Scientists study why opioid withdrawal hits some harder than others
NCT ID NCT05027919
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study looks at how opioid withdrawal symptoms vary from person to person. Sixty adults with opioid use disorder will go through a medically supervised taper using hydromorphone and lofexidine. Researchers will measure withdrawal severity during the taper and after a naloxone challenge. The goal is to better understand individual differences in withdrawal, which could lead to more personalized treatment approaches.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Hydromorphone, naloxone, lofexidine
What this could lead to
If successful, this could help doctors better predict and manage withdrawal symptoms, making detox more comfortable and personalized.
What could go wrong
This is a small, early-phase study focused on measuring symptoms, not testing a new treatment. Results may not apply to all patients or settings.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of Maryland
RECRUITINGBaltimore, Maryland, 21201, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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