Yale University

This early-phase study is testing the safety of a new two-drug combination (domvanalimab and zimberelimab) for adults with glioblastoma that has returned after initial treatment. The trial will enroll 46 patients to see how well the drugs are tolerated and to study their effects …

This study is testing a new support program led by pharmacists to help women with HIV who face social challenges like housing or food insecurity. The program uses telehealth to help these women switch from daily pills to a long-acting injectable HIV medication and stay on track w…

This study is testing if adding support from a community health worker helps people with type 2 diabetes better use a 'produce prescription' program, which provides funds to buy fruits and vegetables. It focuses on Hispanic adults in Connecticut who are eligible for Medicaid. The…

This study aimed to see if adding the drug etrasimod to standard steroid treatment could better control severe diarrhea and colon inflammation (colitis) caused by powerful cancer immunotherapies. It planned to enroll adults with advanced cancer who developed this serious side eff…

This study is testing if adding a specific type of drug (an SGLT2 inhibitor) to the usual hospital care helps patients who are hospitalized with both sudden heart failure and kidney injury. The main goal is to see if it's practical to run a larger trial by checking if patients ar…

This study is testing an experimental drug called sacituzumab govitecan (IMMU-132) for women whose endometrial cancer has returned or continued growing despite prior chemotherapy. The drug is designed to deliver chemotherapy directly to cancer cells. Researchers will measure how …

This small pilot study is testing a new computer tool called ED-TREAT, designed to help emergency room staff identify patients at risk of becoming agitated and suggest calming techniques early. The goal is to prevent agitation from happening, improving care and safety. The study …

This study aimed to test whether Botox injections could help control hidradenitis suppurativa, a painful skin condition that causes recurring abscesses and nodules. The trial planned to enroll people with active underarm lesions to see if Botox could reduce the number and severit…

This study is testing whether a behavioral weight loss program and a combination medication (naltrexone/bupropion) can help people who struggle with loss-of-control eating after bariatric surgery. It involves 160 adults who are about six months past their surgery and still experi…

This study aims to reduce potentially harmful medication prescriptions for adults 65 and older leaving the emergency room. It tests whether feedback messages from a fellow doctor or an anonymous computer system are more effective than usual care at helping doctors choose safer dr…

This small Yale University study is testing whether apremilast, a medication approved for psoriasis, might help people with alcohol use disorder drink less. Ten participants will take the medication daily and then complete lab sessions where researchers measure how much alcohol t…

This study is testing whether surgically removing the prostate gland, combined with standard hormone-blocking drugs and possibly chemotherapy, works better than drug therapy alone for men newly diagnosed with prostate cancer that has already spread. Researchers want to see if thi…

This small, early-stage study from Yale University is investigating whether psilocybin, the active compound in 'magic mushrooms,' can change brain activity in a way that helps treat major depression. The study involves 18 adults with depression who haven't gotten better with stan…

This study is testing if a drug called Taltz can slow down the growth of scar tissue in the windpipe, a condition called idiopathic subglottic stenosis. The goal is to see if the drug can help patients avoid or delay the need for repeated surgical procedures to keep their airway …

This pilot program aims to improve asthma care for children in the New Haven area. It partners doctors with trained community health workers who provide home visits and connect families to resources. The goal is to see if this team-based approach helps kids manage their asthma be…

This study is testing a custom-modified stent graft for people with dangerous thoracoabdominal aortic aneurysms (TAAAs) who are at high risk for traditional open surgery. The goal is to see if this less invasive procedure is safe and effective compared to open surgery. Researcher…

This study is testing whether a medication called lisdexamfetamine can help people who continue to struggle with binge eating and weight regain after bariatric surgery. It focuses on patients who did not respond well to initial treatments. Researchers will compare the medication …

This study is testing a two-part treatment for pancreatic cancer that has not spread to other organs but cannot be surgically removed. The goal is to see if a specific chemotherapy regimen followed by highly focused radiation can better control the cancer and delay its progressio…

This early pilot study is testing whether temporarily raising a patient's blood pressure during a stroke clot-removal procedure can help protect more brain tissue from damage. The researchers will enroll 40 stroke patients to see if this approach is practical and safe to perform …

This early-stage study is testing the safety and initial effects of a single dose of the medication brexanolone in people who have both PTSD and alcohol use disorder. Researchers want to see if the drug can help reduce drinking triggered by stress. About 25 participants will rece…

This study compares two ways to help people recently released from jail or prison get connected to important health services. It focuses on HIV prevention and treatment, hepatitis C care, and medication for opioid addiction. Researchers will test whether personal guides or mobile…

This study is testing a drug called sacituzumab govitecan in people with ovarian, fallopian tube, or primary peritoneal cancer that has returned and is resistant to standard platinum-based chemotherapy. The goal is to see if this targeted drug can shrink tumors and control the di…

This early-stage study is testing a new three-drug combination for people with advanced melanoma or kidney cancer. The main goal is to find a safe and tolerable dose of the new drug, APX005M, when given with two existing immunotherapy drugs. Researchers will enroll about 26 patie…

This study compares two telehealth support programs for adults with chronic pain who are on long-term opioid therapy. It tests whether adding a virtual self-management coaching program to a standard pharmacist-led care model is more effective. The goal is to help people better ma…

This study is testing whether taking two doses of psilocybin, the active compound in 'magic mushrooms,' can reduce symptoms of obsessive-compulsive disorder (OCD). It involves 30 adults with moderate-to-severe OCD who haven't gotten better with standard medications or therapy. Pa…

This study compares two approaches to help families affected by domestic violence. It looks at whether family-centered care helps caregivers connect better with support services compared to child-centered care. The research involves 200 caregivers whose young children were expose…

This study is testing whether a medication called naltrexone/bupropion can help people maintain control over binge eating and keep weight off after bariatric surgery. It involves 100 adults who had surgery about 10 months ago and initially responded well to treatment for binge ea…

This study is testing whether an experimental drug called BHV-7000 can reduce abnormal brain activity in people with epilepsy who have a special implanted brain device (RNS System). Five participants will take the drug for four weeks, and researchers will compare their brain reco…

This study compares three types of weight loss surgery—gastric band, sleeve gastrectomy, and gastric bypass—in severely obese teenagers. Researchers at Yale University are following 26 adolescents for two years after surgery to see which procedure is safest and most effective at …

This study is testing how well a proven family-based program, called Bright Bodies, works to help children with obesity manage their weight when it's offered in different community settings. Researchers are observing about 180 children, aged 7-13, and their parents as they go thr…

This study aimed to test a computer algorithm designed to scan medical billing records to find patients who might have ATTR amyloidosis but haven't been diagnosed yet. The goal was to see if this tool could accurately identify these hidden cases, helping doctors find and treat pe…

This study is testing whether artificial intelligence (AI) can help doctors find a serious heart valve condition called aortic stenosis earlier. Researchers will use portable heart tests (EKG and ultrasound) on 410 adults aged 70 and older during routine doctor visits. The goal i…

This study is developing and testing a new augmented reality videogame called 'No Time Wasted' to help prevent alcohol-related harm in teenagers. Researchers are working with 20 teens, aged 16-18, to get feedback on the game and then see if playing it changes their knowledge and …

Yale researchers are developing a virtual reality game to prevent middle school students from starting to vape. The game teaches teens skills to manage emotions and resist peer pressure around e-cigarettes. The study is gathering feedback from 8th graders and school staff to see …

This study is testing a new behavioral therapy designed to help teenagers with autism spectrum disorder manage difficult emotions like anger, frustration, and aggression. The therapy involves 15 weekly sessions where teens and their parents learn skills for emotion regulation and…

This study is testing whether a virtual, community-based program combining music, mindfulness, and drum circles can help Black adults manage stress, anxiety, and depression. Researchers want to see if feeling 'in sync' with others during drumming improves feelings of connection a…

This study aimed to see if a TENS device, which uses mild electrical pulses, could help reduce pain during IUD insertion. It planned to compare the real device to a fake one in women getting an IUD. The trial was withdrawn before any participants were enrolled.

This Yale University study is testing whether virtual, community-based programs that combine music and mindfulness can help Black adults manage stress, anxiety, and depression. The research focuses on creating culturally relevant support, an area often overlooked in past studies.…

This study is testing whether a small wearable device that helps improve posture can reduce symptoms of cubital tunnel syndrome, a condition causing pain, numbness, and weakness in the arm and hand. It will compare standard care alone to standard care plus using the posture train…

This Yale University study is exploring whether attending live music concerts can help reduce anxiety and improve emotional connection for people in the early stages of Alzheimer's disease and their caregivers. Researchers will measure brain activity, heart rate, and survey respo…

This study aimed to see if a reflective writing program, already used for medical students, could help reduce burnout in physician assistant (PA) students during their clinical training. Yale PA students would have attended small group workshops to write and share reflections gui…

This study is testing if participating in weekly community drum circles for 8 weeks can help reduce anxiety and increase feelings of connection. It focuses on including Persons of African Descent and other marginalized groups who are often left out of mental health research. Rese…

This study aims to gather information to help doctors better understand which heart artery test works best for women with chest pain. Researchers will follow 500 women for 5 years to compare two different artery pressure measurements taken during heart catheterization. The goal i…

This study aims to better understand why some people experience chest pain and signs of reduced blood flow to the heart, even though their main heart arteries look clear on standard tests. Researchers will observe 500 patients with this condition, using advanced tools during a he…

This study is creating a large international database to collect information from about 8,000 people who had a stroke and later developed seizures (post-stroke epilepsy). Researchers will analyze this data to better understand how seizures affect recovery and to build a tool that…

This study aims to understand how banning menthol flavor in cigarettes and e-cigarettes affects people who currently smoke menthol cigarettes. Researchers are testing whether having menthol e-cigarettes available helps smokers reduce or quit smoking when menthol cigarettes are ba…

This Yale University study is exploring whether a non-invasive brain stimulation technique called rTMS can affect how adults with autism process social information. Researchers will measure brain activity, eye movements, and social task performance before and after a single stimu…

This study aimed to learn if a simple blood test could detect and predict blockages in the small blood vessels of the heart in people who have had a heart transplant. Researchers planned to check blood levels of donor DNA every few months and compare them to heart scan results ov…

This study aims to discover the genetic causes of diseases that weaken the body's main artery (the aorta) and affect the heart's aortic valve. Researchers are collecting blood and tissue samples from 3,000 participants, including patients with these conditions and their family me…

This early-stage study aims to understand how a cannabis-based medication (Dronabinol) affects the immune system and genes in people living with HIV. Researchers will compare 160 participants, both with and without HIV, who have used cannabis before. The goal is to gather basic k…

This study is collecting detailed information from 458 patients with critical limb ischemia, a severe form of leg artery disease that causes extreme pain, non-healing wounds, and high risk of amputation. Researchers are tracking what treatments patients receive and how those trea…