New study tests quick methadone start for fentanyl users
NCT ID NCT06877858
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage study tests whether a faster 'loading dose' of methadone can safely help people with opioid use disorder who use fentanyl. Researchers will enroll 24 adults and compare standard methadone starts to higher initial doses. The main goal is to find a dose that doesn't cause serious side effects like heavy sedation or breathing trouble.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Methadone hydrochloride (methadone)
What this could lead to
If this works, it could point toward a safer, faster way to start methadone treatment for people who use fentanyl, potentially reducing withdrawal and overdose risk.
What could go wrong
This is a very early, small phase 1 study with only 24 participants. The main goal is safety, not effectiveness, and the approach may not work or could cause side effects like sedation or breathing problems.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Email: •••••@•••••
Locations
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Penn Center for Studies of Addiction (CSA)
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••