Could a low-dose buprenorphine film be a safer painkiller than oxycodone?
NCT ID NCT05988710
First seen Jan 12, 2026 · Last updated Jun 20, 2026 · Updated 28 times
Summary
This study tests whether low-dose buccal buprenorphine (a film placed in the cheek) can provide pain relief similar to a standard dose of oxycodone but with less potential for abuse. 120 healthy adults will receive different doses of buprenorphine, oxycodone, or placebo in separate sessions. Researchers will measure pain tolerance and drug liking to compare the two drugs.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Vanderbilt University Medical Center
RECRUITINGNashville, Tennessee, 37069, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
buprenorphine (buccal) and oxycodone (oral)
What this could lead to
If successful, this could show that low-dose buccal buprenorphine provides pain relief similar to oxycodone but with lower abuse potential, pointing toward a safer painkiller option.
What could go wrong
This is a small, early-phase study in healthy volunteers, not patients with pain. Results may not translate to real-world use, and abuse potential may still be significant.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.