Brain scans reveal how opioid addiction warps Decision-Making
NCT ID NCT03958474
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed early-phase study looked at how opioid use disorder changes the way people make decisions. Twelve adults with moderate to severe opioid use disorder completed gambling tasks and had brain scans while receiving oxycodone, placebo, or remifentanil. The goal was to understand the brain processes behind poor choices during addiction and withdrawal.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
oxycodone and remifentanil
What this could lead to
If successful, this could help design better treatments for opioid addiction by understanding how the brain makes choices during withdrawal.
What could go wrong
This is a very early, small study with only 12 people, so results may not apply to everyone. It focuses on understanding, not treating, the disorder.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Laboratory of Human Behavioral Pharmacology
Lexington, Kentucky, 40536-0086, United States