Yale University

This study tests whether adding hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) to a standard hip procedure (core decompression with bone marrow cells) can reduce pain in people with early-stage avascular necrosis of the hip. The trial will enroll 400 p…

This study will test a culturally adapted version of contingency management, a program that gives rewards for staying drug-free, in 70 Black adults with stimulant use disorder. Participants will provide urine samples twice weekly for 12 weeks and receive escalating rewards for ne…

This phase 3 trial tests whether radiation therapy can prevent Dupuytren's contracture—a condition where fingers bend toward the palm—from progressing or coming back after treatment. About 158 adults will receive radiation to the hand, and researchers will measure changes in fing…

This study tests a refined computer alert that prompts emergency room doctors to order a consultation with an addiction counselor for patients with opioid use disorder. Researchers will enroll 300 adults with moderate to severe opioid use disorder who visit the ER. The goal is to…

This study tests whether a comprehensive telehealth platform called RecoveryPad helps adults with moderate to severe opioid use disorder start and stay in medication treatment. Researchers will enroll 470 participants and track attendance at treatment appointments within 30 and 9…

This study looks at whether eating six olives every day for five weeks can improve cholesterol and other health markers in healthy young adults. Researchers will compare blood tests from 226 Yale college students before and after the olive-eating period. The goal is to see if thi…

This Phase 3 trial tests two existing anti-inflammatory drugs, anakinra and tocilizumab, in 438 patients with NORSE, a rare condition causing continuous seizures that don't respond to standard treatments. Patients are randomly assigned to one drug within 7 days of illness, and re…

This study tests a digital pill system that tracks when people with alcohol-related liver disease take their medication (acamprosate) and provides personalized support to help them stay on track. The system includes a sensor in the pill, a wearable patch, and a smartphone app wit…

This pilot study will test whether giving a monthly extended-release buprenorphine injection (BRIXADI) from a mobile pharmacy clinic is acceptable and practical for people with opioid use disorder. About 60 participants will receive the shot for 6 months, and researchers will tra…

This study tests a program that combines medication (Naltrexone + Bupropion) with behavior therapy to help adults lose weight and quit smoking before bariatric surgery. Researchers will compare this approach to standard care in 64 participants aged 18-65 who smoke and have obesit…

This study tests a drug called sacituzumab tirumotecan in 20 people with triple-negative breast cancer that has spread to the brain. The drug is given through a vein twice a month. The main goal is to see if it can shrink brain tumors. This is an early-phase trial, so it focuses …

This study will test if artificial intelligence (AI) can spot a rare heart condition called ATTR-CM in people with heart failure. Researchers will use AI to analyze electrocardiograms (ECGs) and echocardiograms (Echo) from 150 adults. The AI's findings will be checked against a s…

This pilot study tests whether an AI tool called FibroX can help primary care providers better diagnose advanced liver fibrosis in people with MASLD, a common liver condition. Forty providers will review simulated patient cases, using either standard methods or FibroX, which give…

This study tests whether adalimumab, an anti-inflammatory drug, can prevent brain changes linked to Parkinson's disease in 108 people with REM sleep behavior disorder (RBD). RBD often precedes Parkinson's. Participants will receive adalimumab or a placebo every two weeks for two …

This study tests a virtual platform called LEARN 2 that provides tailored education to help men living with HIV prevent related health problems like heart disease and metabolic issues. Participants will use the platform weekly, attend live health educator sessions, and track thei…

This study will test two behavioral programs designed to help Black men who have sex with men (MSM) take PrEP regularly to prevent HIV. The C4 program offers personalized support to overcome barriers like stigma and healthcare access. The C4+3MV program adds group sessions to enc…

This study tests different methods to help people get screened for colorectal cancer. About 2000 adults from community health clinics will receive reminders or extra support to schedule a colonoscopy or stool test. The goal is to see which approach works best to increase screenin…

This study tests a counseling program called Healthy Families PrEP for HIV-negative women in rural Uganda who are planning pregnancy or recently gave birth. The program provides information and support to help women take daily PrEP pills to prevent HIV. Researchers will enroll 66…

This study tests a virtual reality (VR) program for 8th graders to prevent them from starting to use e-cigarettes. About 1,250 students from schools in Connecticut and Massachusetts will play a VR game that teaches skills to handle emotions and resist vaping. The goal is to see i…

This study will test a chatbot designed to increase awareness and use of PrEP, a daily pill that prevents HIV, among Black men who have sex with men (MSM) in the Southern United States. About 145 participants will interact with the chatbot over 90 days, answering questions and re…

This study will adapt two proven prevention programs (SISTA/SIHLE) to help Black adolescent girls in Paterson, New Jersey avoid HIV/AIDS and substance abuse. Researchers will use focus groups with 10 girls aged 13-18 to understand their needs and then measure changes in drug use,…

This phase 2 trial tests whether a single dose of psilocybin, the active ingredient in magic mushrooms, can improve depression in people with Parkinson's disease. Forty participants will receive a low to high dose with psychological support. The study measures changes in depressi…

This study will follow 80 people with chronic pain (like back, hip, or nerve pain) who are getting a procedure called cryoneurolysis, which uses cold to temporarily block pain signals. Researchers want to see if it leads to meaningful pain relief and better daily function over 12…

This early-phase study at Yale will test whether a single 25mg dose of psilocybin is safe and well-tolerated in 10 veterans who smoke daily and have chronic pain. Researchers will monitor side effects and explore whether the drug can improve pain and boost motivation to quit smok…

This study looks at whether emergency medical services (EMS) can safely start buprenorphine treatment for people with opioid use disorder right at the scene of an emergency. Researchers will first test how practical and acceptable this approach is, then track whether patients sta…

This study tests whether adding peer support specialists to emergency department teams can reduce the use of physical and chemical restraints for agitated patients. Researchers will compare restraint rates before and after the peer support program is introduced across several hos…

This early study will test whether nimodipine, a drug usually used for blood pressure, can reduce alcohol drinking and cravings in heavy drinkers. Five adults with Alcohol Use Disorder will stay overnight at a hospital, take nimodipine, and then have the option to drink alcohol o…

This study tests a new text messaging program called CAPTURE for caregivers of people with dementia after an emergency department visit. The program sends up to two tailored texts per day for 30 days, covering topics like symptom monitoring, caregiver well-being, and community re…

This pilot study from Yale University will test whether listening to calming, instrumental music can reduce pain and stress in people with irritable bowel syndrome (IBS). Thirty adults with moderate IBS pain will listen to pre-recorded playlists for 20 minutes twice a day, five d…

This study tests whether a single dose of psilocybin can help people with chronic low back pain become more aware of their body, which may lead to better pain relief and improved results from physical therapy. About 45 adults aged 18-65 with long-lasting back pain will receive ps…

This study from Yale University will test whether 20 minutes of moderate cycling can reduce obsessive thoughts, compulsive urges, and improve thinking flexibility in adults with OCD. Fifty participants will be randomly assigned to either moderate or low-intensity cycling. Researc…

This study tests whether inulin, a prebiotic fiber from chicory root, can reduce inflammation and knee pain in older adults with osteoarthritis. Over 8 weeks, 84 participants will take either inulin or a placebo daily. Researchers will measure changes in blood markers of inflamma…

This study tests whether an automated ultrasound device helps doctors place labor epidurals with fewer needle sticks compared to a traditional ultrasound. Two hundred women receiving epidurals for labor pain will be randomly assigned to one of the two devices. The main goal is to…

This pilot study from Yale University will test whether very low, non-hallucinogenic doses of psilocybin (the active compound in magic mushrooms) can improve mood, thinking, and quality of life. Twenty healthy adults with no prior psychedelic use will take either psilocybin or a …

This study aims to improve a short motivational conversation to help young adults (ages 18-25) who were injured in an assault and also misuse alcohol or cannabis. Researchers will interview and survey 50 participants from a hospital violence intervention program to understand how…

This study tests whether a team-based care strategy for bubble continuous positive airway pressure (bCPAP) is feasible for children with severe pneumonia in Pakistan. Researchers will enroll 95 children and their caregivers to see if a larger trial is possible. The focus is on wh…

This study tests whether a pop-up alert in electronic medical records helps doctors prescribe more recommended medications for chronic kidney disease (CKD). About 1,000 patients with CKD will be included, and their doctors will either see the alert or not. The goal is to see if t…

This study tests two new types of nicotine labels for e-cigarettes: one showing nicotine concentration and another showing nicotine emissions (flux). Researchers will survey 2500 youth and adults in the US to see if these labels help people better understand nicotine strength com…

This study looks at how men and women differ in their attraction to and addiction risk from menthol-flavored e-cigarettes, both with and without nicotine. Researchers will measure choices and effort to get the product in 60 adult smokers who already use e-cigarettes. The goal is …

This early study tests a new radioactive tracer called 18F-TPP to see if it can map the energy levels inside cells using PET scans. Researchers will study 24 healthy adults to understand how the tracer moves through the body and develop methods to measure cell membrane potential.…

This study will test whether a new smartphone app helps people recently released from prison manage their health information. Researchers will enroll 100 adults with at least one chronic condition who have been out of jail for less than a year. The goal is to see if the app is ea…

This study tests a clinical decision support tool that helps doctors decide when to refer heart failure patients to palliative care. The tool uses a risk model to predict one-year survival and provides guidance at the point of care. Researchers will enroll 2,260 participants, inc…

This study tests a mobile health program called SAMU to help adults in Uganda who have HIV, high blood pressure, and mental health issues like depression or anxiety. About 1,500 participants will use their phones for mental health screening and get connected to care. The goal is …

This pilot study will test a series of brief, private text messages sent via WhatsApp or Telegram to help people who use drugs in Kazakhstan feel more comfortable seeking PrEP, an HIV prevention pill. The messages address stigma, confidentiality worries, and misinformation. Forty…

This study tests whether real-time fMRI neurofeedback can help people with brain tumors (gliomas) shift language activity away from the tumor area before surgery. Only 4 participants will be enrolled to see if the approach is feasible, safe, and acceptable. It is a very early, sm…

This study will test a new ultrasound device called Accuro 3S that provides live guidance during epidural or spinal needle placement. Researchers want to see if it reduces the number of needle attempts and improves accuracy compared to standard methods. The trial will enroll 50 p…

This study will test whether an artificial intelligence chatbot can encourage men who have sex with men in Kuala Lumpur, Malaysia to get tested for HIV. 80 participants will be randomly assigned to receive either automated chatbot messages with HIV testing information or standard…

This study looks at whether making it easier for teens to have private, confidential talks with their doctor can increase HIV testing. Researchers will work with 4 pediatric clinics to see if this approach is practical and well-liked by staff. The goal is to learn how to make HIV…