Opiate dependence

This study tests whether peer recovery coaches—people who have personally overcome opioid addiction—can help others with opioid use disorder quit smoking. About 60 adults on medication for opioid use disorder who smoke daily will receive either coaching from a peer coach or stand…

This study will test whether cannabis can reduce the severity of opioid withdrawal and make opioid use safer. One hundred adults with opioid use disorder will live in a hospital for about six weeks. Researchers will give them cannabis and a small dose of opioids to see how their …

This study tests whether offering buprenorphine treatment directly at syringe service programs (SSPs) helps more people start and stay on medication for opioid use disorder compared to referring them elsewhere. About 512 adults who use SSPs and have moderate to severe opioid use …

This early study tests a mobile health program called WINGS+++ for women who use opioids and have experienced intimate partner violence. The program includes three sessions on a tablet or smartphone with videos, exercises, and a peer navigator to help connect to services. Researc…

This study will test whether living in a self-contained, AI-managed community (called a Microcity) can improve mental health and reduce addiction in adults with conditions like autism, ADHD, substance use disorders, and behavioral addictions. Up to 1 million participants will liv…

This study tests whether a new four-session group program, called the First Step Program, can be delivered in hospital settings and help people with substance use disorders. The program combines motivational interviewing, acceptance and commitment therapy, and group support to bo…

This study tests a combination of telehealth, peer support, and medication (buprenorphine) to help people with opioid use disorder stay in treatment after leaving the emergency room. The goal is to reduce repeat overdoses and prevent deaths. About 160 adults who have had an opioi…

This early-phase trial will test the safety and blood levels of an investigational drug called MCAM in 24 healthy adults. Participants will receive a single dose of MCAM or a placebo and be monitored for 8 days. The goal is to find the highest safe dose for future studies on opio…

This pilot study will develop and test a telehealth program designed to help marginalized patients access and stay in treatment for opioid use disorder. Researchers will enroll 60 people—half already in treatment and half not yet in treatment—and provide them with a user-friendly…

This study tests whether adding two FDA-approved cannabinoids—dronabinol (synthetic THC) and epidiolex (CBD)—to standard buprenorphine treatment can help people with opioid use disorder stay in treatment and reduce opioid use. The trial will enroll 40 adults who recently started …

This study tests two behavioral interventions—Behavioral Activation (finding enjoyable activities) and Attendance Reinforcement (vouchers for showing up)—to help people with opioid use disorder stay on buprenorphine treatment for at least 6 months. Researchers will enroll 240 adu…

This study tests a refined computer alert that prompts emergency room doctors to order a consultation with an addiction counselor for patients with opioid use disorder. Researchers will enroll 300 adults with moderate to severe opioid use disorder who visit the ER. The goal is to…

This study tests whether a comprehensive telehealth platform called RecoveryPad helps adults with moderate to severe opioid use disorder start and stay in medication treatment. Researchers will enroll 470 participants and track attendance at treatment appointments within 30 and 9…

This study tests a short case management program for people who have been involuntarily admitted to a psychiatric hospital. The program, designed with input from people who have experienced coercion, provides up to five sessions with a nurse or social worker starting during the h…

This study tests whether completing methadone clinic intake during a hospital stay helps people with opioid use disorder stay connected to treatment after leaving. Researchers will compare usual care (a referral at discharge) to a program where hospital staff complete key steps l…

This study tests whether patient navigation—a series of coaching sessions—helps pregnant women with opioid use disorder stay in treatment and reduce drug use. About 429 pregnant women will be randomly assigned to either usual care or patient navigation, which includes up to 14 se…

This study tests a text- and web-based tool called FamilyCHESS, designed to help people with moderate to severe opioid use disorder begin and stay on medication. The tool also involves a concerned family member or friend who provides support. Researchers will compare outcomes lik…

This study tests whether a virtual session with a peer recovery coach can help incarcerated adults with substance use disorders connect to addiction treatment and recovery resources. About 550 participants in jail will either get the coaching or just standard information. Researc…

This study tests a new care model for veterans with opioid use disorder that combines infectious disease screening and treatment with their usual medication-assisted therapy in a single appointment. The goal is to make it easier for veterans to get tested and treated for infectio…

This study tests a 'rapid restart' approach for people with opioid use disorder who have missed 4-8 doses of methadone. Instead of slowly increasing the dose again, participants may return to their previous stable dose right away. The goal is to see if this method is acceptable a…

This study tests a program called CROSSROADS for adults who recently survived an opioid or stimulant overdose. It combines standard paramedic care with free legal help for issues like housing or benefits. Researchers want to see if this reduces drug use and contact with the crimi…

This study tests whether giving buprenorphine (a medication for opioid addiction) through telemedicine works as well as in-person care. Fifty adults with opioid use disorder will be randomly assigned to either remote or in-person treatment. The main goal is to see how long people…

This early-stage study tests a new oral medication called VK4-116 in 48 healthy adults to see if it is safe and how the body processes it. The drug is being developed as a potential treatment for opioid dependence and opioid use disorder. Participants will receive a single dose o…

This study looks at whether a program called EMPOWER, led by trained peer supporters, can help homeless veterans with substance use or mental health issues stay engaged in care and avoid repeated hospital stays or emergency visits. About 278 veterans in permanent supportive housi…

This pilot study will test whether giving a monthly extended-release buprenorphine injection (BRIXADI) from a mobile pharmacy clinic is acceptable and practical for people with opioid use disorder. About 60 participants will receive the shot for 6 months, and researchers will tra…

This study tests two methods for starting buprenorphine treatment in adults with opioid use disorder who use fentanyl. Participants will be randomly assigned to either a low-dose start or a direct injection approach. The goal is to see which method helps people stay in treatment …

This study will test an app called JomCare that sends personalized support to men who have sex with men when they are most likely to engage in chemsex (using drugs before or during sex). The goal is to reduce risky behaviors and prevent new HIV infections. About 482 HIV-negative …

This study tests a biodegradable implant called OLANI that slowly releases naltrexone to block the effects of opioids for weeks. Researchers will enroll 250 adults with opioid use disorder who have already completed withdrawal. Participants will receive up to four implants over a…

This early-stage trial tests a new naltrexone implant (iSTEP-N) that slowly releases medication over 12 months to block opioids. It will enroll 33 healthy adults and compare two implant doses to standard monthly injections. The goal is to see if the implant can maintain steady dr…

This study tests whether combining ketamine-assisted psychotherapy with mindfulness training (called KetaMORE) helps people with opioid use disorder who are already on medication. 88 participants will be randomly assigned to receive either KetaMORE or ketamine with a support grou…

This study tests whether offering gift cards can help people leaving jail stick with their medication for opioid use disorder. Participants earn up to $600 for attending appointments and counseling over three months after release. The goal is to reduce the high risk of overdose d…

This study tests whether offering medication for opioid use disorder (buprenorphine) in community settings—like churches or social service centers—via telemedicine, plus one-on-one coaching, helps people stay in treatment longer than standard clinic care. About 400 participants w…

This study aims to create personalized treatment plans for people with opioid use disorder by using machine learning to find the best sequence of medications and behavioral therapy. Researchers will test these plans in a small pilot study with 75 adults to see if they are feasibl…

This pilot study tests whether a peer-led program called Yuva Sath can help young people (ages 18-29) who inject drugs stay engaged in substance use treatment and HIV prevention. The program includes six one-on-one sessions with a peer counselor and weekly text check-ins. Researc…

This study will bring medication for addiction and cognitive behavioral therapy to homeless veterans living in VA supportive housing. The goal is to help them stay housed and reduce substance use. About 8,000 veterans across multiple VA sites will take part.

This study tests a behavioral program called contingency management for people with opioid use disorder. Participants in an inpatient unit receive small rewards when they provide drug-free urine samples. The goal is to see if this approach helps them stay abstinent during their t…

This study tests whether a monthly injection of buprenorphine (a medication for opioid dependence) works well and is affordable in low- and middle-income countries. About 760 adults who inject drugs and have opioid dependence will receive the injection and be followed for 48 week…

This study will test a new, non-invasive device that measures blood flow and oxygen levels in the brains of newborn babies. Researchers will compare babies who were exposed to opioids before birth with those who were not. The goal is to see if the device can detect signs of opioi…

This study tests if adding a safe dye to a drink can prove that urine samples are real and not tampered with. About 114 adults with substance use disorder will drink Gatorade with or without the dye, then provide a urine sample 15 minutes later. Researchers will check for the dye…

This study tests whether sending fentanyl test strips by mail and providing online education can reduce opioid overdoses. Researchers will enroll 100 adults who use opioids or stimulants and live in states where test strips are legal. The goal is to find the most effective and lo…

This study aims to help outpatient clinics provide HIV prevention medication (PrEP) and sterile injection equipment to people who inject drugs. Researchers will work with clinics to develop and test a bundle of strategies, including patient education, provider training, and syste…

This study looks at whether long-acting HIV prevention shots and opioid use disorder medications can help people in prison who are about to be released. Researchers will enroll 450 adults at participating prisons and follow them to see if they stick with treatment and avoid HIV, …

This study tests a clinical decision support tool that helps primary care providers safely taper opioid doses in patients. The tool provides guidelines and reminders to reduce withdrawal and overdose risks. About 200,000 patients will be involved, and researchers will compare out…

This study tests a smartphone game called MedSMA℞T Mobile, designed to help parents and their teenage children learn how to use, store, and dispose of opioids safely. About 244 families will play the game for 30 minutes and complete surveys over 9 months. The goal is to see if th…

This study tests whether a social network approach can encourage people who inject drugs to start HIV prevention medication (PrEP) and addiction treatment (MOUD). About 398 participants will be assigned to either the LINKED intervention or a control group. The goal is to see if p…

This study tests whether a ketone supplement drink can reduce cravings and withdrawal symptoms in adults with opioid use disorder who are undergoing detox in a treatment center. Fifty participants will receive either the ketone drink or a placebo three times daily for seven days.…

This trial compares two types of nerve blocks given before breast surgery to see which better prevents chronic pain that can last for months. Women aged 18-65 scheduled for mastectomy will receive either a serratus posterior superior intercostal plane block or an erector spinae p…

This study tests a smartphone app called KIOS designed to help people recovering from opioid addiction manage their health. Researchers will track how well participants stay in treatment over one year and who benefits most from the app. About 134 adults who recently started bupre…

This study looks at whether emergency medical services (EMS) can safely start buprenorphine treatment for people with opioid use disorder right at the scene of an emergency. Researchers will first test how practical and acceptable this approach is, then track whether patients sta…

This study will compare two pain medications, buprenorphine and oxycodone, in about 282 adults with injuries to at least two body areas. The goal is to see which provides better pain control with fewer risks. Participants will receive one of the two drugs as part of a standard pa…

This study tests whether a behavioral method called Emotional Brain Training (EBT) can help people in recovery from addiction manage stress, anxiety, and cravings. About 54 adults receiving standard addiction treatment will either continue their usual care or also attend weekly E…

This study tests whether a type of cognitive training called Action-Based Cognitive Remediation (ABCR) can improve thinking skills in people with various psychiatric conditions like depression, schizophrenia, anxiety, PTSD, and autism. Participants will complete computer exercise…

This study tests whether equine-assisted therapy (working with horses) can improve mental health and reduce cravings in people recovering from addiction. Twenty-two adults who have completed detox will be randomly assigned to either receive 22 sessions of equine therapy over 24 w…

This early-phase trial tests whether combining lidocaine and ketamine can reduce severe cancer-related pain that doesn't respond to opioids. Twenty-four adults will receive two weekly infusions of the drug combination or an active placebo in a blinded, crossover design. The goal …

This early-stage trial will give a single 10 mg dose of psilocybin to 70 adults recovering from trauma surgery who also have opioid use disorder. Researchers want to see if it's safe and practical to give psilocybin in the hospital, and how it affects pain, mood, and opioid use o…

This Phase 3 trial will test a web-based program called IMPACT for 250 veterans who have both opioid use disorder and chronic pain. The program includes 9 online modules and weekly feedback from a coach, all done from home. The goal is to see if it reduces how much pain interfere…

This study will test whether cannabis can reduce the desire to take opioids in people with opioid use disorder. Thirty participants will live in a hospital for six weeks and receive either cannabis or a placebo, along with opioids. Researchers will measure how many times particip…

This study aims to adapt and validate a French version of the Recovery Assessment Scale (RAS), a questionnaire that measures how people feel about their own recovery from mental health conditions. Researchers will ask 260 adult psychiatric patients in France to fill out the RAS a…

This study tests a bundle of smartphone-based tools, including a mobile health app and other online resources, to see if they are practical and helpful for people who use drugs. The goal is to lower overdose risk by improving access to prevention services. Forty participants will…

This study is the first time MG001, a formulation of mitragynine from the kratom plant, is being tested in people. Researchers want to see if it is safe and how the body processes it. About 32 healthy adults who have used oral opioids recently will receive a single dose of MG001 …

This study tests a training program called Project ECHO to help rural jails start or increase use of medications (methadone, buprenorphine, naltrexone) for opioid use disorder. Staff from 40 jails will attend online sessions with experts and peers over 18 months. Researchers will…

This study will test whether a mobile app that teaches people about how addiction affects the brain is easy to use and acceptable for people receiving medication treatment for opioid or stimulant use disorders. Forty participants will use the app and complete surveys. The goal is…

This pilot study tests a one-time 'booster' session for people who inject drugs and their injecting partners, given right after finishing hepatitis C treatment. The session helps them set health goals, identify barriers, and improve communication to stay engaged in ongoing health…

This study looks at whether adding a clinical pharmacist to community mental health teams (called FACT teams) helps people with severe mental illness and substance use disorders feel better and manage their medications more effectively. About 160 adults will take part, and the st…

This study tests a web-based toolkit that helps healthcare providers screen for intimate partner violence and mental health issues in patients receiving treatment for opioid use disorder. About 792 patients and their providers will use the toolkit during routine care to see if it…

This pilot study tests whether a specially designed family therapy program is practical and well-liked by women who have opioid use disorder and are involved in the justice system. About 120 women and a family member will take part, with some receiving the therapy plus usual care…

This study will observe 60 adults in residential therapeutic communities in Mexico to understand how recovery from substance use unfolds over time. Participants will answer quick mobile surveys several times a day about cravings, mood, and social interactions for 8 to 12 weeks. T…

This study tests whether a special team of doctors, nurses, and peer supporters can help people with substance use disorders get the follow-up care they need after a hospital stay. The team meets patients in the hospital and provides support and treatment after they leave, helpin…

This study tests whether adding a career counseling program called Purposeful Pathways to standard job training helps veterans with mental health and substance use disorders find and keep quality jobs. About 254 veterans from three VA sites will take part. The goal is to improve …

This study tests if a 12-week one-on-one support program is easy to complete and acceptable for people supporting a loved one who recently finished substance use treatment. About 18 participants will attend weekly telehealth sessions and complete surveys and interviews. The goal …

This study looks at whether using a stomach ultrasound before sedation can help anesthesiologists make safer decisions for chronic pain patients. These patients often take opioids or have other conditions that slow stomach emptying, raising the risk of food or liquid entering the…

This study tests whether a computer alert can help doctors identify and treat patients with opioid use disorder. About 200,000 adults will be involved, and doctors will either get an alert or not. The goal is to see if the alert increases the use of medications like buprenorphine…

This study tests a new care system for people with opioid use disorder across the University of Illinois Hospital and Clinics. Researchers want to see if it increases screening, helps patients stay in care, boosts use of addiction medications, and reduces opioid-related deaths. O…

This study tests whether a tool called Compl-AI can predict which adults with opioid use disorder will stop their medication early. Researchers will observe 295 people receiving standard care and track their treatment attendance and adherence. The goal is to see if the model work…

This study will test a tool called the Health Improvement Profile (HIP) in a mental health inpatient unit. The HIP is a checklist that helps clinicians spot physical health problems like high blood pressure or poor diet in people being treated for mental illness. Researchers will…

This study tests whether a coaching program called COSTARS helps child welfare supervisors better support their teams, including caseworkers and peer mentors with lived recovery experience. About 200 supervisors in Ohio's START program will either receive coaching or continue usu…

This study aims to better understand psychiatric disorders, thinking problems, and treatment side effects in 2000 cancer patients and their close relatives. Researchers will compare those with and without mental health issues to find patterns and improve care. No new treatments a…

This study will check how much psychiatric clients know about occupational therapy (OT) and whether their expectations are realistic. It will also evaluate how well OT interns explain health information and conduct interviews. Researchers will develop new tools to measure these s…

This study looks at whether a 50-minute education session can help pregnant and new mothers taking medication for opioid use disorder, along with a friend or family member, learn more about their treatment and newborn withdrawal. Researchers will measure how many women are intere…

This study looks at how stress and brain stimulation affect thinking and opioid cravings in 20 people with opioid use disorder who are not seeking treatment. Participants will receive either real or fake brain stimulation (rTMS) and a stress-inducing drug or placebo. Researchers …

This pilot study will test whether an 8-session telehealth program can help people who inject drugs in the rural South build coping skills and resilience. The goal is to improve access to HIV prevention (PrEP), hepatitis C treatment, and medication for opioid use disorder. The st…

This study will monitor 52 adults after surgery to see if the timing of opioid painkillers affects breathing problems. Participants will wear a noninvasive breathing monitor in the recovery room. The goal is to find a link between when opioids are given and drops in breathing fun…

This study aims to develop and test a program that helps people receiving medication for opioid use disorder connect with recovery community centers. Researchers will enroll 145 adults in Massachusetts who are on buprenorphine treatment. The goal is to see if this program is feas…