Magic mushroom compound takes on opioid crisis in new trial

NCT ID NCT06786325

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) can help people with opioid use disorder who are already on medication. 36 participants will receive either a high or low dose and be followed for a year. The goal is to see if psilocybin reduces opioid use and improves treatment adherence.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • University of Pennsylvania

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

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