Could less radiation be safer for tough lung tumors?

NCT ID NCT04210492

Recruiting now Disease control Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a lower-dose radiation regimen for people with non-small cell lung cancer located near the center of the chest. The goal is to see if giving a total of 45 Gray in three sessions can control the tumor while reducing damage to nearby organs like the heart and major airways. The trial involves about 36 participants and tracks side effects and cancer control over two years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: radiation therapy (45 Gray in 3 fractions)
What this could lead to: If successful, this approach could offer a safer radiation option for hard-to-treat central lung tumors, with fewer side effects and similar cancer control.
What could go wrong: This is an early-phase trial with only 36 participants, so results may not apply broadly. Lower radiation might be less effective at controlling tumors, and there are still risks of damage to nearby organs.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER

Contacts and locations

Locations

Smilow Cancer Hospital
RECRUITING

New Haven, Connecticut, 06511, United States
Smilow Cancer Hospital - Hamden Care Center
RECRUITING

Hamden, Connecticut, 06518, United States
Smilow Cancer Hospital Care Center - Guilford
RECRUITING

Guilford, Connecticut, 06437, United States
Smilow Cancer Hospital Care Center - Trumbull
RECRUITING

Trumbull, Connecticut, 06611, United States
Smilow Cancer Hospital Care Center - Waterford
RECRUITING

Waterford, Connecticut, 06385, United States
Smilow Cancer Hospital Care Center at Greenwich
RECRUITING

Greenwich, Connecticut, 06830, United States

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