Microdosing magic mushrooms: brain boost or placebo?
NCT ID NCT07449351
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This pilot study from Yale University will test whether very low, non-hallucinogenic doses of psilocybin (the active compound in magic mushrooms) can improve mood, thinking, and quality of life. Twenty healthy adults with no prior psychedelic use will take either psilocybin or a placebo three times a week for 30 days. Researchers will measure changes in memory, attention, emotional well-being, and brain activity using MRI scans.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- psilocybin (very low dose, 2.0 mg)
- What this could lead to
- If it works, this could point toward a safe, non-hallucinogenic way to boost mood and mental sharpness in daily life.
- What could go wrong
- This is a very early, small pilot study with only 20 people. It may not show clear benefits, and results may not apply to the general public.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Olin Neuropsychiatry Research Center
Hartford, Connecticut, 06106, United States