New study tests if office-based methadone keeps more people in opioid addiction treatment than buprenorphine

NCT ID NCT06323824

Recruiting now Disease control Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two medications—methadone and buprenorphine—given in a doctor's office to treat opioid use disorder. Researchers want to see which one helps people stay in treatment longer over 168 days. About 600 adults starting a new treatment episode will take part. The goal is to find better ways to manage opioid addiction and keep people engaged in care.

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Conditions

The condition(s) this trial relates to.

opiate dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OPIOID-USE DISORDER

Contacts and locations

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Locations

Hennepin Healthcare Addiction Medicine
RECRUITING

Minneapolis, Minnesota, 55415, United States

Contact Email: •••••@•••••
Highland Hospital Bridge Clinic at Alameda Health System
RECRUITING

Oakland, California, 94602, United States
Marshall University Division of Addiction Sciences P.R.O.A.C.T
RECRUITING

Huntington, West Virginia, 25703, United States
Officed Based Addiction Treatment Program, Boston Medical Center
RECRUITING

Boston, Massachusetts, 02118, United States
Outpatient Buprenorphine Induction Clinic, University of California, San Francisco
RECRUITING

San Francisco, California, 94103, United States
Rapid Start Clinic, Kaiser Permanente Colorado
RECRUITING

Denver, Colorado, 80205, United States

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