Can supplements rewire your genes? new study investigates

NCT ID NCT06931977

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed study looked at whether taking a set of dietary supplements (including a nutrient drink, omega oils, probiotics, and copaiba oil) along with lifestyle changes can influence gene expression and blood markers in 97 healthy adults aged 30-55. Participants took the supplements daily for 12 weeks and provided blood, urine, and stool samples. The goal was to see changes in gene methylation, vitamin D, inflammation levels, and overall wellness measures.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dietary supplement system (VMG+ nutrient complex, EO Mega+ omega complex, PB Restore probiotic, and Copaiba essential oil softgels)
What this could lead to
If successful, this study could show that natural supplements and lifestyle changes can positively influence gene activity and health markers in healthy people.
What could go wrong
This is a small, completed trial in healthy volunteers, so results may not apply to people with health conditions. The effects are likely modest and need further research to confirm.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

97 people

The number who actually took part.

Started

Apr 2025

Finished

Sep 2025

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

30 to 55 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults ages 30-55 years old * Willing to attend three study visits at Prime Meridian Health Clinic in Pleasant Grove, Utah * Willing and able to undergo three blood draws over 12 weeks * Willing to provide urine and stool samples three times over 12 weeks * Willing to wash out of all internally consumed essential oils or botanical products for at least 2 weeks prior to starting the study, and willing to maintain the washout for the duration of the study (14 weeks). * Willing to wash out of all fish oil supplements, probiotic supplements, and greens powder mix 2 weeks prior to starting the study, and willing to maintain the washout for the duration of the study (14 weeks). * Willing and able to consume study product as directed daily for about 12 weeks * Willing to track consumption of study product * Willing to implement changes to diet, exercise, and sleep habits for 12 weeks * Willing to avoid alcohol, recreational drugs, and smoking/vaping for the duration of the study (approximately 12 weeks) * Own a smartphone or tablet and willing to download the fitness tracker app * Willing to wear a fitness tracker for the duration of the study (approximately 12 weeks) * At least 110 pounds * No metabolic disease (BMI\>35, diagnosis and treatment of * hypertension, diabetes, or dyslipidemia) * No major diseases under treatment by doctor (Medical Reviewer's * discretion) * No pregnancy within the last 60 days or currently breastfeeding * (females) * No allergy to any of the ingredients in the study products * No regular internal consumption of the study products within the last 1 month (regularly is defined as dosing daily for more than 2 consecutive weeks, or dosing more than 2-3 times per week for 4 consecutive weeks) * No alcohol, recreational drug, or smoking/vaping use in the past 1 month * No evidence of medical condition, significant disease or disorder, medication, or surgery within the past 12 months that may, in the judgment of the medical provider, put the participant at risk or affect study results, procedures, or outcomes * Not currently or previously participating in any other clinical trial within the last 30 calendar days Exclusion Criteria: * Failure to meet all listed inclusion criteria

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Healthy are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • doTERRA International

    Pleasant Grove, Utah, 84062, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.