Can a common blood thinner protect critically ill kids from catheter clots?

NCT ID NCT04924322

Recruiting now Disease control Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether enoxaparin, a blood thinner, can prevent blood clots caused by central venous catheters in critically ill children. Researchers will enroll 258 children up to 17 years old and adjust the dose based on age. The goal is to see if age affects how well the drug works, while monitoring for bleeding risks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Enoxaparin (a blood thinner, also known as Lovenox or Clexane)
What this could lead to: If successful, this could provide a safer, age-appropriate way to prevent dangerous blood clots from catheters in critically ill children, reducing complications.
What could go wrong: This is a mid-stage trial with 258 participants, so results may not apply to all children. Enoxaparin carries a risk of bleeding, which could be serious in critically ill patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Critical Illness Hemorrhage venous thromboembolism Venous Thrombosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEEP VENOUS THROMBOSIS

Contacts and locations

Locations

Arkansas Children's Hospital
RECRUITING

Little Rock, Arkansas, 72202, United States
Children's Hospital Colorado
RECRUITING

Aurora, Colorado, 80045, United States
Children's Hospital St. Louis
RECRUITING

St Louis, Missouri, 63110, United States
Children's Hospital Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Children's Hospital of Illinois at OSF Saint Francis Medical Center
RECRUITING

Peoria, Illinois, 61637, United States
Children's Hospital of Philadelphia
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Children's Hospital of Richmond
WITHDRAWN

Richmond, Virginia, 23219, United States
Children's of Alabama
RECRUITING

Birmingham, Alabama, 35233, United States
Dell Children's Medical Canter
RECRUITING

Austin, Texas, 78723, United States
Golisano Children's Hospital
RECRUITING

Rochester, New York, 14642, United States
Hassenfeld Children's Hospital
RECRUITING

New York, New York, 10016, United States
Johns Hopkins All Children's
RECRUITING

St. Petersburg, Florida, 33701, United States
Maria Fareri Children's Hospital
RECRUITING

Valhalla, New York, 10595, United States
Nationwide Children's Hospital
WITHDRAWN

Columbus, Ohio, 43205, United States
New York Presbyterian Hospital
RECRUITING

New York, New York, 10065, United States
Penn State Hershey Children's Hospital
RECRUITING

Hershey, Pennsylvania, 17033, United States
Stead Family Children's Hospital
RECRUITING

Iowa City, Iowa, 52242, United States
UH Rainbow Babies & Children's Hospital
RECRUITING

Cleveland, Ohio, 44106, United States
UTSW Medical Center; Children's Medical Center of Dallas
RECRUITING

Dallas, Texas, 75235, United States
University of Florida -UF Health
RECRUITING

Gainesville, Florida, 32610, United States
University of Oklahoma
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
Yale-New Haven Children's Hospital
RECRUITING

New Haven, Connecticut, 06520, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.