people leaving jail stay in treatment longer and avoid relapse better than daily tablets.
What could go wrong
This is a single open-label study with 240 participants, so results may not apply broadly. Both treatments are already approved, so the main question is which works better in this specific setting.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Baltimore Central Booking & Intake Center
RECRUITINGBaltimore, Maryland, 21202, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Friends Research Institute
RECRUITINGBaltimore, Maryland, 21201, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••