Yale University

This study is testing whether a telehealth platform called RecoveryPad can help adults with moderate to severe opioid addiction. Researchers want to see if using this digital tool helps people get medication treatment faster and reduces overdose events. The study will enroll 470 …

This study is testing whether a mobile pharmacy clinic can effectively provide a monthly injection for opioid addiction. The injection, called BRIXADI, is a long-acting form of buprenorphine. Researchers will enroll 60 people to see if this mobile delivery method is practical and…

This study aims to see if a special therapy program helps women with opioid addiction and a history of partner violence stay in their medication treatment longer. It compares a new stepped-care approach, which offers different levels of therapy based on need, to standard treatmen…

This study aims to develop and test a culturally adapted version of a reward program called Contingency Management to help Black adults with stimulant use disorder. The program uses positive reinforcements, like rewards, to encourage drug-free behaviors. Researchers will pilot th…

This small Yale University study will test if the medication semaglutide (a drug used for weight loss and diabetes) is practical and acceptable for treating alcohol use disorder in adults who have had weight loss surgery. The researchers want to see if the drug might help reduce …

This study aims to improve a brief motivational conversation to help young adults (ages 18-25) who were injured in an assault and also use alcohol or cannabis. Researchers will test if this adapted conversation, delivered in the emergency room, is practical and acceptable to part…

This study aims to determine which of two existing immune-modulating drugs—anakinra or tocilizumab—works better for treating NORSE, a rare and devastating condition where previously healthy people develop continuous seizures that don't respond to standard treatments. The trial wi…

This study is testing a new digital program called LDART to see if it's practical and helpful for adults struggling with stimulant addiction. The program involves 28 nights of online activities. Researchers will measure if people can stick with the program and if it helps them re…

This study aims to see if a sleep medication (eszopiclone) can help people with sleep apnea use their CPAP machine more consistently and improve their thinking skills. Researchers will enroll 250 adults newly diagnosed with sleep apnea. They will test if the medication, by helpin…

This study is testing a new immune-boosting drug called CUE-101, both alone and combined with the immunotherapy drug pembrolizumab, for people newly diagnosed with advanced head and neck cancer caused by HPV-16. The goal is to see if these treatments given before standard care ar…

This study is testing if apremilast, a medication already used for psoriasis, can help people with alcohol use disorder drink less. Researchers will give 120 adults either a 60mg or 90mg daily dose of the drug or a placebo pill and measure their alcohol consumption in lab session…

This study is testing whether adding a special high-pressure oxygen treatment to a hip surgery helps patients with a condition where the hip bone is dying from poor blood flow. The goal is to see if this combination better controls pain and slows down the disease to prevent the h…

This study tests if paramedics can safely start a medication called buprenorphine for people with opioid addiction during emergency calls. Researchers want to see if this early help makes it easier for people to get into longer-term treatment. The study will first check if the pa…

This is a small pilot study to see if a digital program called 'Let's Do Addiction Recovery Together!' (LDART) is practical, acceptable, and shows early signs of helping adults with alcohol use disorder. The study will enroll 80 adults in Connecticut who report heavy drinking and…

This study is testing if placing a birth control implant in a new spot on the shoulder blade works as well as the usual location. Researchers will follow 62 healthy women for at least two years to measure the drug levels in their blood and track any side effects. The goal is to s…

This small Yale study is testing whether nimodipine, a blood pressure medication, can reduce alcohol drinking in people with alcohol use disorder. Five non-treatment-seeking adults will stay overnight in a hospital, receive the drug, and then participate in a lab session where th…

This study is testing an experimental drug called sacituzumab tirumotecan for people with a hard-to-treat type of breast cancer that has spread to the brain. The trial will enroll 20 participants to see if the drug can shrink or control the brain tumors and improve survival. The …

This study tests whether a computer alert system helps doctors prescribe recommended medications for chronic kidney disease patients. When doctors open a patient's chart, the system checks if the patient qualifies for certain kidney-protecting drugs and shows the doctor which med…

This study is testing a program designed to help people who smoke and are planning weight-loss surgery. The program combines two medications with behavior therapy to help participants quit smoking and lose weight before their operation. Researchers will compare this combined appr…

This study is testing whether a free smartphone app called Thrive AI Health can help adults with type 2 diabetes or who are overweight improve their daily habits. For 12 weeks, one group will use the AI-powered app, which gives personalized advice on diet, exercise, stress, and s…

This study is testing a new handheld ultrasound device called the Accuro 3S. Researchers want to see if it helps doctors place spinal or epidural needles more accurately on the first try, with fewer needle movements. They'll test it on 50 patients who need these procedures for su…

This study is testing whether artificial intelligence (AI) can help doctors find a rare heart condition called ATTR amyloidosis earlier. It will check if AI can spot signs of the disease in standard heart tests (ECGs and echocardiograms) from 150 adults with heart failure. The go…

This study is testing a new AI tool called FibroX to see if it helps primary care doctors more accurately diagnose advanced liver scarring in patients with fatty liver disease. Doctors will review simulated patient cases, using either their usual methods or the AI tool, to see wh…

This study is testing whether an automated AI chatbot can encourage men to get tested for HIV. 80 men in Malaysia will be randomly assigned to either use the chatbot or receive standard educational materials. The chatbot sends personalized messages with information and motivation…

This study aims to adapt an existing, proven HIV and substance use prevention program to better fit the needs of Black teenage girls in Paterson, New Jersey. Researchers will work directly with a small group of girls (ages 13-18) and community advisors to tailor the program's con…

This study is testing a virtual reality (VR) program delivered in middle school classrooms to prevent teenagers from starting to use e-cigarettes. About 1,250 eighth-grade students in Connecticut and Massachusetts will either use the VR game or receive standard health education. …

This study is testing a virtual health education program called LEARN 2. It aims to prevent heart and metabolic diseases in men living with HIV by teaching them about shared risk factors. Researchers will compare men using the weekly online program to a waitlist group to see if i…

This study aims to find the best way to help people get screened for colorectal cancer. Researchers will test different text messages and clinic reminders sent to 2,000 patients who are overdue for their screening. The goal is to see which approach gets more people to schedule or…

This study is testing two support programs to help Black men who have sex with men take their HIV prevention medication (PrEP) more consistently. Researchers will compare a care coordination program alone versus that program combined with group counseling sessions. The study will…

This study tests a counseling program called Healthy Families-PrEP that helps women in rural Uganda use HIV prevention medication (PrEP) when they are trying to get pregnant, during pregnancy, and after giving birth. The goal is to reduce HIV infections in women and prevent passi…

This study is testing if a drug called adalimumab can slow or stop the brain changes that lead to Parkinson's disease in people with REM Sleep Behavior Disorder (RBD). About 108 people with RBD will receive either the drug or a placebo for 96 weeks. Researchers will use brain sca…

This study is testing a chatbot designed to help increase awareness and use of HIV prevention medication (PrEP) among Black men who have sex with men in the Southern United States. The region has the highest rates of new HIV infections in the country, but use of prevention tools …

This study is testing a nutrition education program designed with local communities in northern Ghana. It aims to help first-time pregnant women eat a more varied and nutritious diet to support healthy weight gain. Researchers want to see if this improves the mothers' health know…

This Yale University study is testing whether a single dose of psilocybin (the active compound in 'magic mushrooms') can help people with chronic low back pain get more benefit from physical therapy. Researchers want to see if the drug helps patients become more aware of their bo…

This study aims to see if a self-guided mobile app can help people with a history of cancer manage emotional distress. Researchers will ask 50 participants to use the app for 8 weeks and track their mood, coping skills, and quality of life. The main goal is to find out if people …

This study is testing if a single session of moderate cycling can help reduce the immediate distress and urges caused by obsessive-compulsive disorder (OCD) and improve mental flexibility. Researchers at Yale will compare 20 minutes of moderate cycling to light cycling in 50 adul…

This study is testing a new computer tool for doctors. The tool is designed to help identify hospitalized heart failure patients who might benefit from palliative care—a type of medical care focused on relieving symptoms and stress. The goal is to see if this tool makes it easier…

This study aims to see if a new automated ultrasound device helps doctors place labor epidurals more easily than a standard handheld one. It will involve 200 women in labor and measure how many needle adjustments are needed and how accurate the device's guidance is. The goal is t…

This Yale University study is exploring whether listening to music can help reduce abdominal pain in people with Irritable Bowel Syndrome (IBS). Researchers will enroll 30 adults with IBS to follow a 4-week music listening program at home while wearing special sensors. The main g…

This study is testing whether a daily fiber supplement called inulin can reduce knee pain and inflammation in older adults with osteoarthritis. For 8 weeks, 84 participants will take either inulin or a placebo powder to see if it improves gut health and lowers a blood marker link…

This study is testing if a new technique using a patient's own skin cells (RECELL®) can lead to a better skin color match after reconstructive surgery for head and neck cancer. Researchers will compare the new method to two standard skin grafting techniques in 20 patients. The ma…

This study is testing a portable hand rehabilitation device for people who have had a stroke. It will compare the device to standard hand therapy to see if it helps improve movement, dexterity, and pain. The trial will enroll 12 participants who are within two months of their str…

This study is creating and testing a text message program to support family caregivers after their loved one with dementia is discharged from the emergency room. The goal is to see if regular, supportive texts can help caregivers feel more prepared and less burdened during the tr…

This study aims to find the best way to help pediatric clinics offer more confidential HIV testing to their teenage patients. It will test two main ideas: training doctors on state laws and setting up new clinic protocols. The goal is to see if these changes make it easier and mo…

This study aims to understand if men and women find menthol e-cigarettes appealing or addictive in different ways. Researchers will ask 60 current smokers who have tried e-cigarettes to try menthol vapes with and without nicotine and measure their preferences. The goal is to gath…

This study aims to better understand the brain biology of post-traumatic stress disorder (PTSD) and alcohol use disorder. Researchers will use special brain scans to measure a specific protein in the brains of 160 people with these conditions and healthy volunteers. The goal is t…

This small, early-stage study aims to understand if taking very small, non-psychedelic doses of psilocybin (from 'magic mushrooms') for 30 days can change mood, thinking skills, or brain activity. Researchers will compare 20 healthy adults who have never used psychedelics, giving…

This study is testing whether a new personal health library app is helpful for people who have recently been released from jail or prison. Researchers will enroll 100 adults with a chronic health condition to see if they will use the app to organize their medical information and …

This Yale University study aims to understand how the brain learns and remembers new speech movements. Researchers will use brain scans (fMRI) and a non-invasive stimulation technique (TMS) on 50 healthy participants to see which brain areas are involved. The goal is to build a b…

This study aims to develop and test a new way to provide mental health support to adults who are going back to school to earn their high school diploma. Researchers from Yale University will work with 340 adult students and staff to see if a specific screening and counseling prog…

This Yale University study aims to understand how two people's brains work together during live, face-to-face social interactions. Researchers will use brain imaging and mild, non-invasive brain stimulation on 50 healthy adults to measure changes in brain activity and eye contact…

This study is testing whether an artificial intelligence (AI) tool can predict how quickly a common heart valve condition called aortic stenosis might worsen in older adults. Researchers will enroll 210 people aged 65+ who already have early signs of the condition. The study will…