Magic mushroom compound shows promise for tough depression
NCT ID NCT03554174
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This small pilot study tests whether psilocybin, the active ingredient in magic mushrooms, can change brain connections to improve depression. 18 adults with major depression who didn't get better with standard treatments will receive psilocybin. Researchers will measure brain activity and memory to see if the drug helps rewire the brain and ease symptoms.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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VA Connecticut Healthcare System, West Haven Campus
West Haven, Connecticut, 06516, United States
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