Chloride pills tested for heart failure fluid control
NCT ID NCT03440970
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This early-phase study tested whether giving chloride supplements (lysine chloride) to people with stable heart failure could affect their body's fluid balance. Twenty participants took either the supplement or a placebo three times daily for five days. The goal was to understand how chloride affects blood volume and kidney function, not to treat symptoms directly.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Lysine Chloride
What this could lead to
If successful, this could point toward a new way to manage fluid balance in heart failure patients.
What could go wrong
This is a very small, early-phase study with only 20 participants. It is designed to gather basic information, not to prove a treatment works.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Yale University
New Haven, Connecticut, 06510, United States