Mystery chest pain: study digs deeper to find hidden heart problems

NCT ID NCT05288361

Ongoing Knowledge-focused Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study involves 500 people who have chest pain or other signs of heart trouble, but whose main heart arteries are not blocked. Researchers use special tools during a heart catheterization to measure tiny blood vessel function and look for hidden causes like microvascular disease or spasms. The goal is to better understand these conditions and track patients' health over time to improve diagnosis and treatment.

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Conditions

The condition(s) this trial relates to.

coronary microvascular disorder coronary vasospasm ischemic disease Microvascular Angina myocardial ischemia nonobstructive coronary artery disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHEST PAIN WITH NORMAL CORONARY ANGIOGRAPHY CORONARY MICROVASCULAR DYSFUNCTION CORONARY VASOSPASM ENDOTHELIAL DYSFUNCTION ISCHEMIA AND NO OBSTRUCTIVE CORONARY ARTERY DISEASE MICROVASCULAR ANGINA

Contacts and locations

Locations

Columbia University Irving Medical Center

New York, New York, 10032, United States
NYU Langone Health

New York, New York, 10010, United States
New York Presbyterian-Brooklyn Methodist Hospital

Brooklyn, New York, 11215, United States
Northeast Georgia Medical Center

Gainesville, Georgia, 30501, United States
Stanford Hospital

Stanford, California, 94305, United States
The Christ Hospital

Cincinnati, Ohio, 45219, United States
Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107, United States
UCLA Health

Los Angeles, California, 90095, United States
Yale New Haven Hospital

New Haven, Connecticut, 06520, United States

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