Can a month of pills boost radiation for prostate cancer?

NCT ID NCT06111781

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether adding a short, 30-day course of the oral hormone drug Relugolix to standard targeted radiation (SBRT) works better than radiation alone for men with intermediate-risk prostate cancer. About 60 men will be randomly assigned to one of the two treatments. The main goal is to see if the combination leads to a lower PSA level after treatment, while also tracking side effects and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Relugolix (Orgovyx) and stereotactic body radiotherapy (SBRT)

What this could lead to

If successful, this could show that a short 30-day course of Relugolix plus SBRT controls prostate cancer better than SBRT alone, with fewer side effects than longer hormone therapy.

What could go wrong

This is a small Phase 2 trial with only 60 participants, so results may not apply to all patients. The short hormone course might not be enough to improve outcomes, and side effects from Relugolix or SBRT are possible.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Memorial Sloan Kettering Cancer Center

    RECRUITING

    New York, New York, 10017, United States

    Contact

    Contact Email: •••••@•••••

  • University of Washington

    RECRUITING

    Seattle, Washington, 98109, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Yale Cancer Center

    RECRUITING

    New Haven, Connecticut, 06520, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact