The 'Love Hormone' as a painkiller? a trial tests oxytocin after brain surgery
NCT ID NCT07730294
First seen Jul 28, 2026 · Last updated Jul 29, 2026 · Updated 1 time
Summary
This study tests whether taking oxytocin as a nasal spray before and after pituitary surgery can reduce pain and improve emotional well-being. Researchers want to know if oxytocin changes how the brain links emotions, social experiences, and pain. Adults aged 30 to 75 who need pituitary surgery may join.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- intranasal oxytocin (TNX-1900) at low or high dose
- What this could lead to
- If it works, this could point toward a new, non-opioid way to manage post-surgical pain by targeting the brain's social and emotional pathways.
- What could go wrong
- This is a small Phase 2 trial, so results may not apply broadly. Oxytocin's effects on pain are still uncertain, and side effects from nasal sprays can occur.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Yale University
New Haven, Connecticut, 06510, United States
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