Magic mushroom compound tested as opioid addiction aid
NCT ID NCT06796062
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) can help people with opioid use disorder who continue using illicit opioids even while on methadone. Up to 480 participants will receive either a low (1 mg), medium (20 mg), or high (30 mg) dose. The study measures how many weeks they stay free of illicit opioid use over 24 weeks, along with safety and craving changes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
psilocybin
What this could lead to
If it works, this could point toward a new way to help people with opioid addiction who haven't been helped by standard treatments alone.
What could go wrong
This is a mid-stage trial with only a single dose of psilocybin. It may not show clear benefits, and side effects like anxiety or changes in heart rhythm are possible.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Duke City Recovery Toolbox
RECRUITINGAlbuquerque, New Mexico, 87102, United States
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NYU Langone Health
RECRUITINGNew York, New York, 10016, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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StartCare
RECRUITINGBrooklyn, New York, 11206, United States
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University of New Mexico
RECRUITINGAlbuquerque, New Mexico, 87106, United States
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VIP Community Services, Inc
RECRUITINGThe Bronx, New York, 10457, United States