Yale University

This study tests whether newborns with neonatal abstinence syndrome (NAS) who receive a high-calorie formula for two weeks gain weight better than those on standard formula. The babies are managed using the Eat, Sleep, Console approach. The main goal is to see how much weight the…

This small pilot study tested whether giving spironolactone, a drug normally used for heart conditions, could help people with HIV reduce their alcohol use. Twenty-one participants received the drug along with support from a pharmacist and psychiatrist. The study focused on wheth…

This early-phase study tested an experimental drug called APX005M added to two standard immunotherapies (nivolumab and ipilimumab) in 26 people with advanced melanoma or kidney cancer who had not received prior immune therapy. The main goals were to check safety and find the best…

This Phase 3 trial tested whether taking Elagolix (a hormone-blocking pill) for two months before IVF could improve live birth rates in women with endometriosis. 103 women participated, and the main goal was to see if more babies were born after this pre-treatment. The study comp…

This study tested whether quitting cigarettes and e-cigarettes at the same time or one after the other is more effective. Nineteen adults who smoked and vaped received varenicline (a medication to reduce cravings) and counseling. Researchers measured abstinence and health markers…

This study tested two different approaches to help people recently released from jail or prison get connected to care for HIV, hepatitis C, STIs, and opioid use disorder. Over 600 adults took part. The goal was to see which method worked better for starting and staying on treatme…

This study tested whether community health workers (trained members of the community) can help people with type 2 diabetes and food insecurity use a program that provides free fruits and vegetables. 104 Hispanic adults on Medicaid in Connecticut took part. The goal was to see if …

This phase 2 trial tested the drug Taltz (ixekizumab) in 10 people with idiopathic subglottic stenosis, a rare condition where scar tissue narrows the airway. The goal was to see if blocking IL-17A could slow scar formation and lengthen the time between needed surgeries. Particip…

This study tested the Bright Bodies program, a family-based lifestyle intervention for children ages 7-13 with obesity. The program includes nutrition education, behavior modification, and exercise sessions. Researchers measured changes in BMI and other health outcomes across thr…

This study tested a program called the Transitions Clinic Network (TCN) for people leaving jail with opioid addiction. The program combines primary care, medication options, and a community health worker to address social needs. Researchers compared this to standard care and foll…

This study tested a computer-based tool that helps doctors follow guidelines for managing overweight and obesity in children. The tool was used in primary care clinics across three health systems, involving over 58,000 patients. Researchers measured changes in children's BMI and …

This study tested a program that gave low-income pregnant Latina women money each month to buy fruits and vegetables, along with nutrition education and text reminders. Over 10 months, the goal was to see if women bought and ate more produce and felt less food insecurity. The pro…

This study tested a combination of chemotherapy drugs given both before and after surgery for people with early-stage pancreatic cancer. The goal was to shrink the tumor before surgery and kill any remaining cancer cells afterward. 46 participants were enrolled to see if this app…

This study tested two online versions of parent management training for children diagnosed with conduct disorder or oppositional defiant disorder. Researchers wanted to see if online delivery could help families who cannot access in-person therapy. The study involved 86 children …

This study tested a GLP-1 drug (a type of medication that affects appetite) against a placebo in 96 adults with obesity. The goal was to see if the drug could reduce cravings, hunger, stress, and food intake. Results suggest the drug may help control eating behaviors and support …

This phase 2 trial tested a combination of two targeted drugs, afatinib and cetuximab, in 50 patients with advanced head and neck cancer that had spread or come back. All participants had already tried standard treatments like chemotherapy or immunotherapy. The main goal was to s…

This study tested whether a combination of naltrexone and bupropion can reduce binge-eating episodes and promote weight loss in people with binge-eating disorder and obesity. Participants took either the drug combo or a placebo for 12 weeks. The trial was very small, with only 3 …

This study tested different ways to help people living with HIV quit smoking. Participants received nicotine replacement therapy (like patches or gum), the medications varenicline or bupropion, and financial rewards for staying smoke-free. The goal was to see if these approaches …

This study tested whether the drug lisdexamfetamine (LDX) can help adults with binge-eating disorder and obesity avoid relapse. 61 participants who initially responded to treatment were randomly assigned to receive LDX or a placebo for 12 weeks. The main goal was to see if LDX re…

This pilot study tested a telehealth platform designed to encourage people with opioid use disorder to start and stay on medication treatment. 33 participants with a history of opioid overdose used the platform, which included chat-based support. The study measured whether they a…

This study tested a portable, low-field MRI machine to see if it can measure white matter hyperintensities (WMH) in the brain—a sign of small vessel disease. Researchers compared the portable MRI to the standard high-field 3T MRI in 100 adults with at least one vascular risk fact…

Researchers at Yale University developed a virtual reality game called Invite Only VR to help middle school students learn about the risks of vaping nicotine and cannabis. In the game, players practice refusing offers to vape in realistic social situations. The study tested the g…

This study explores whether virtual reality goggles and noise-cancelling headphones can make ketamine/esketamine treatment for depression more tolerable and effective. Participants receive a single treatment while immersed in a relaxing virtual environment. The goal is to see if …

This study tested whether a digital mindfulness app is practical and acceptable for people in early recovery from substance use disorders. 36 participants were randomly assigned to standard group therapy alone or standard therapy plus the app for 8 weeks. The main goal was to see…

This study tested a new pain self-management program called COPES against standard cognitive behavioral therapy for chronic pain in 764 veterans. The goal was to see if COPES could better reduce how much pain interferes with daily life. Participants had chronic musculoskeletal pa…

This study tests whether cognitive behavioral therapy (CBT) can reduce anxiety and depression in people with inflammatory bowel disease (Crohn's disease or ulcerative colitis). Participants receive either psychologist-led or self-administered CBT over 8 weeks. The goal is to see …

This study tested a new behavior therapy for teens with autism who struggle with irritability and aggression. The therapy teaches emotion regulation and coping skills for the challenges of growing up. 65 adolescents participated, and researchers measured changes in aggressive beh…

This study tested a phone-based counseling program called SBIRT-PM for veterans with chronic pain who were also at risk for substance misuse. Over 1,100 veterans participated, receiving up to four phone calls over 12 weeks to help them engage in non-drug pain treatments and reduc…

This study tested whether combining two medications, varenicline and guanfacine, helps people quit smoking better than standard treatments. 167 adult smokers who smoked at least 10 cigarettes daily took part. Researchers measured how long participants could delay their first ciga…

This study tested a web-based program that combines cognitive behavioral therapy and pain self-management for people being treated for opioid use disorder who also have chronic pain. The program includes online lessons and daily text surveys to track pain and activity. Researcher…

This study tested whether a 12-session parent-based treatment (Supportive Parenting for Anxious Childhood Emotions) can reduce anxiety in children by changing how their brains respond. 214 children with anxiety disorders participated. The goal was to see if parent training alone …

This study tested a behavioral therapy called BE-SMART-DR in 65 teens and young adults with bipolar disorder or major depression who had suicidal thoughts or past attempts. The therapy teaches self-directed strategies to regularize sleep and other daily rhythms to reduce short-te…

This study tested a short, self-guided online program designed to increase hope in women currently experiencing intimate partner violence. The program included facts about the brain, stories from other survivors, and writing exercises. Researchers enrolled 97 women to see if the …

This study tested whether a low-volume bowel prep (MoviPrep) works as well as a high-volume one (GoLYTELY) in hospitalized patients getting a colonoscopy. The goal was to see if the low-volume option is better tolerated while still cleaning the bowel adequately. 520 hospitalized …

This study tested whether a nerve block using bupivacaine (a numbing medicine) improves recovery after thyroid surgery. 160 adults were randomly assigned to receive either the nerve block or a placebo before surgery. The main goal was to see if the block led to a better quality o…

This study looked at whether a shorter (3-week) or longer (6-week) period of activity restriction after midurethral sling surgery leads to better recovery and satisfaction. 206 women who had the surgery were followed. The goal was to find the best balance between healing and gett…

This study tested whether stimulating a deep brain area (the central thalamus) could help people with temporal lobe epilepsy stay conscious during seizures. Five participants received implanted electrodes that delivered stimulation when a seizure was detected. The goal was not to…

This study tested a portable device that gently moves the hand to reduce muscle tightness (spasticity). Ten adults with hand paralysis or motor problems used the device for one 20-minute session. Researchers measured changes in muscle tone and asked participants about the device'…

This study tested a new device called Miraπ that physically moves a stroke patient's affected hand during mirror therapy. It compared this device to standard mirror therapy in 24 stroke patients with one-sided hand paralysis and pain. The goal was to see if the device could impro…

This study tested two online treatments for teenagers who have bulimia nervosa (binge eating and purging) and are overweight. The goal was to see if these therapies are practical and helpful for reducing binge eating and purging. Twenty-five teens participated, and the study meas…

This study tested whether giving women a single dose of olanzapine before outpatient surgery improves how they feel the day after. 384 women aged 18-50 took either the drug or a placebo. The goal was to see if it helps with nausea, pain, and overall recovery quality.

This study tested whether repeated doses of ketamine, given through an IV, can safely and effectively reduce depression in people with Parkinson's disease. 51 adults aged 40-80 with both conditions took part. Researchers compared ketamine to a placebo and used brain scans to expl…

This pilot study tested an online guided self-help program for teens aged 12–17 who binge eat and have a higher weight. Eight teens completed weekly online sessions over four months. The main goal was to see if the program was practical and acceptable, not to measure effectivenes…

This early-phase study tested whether cannabidiol (CBD) could safely help people with both opioid use disorder and chronic pain. Seven adults on methadone or buprenorphine received single doses of CBD (400, 800, or 1200 mg) or a placebo in a crossover design. Researchers measured…

This study tested a new web-based tool called LDART that provides daily social support to people who drink heavily and want to cut down. Each night, users set a goal for the next day and check in the following night to see if they met it, receiving encouraging messages from the r…

This study tested a mobile app that gives personalized encouragement and health insights based on blood sugar, exercise, mood, and sleep patterns. The goal was to help 24 middle-aged adults with type 1 diabetes or similar conditions exercise more often and confidently. The app ai…

This study tested whether a home-based digital brain training program could help with depression, thinking skills, and quality of life in 36 people with cancer or end-stage kidney disease. Participants used a computer program called Rejuvenate for 30 minutes, four times a week, f…

This study reviewed medical records of 320 children with biliary atresia, a rare liver disease, treated at hospitals in the northeastern U.S. between 2012 and 2021. The goal was to find which factors lead to better outcomes, such as avoiding liver transplant or clearing jaundice.…

This study tested how a menthol ban in cigarettes and e-cigarettes affects people who currently smoke menthol cigarettes. 151 adult smokers were asked to try different scenarios, like a ban on menthol cigarettes only or a total ban on menthol flavors. The goal was to see if they …

This study tested whether simple activities like singing, listening to music, or reading books with your baby can improve health outcomes for both infants and parents. Over 200 families with babies up to 4 months old were randomly assigned to one of four groups: interactive singi…

This study from Yale University looked at how menthol flavor in e-cigarettes affects smoking behavior and nicotine levels in people who smoke menthol cigarettes. Fourteen adult smokers participated in lab sessions where they used e-cigarettes with menthol or non-menthol flavor. R…

This completed study enrolled 311 people with myasthenia gravis, a condition that causes muscle weakness. Researchers collected clinical information and blood samples to build a repository for future studies. The goal is to help scientists better understand the disease and potent…

This study used PET scans to compare the density of synapses—connections between brain cells—in 40 people: experienced meditators and non-meditators. Researchers gave participants a radioactive tracer that binds to a protein on synapses, then scanned their brains. The goal was to…

This completed early-phase study at Yale University tested how different doses and delivery rates of IV nicotine affect its abuse potential and its ability to reduce smoking urges. Twenty daily smokers received low and high doses of nicotine at various speeds. The goal was to bet…

This study used brain scans to look at two things in people with depression or bipolar disorder: a glutamate receptor called mGluR5 and the density of connections between brain cells (synapses). Researchers compared 120 participants, including healthy volunteers, using PET and MR…

This study tested a computer tool designed to help emergency room doctors follow best practices for treating opioid use disorder. Researchers looked at whether the tool increased the use of standard assessments and buprenorphine treatment. The study involved 267 adults with moder…

This study tested whether a portable MRI scanner can start scans faster than a conventional MRI in emergency patients. 100 adults in the ER who needed a brain MRI were randomly assigned to get a portable scan plus standard care, or standard care alone. Researchers measured the ti…

This study aimed to understand what helps or hinders breast cancer screening using a simple physical exam in primary health centers in Abuja, Nigeria. Researchers interviewed and observed 62 healthcare workers and community members to identify barriers and develop practical strat…

This study looked at 165 emergency room patients with high blood pressure but no known heart problems. Doctors used a portable ultrasound to check for left ventricular hypertrophy (thickening of the heart muscle), a sign of long-term strain. They then gave some patients special d…

This study looked at how people with autoimmune diseases like multiple sclerosis or blistering skin conditions respond to COVID-19 vaccines while on B-cell depleting therapies. Researchers measured antibody levels and T-cell activity over time to understand vaccine effectiveness …

This study tested whether adding a chatbot interface makes doctors more likely to trust and use an AI tool that predicts risk in patients with upper stomach bleeding. 108 medical residents participated in simulated emergency scenarios, some using the AI alone and others using the…

This pilot study tested a digital program called the Be There Certificate, which teaches college students how to recognize signs of mental health struggles and how to offer support. 102 students living in dorms participated. The goal was to see if the program is easy to use and i…

This early-phase study looked at how a single dose of cannabidiol (CBD) affects brain inflammation and pain sensitivity in 28 healthy adults. Researchers used brain scans to measure inflammation and a skin cream test to check pain response. The goal was to understand CBD's potent…

This study looked at whether letting children start preschool at age 3, instead of the usual age 4, improves their learning and helps their mothers find work. Researchers worked with over 2,000 families in rural Kenya. They measured children's thinking and language skills, and tr…

This study tested whether a virtual reality program (DeepDream) can produce experiences similar to psychedelic drugs. Ten healthy volunteers took part at Yale University. Researchers measured changes in consciousness, mystical feelings, and sense of self. The goal was to see if V…

This study looked at how the heart failure drug Entresto (LCZ696) lowers blood pressure and helps the body get rid of salt. 46 stable heart failure patients took part. Researchers measured blood pressure and urine sodium levels to understand the drug's effects.

This pilot study tested a suicide prevention package (SuPP) for women in rural Pakistan who are at risk. The package includes a safety plan and follow-up visits from trained peers. Researchers wanted to see if it was feasible and acceptable to use within existing mental health pr…

This pilot study tested whether a patient navigator—a person who helps coordinate medical care—could increase eye exam rates in 35 adults with diabetes who were at high risk for blindness. Participants met with a navigator quarterly to overcome barriers to care. The study measure…

This study looked at how a single dose of THC (the active ingredient in cannabis) changes immune-related genes and proteins in the blood. Researchers compared 56 adults with and without HIV to see if the effects differ. The goal was to understand THC's impact on the immune system…

This study tested a special imaging method (SPECT/CT) to measure blood flow in the leg muscles of people with peripheral arterial disease (PAD) and diabetes. Researchers compared these images to those from healthy volunteers to see how treatment affects muscle blood flow. The goa…

This completed pilot study tested how different amounts of a coolant called WS-3 affect the sensation of e-cigarettes in 31 adult users. Participants tried various levels of WS-3 and rated the coolness, sweetness, and harshness. The goal was to find the right concentrations for f…

This completed study at Yale University enrolled 600 men with prostate cancer to test a new biopsy method that combines MRI and ultrasound images. The goal was to collect extra tissue samples for detailed single-cell analysis, looking at proteins and other markers to better predi…

This study looked at ways to prevent tuberculosis (TB) in Malaysian prisoners, many of whom also had HIV, opioid addiction, or hepatitis. Researchers compared a standard 40-week TB prevention treatment with a shorter 12-week option. The goal was to see which approach worked bette…

This study tested whether a computer tool that gives real-time feedback can help community health workers in Nigeria improve their patient care decisions. Over 490 patients were seen by a health worker who used the tool, then by a fully trained doctor. Researchers compared the he…

This completed study at Yale University looked at how 66 adult smokers (ages 21-44) perceive sweet, cooling, and unflavored e-cigarette liquids. Participants tried each flavor and rated its appeal, sensory effects, and how much they wanted it compared to money. The goal was to se…

This completed study tested different strategies to help emergency doctors start buprenorphine treatment for people with opioid use disorder. Researchers used a computer system to prompt nurses and doctors, and gave patients educational materials. The goal was to see which combin…

This study used MRI and PET scans to examine the glutamate system in people with major depression, PTSD, or bipolar disorder. Researchers aimed to understand how a specific glutamate receptor (mGluR5) relates to these conditions. 180 participants aged 18-70 completed cognitive te…

This study looked at how flavors in e-cigarettes affect how much adult smokers like and want them. It included 130 smokers aged 21-50 who used only e-cigarettes for two weeks. The goal was to measure their reactions, not to treat or cure any condition.

This completed study worked with healthcare workers, officials, and community members in Soweto, South Africa, to figure out the best ways to offer breast cancer screening using simple clinical breast exams in local clinics. Researchers observed clinic workflows and held group di…

This study looked at how the strength and form of nicotine in e-cigarettes affect how fast and how much nicotine gets into the blood. Thirty-six adults who vape regularly took puffs from different e-cigarette setups while their blood was sampled through a small tube in their arm.…

This completed Phase 1 study at Yale University looked at how vitamin D (calcitriol) affects dopamine receptors in the brains of people with opioid use disorder. Five participants received either vitamin D or a placebo and had PET scans to measure brain activity. The goal was to …

This study tested whether a bacterial toxin called endotoxin can increase alcohol consumption in people with alcohol use disorder. 27 participants received either endotoxin or a placebo, and their alcohol intake was measured during a 2-hour session. The goal was to gather early d…

This study looked at whether telling older women about overdiagnosis (finding cancers that would never cause harm) changes their desire to get mammograms. Over 300 women aged 70 and older watched a video explaining overdiagnosis and answered surveys about their screening intentio…

This study looked at how cannabis use affects brain receptors and electrical activity, and how these change when people stop using. Researchers used brain scans and EEGs in 162 people, including cannabis users and healthy controls. The goal was to understand the brain's recovery …

This study from Yale University looked at what happens when teenagers with type 1 diabetes follow a very low carbohydrate diet for two weeks. Nineteen participants ate either a low-carb or standard diet to see how it affected their blood sugar levels and brain function. The goal …

This completed Phase 2 trial tested whether a drug called CVL-562 can change brain activity related to working memory in people with early schizophrenia. 112 participants received different doses or a placebo while undergoing brain scans. The goal was to find brain imaging marker…

This study looked at how a short stressful experience changes the way the brain learns and remembers. Healthy adults aged 18-45 underwent a cold water stress test or a control version while their brain activity was measured with fMRI. The goal was to understand the neural mechani…

This study tested a new way to find people exposed to tuberculosis (TB) in Cali, Colombia. Instead of relying only on in-person visits, researchers used a mobile phone chatbot and a simple oral (mouth) test that people could do at home. The goal was to see if this approach was pr…

This study looked at how gut bacteria might influence metabolism in 38 teenagers, some with obesity and some lean. Participants ate special diets while researchers measured short-chain fatty acids and fat production in the liver. The goal was to understand if gut bacteria play a …

This study, completed by Yale University, tested whether a standardized field test can measure marijuana impairment in drivers. 41 participants who use marijuana regularly completed cognitive tasks and simulated driving after smoking either medium-THC or placebo marijuana. The go…

This study looked at whether a blood test called DiviTum-TKa can help doctors check if patients with metastatic breast cancer are taking their CDK4/6 inhibitor medication correctly and if other drugs are interfering. The test measures a marker of cell growth to see if the treatme…

This study tested a new way to send alerts to doctors when a patient develops acute kidney injury (AKI). Instead of alerting for every case, the system used a model to identify which patients would benefit most from the alert. Over 2,000 adults with AKI in the hospital were inclu…

This completed study from Yale University enrolled 565 children aged 6-11, both with and without autism, to confirm whether certain brain wave and eye-tracking measures can serve as reliable biomarkers. The goal is to provide objective tools for future clinical trials to measure …

This early-phase study tested whether giving chloride supplements (lysine chloride) to people with stable heart failure could affect their body's fluid balance. Twenty participants took either the supplement or a placebo three times daily for five days. The goal was to understand…

This study tested whether a special MRI contrast agent called ferumoxytol can detect inflammation in brain arteries of people who recently had a stroke. Researchers compared it to standard gadolinium contrast in 30 participants with narrowed brain arteries. The goal was to see if…