Veterans with PTSD and opioid addiction may get relief from drug combo

NCT ID NCT04360681

First seen May 09, 2026 · Last updated May 17, 2026 · Updated 2 times

Summary

This study looked at whether adding lofexidine to the standard opioid treatment buprenorphine can reduce both PTSD symptoms and opioid relapse in veterans. 84 veterans on stable buprenorphine therapy were enrolled. The goal was to see if the combination is safer and more effective than buprenorphine alone for managing both conditions.

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Contacts and locations

Locations

  • Michael E. DeBakey Veterans Affairs Medical Center

    Houston, Texas, 77030, United States

  • South Texas Veterans Health Care System

    San Antonio, Texas, 78229, United States

Conditions

Explore the condition pages connected to this study.