New study tests quick methadone start for fentanyl users

NCT ID NCT06877858

Recruiting now Disease control Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage study tests whether a faster 'loading dose' of methadone can safely help people with opioid use disorder who use fentanyl. Researchers will enroll 24 adults and compare standard methadone starts to higher initial doses. The main goal is to find a dose that doesn't cause serious side effects like heavy sedation or breathing trouble.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Methadone hydrochloride (methadone)
What this could lead to: If this works, it could point toward a safer, faster way to start methadone treatment for people who use fentanyl, potentially reducing withdrawal and overdose risk.
What could go wrong: This is a very early, small phase 1 study with only 24 participants. The main goal is safety, not effectiveness, and the approach may not work or could cause side effects like sedation or breathing problems.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

opiate dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OPIOID USE DISORDER (OUD)

Contacts and locations

Locations

Penn Center for Studies of Addiction (CSA)
RECRUITING

Philadelphia, Pennsylvania, 19104, United States

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