New study probes brain chemistry to understand alcoholism risk

NCT ID NCT05203965

Recruiting now Knowledge-focused Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Oct 31, 2025 · Last updated May 24, 2026 · Updated 27 times

Summary

This study aims to understand why some people are more vulnerable to alcoholism by looking at brain activity. Researchers will give 80 adults either a single dose of the drug mavoglurant or a placebo, then use MRI scans to see how their brains respond to rewards and alcohol-related images. The goal is to learn more about the brain chemistry behind addiction risk, not to test a treatment.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Hartford Hospital
RECRUITING

Hartford, Connecticut, 06106, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact

Conditions

Explore the condition pages connected to this study.

FAMILIAL ALCOHOLISM VULNERABILITY

Conditions inferred from the trial description

These were inferred from the trial's summary, not listed by the trial registrant.

ALCOHOL USE DISORDER