HEALTHY

This study tests a vaccine given to healthy pregnant women to see if it can protect their babies from group B streptococcus (GBS), a bacteria that can cause serious illness in newborns. About 6,000 women will receive either the vaccine or a placebo shot during pregnancy. Research…

This study tests a new dengue vaccine called V181 in 12,000 healthy children aged 2 to 17. The goal is to see if the vaccine is safe, triggers a good immune response, and lowers the number of dengue cases. Participants will receive either the vaccine or a placebo and be monitored…

This early-stage trial tests two experimental vaccines (V350A and V350B) designed to protect against Epstein-Barr virus, which can cause mono and is linked to certain cancers and multiple sclerosis. About 250 healthy adults will receive either the vaccine or a placebo to see if i…

This study compares a new nasal spray COVID-19 booster vaccine (LVT-001) with a standard mRNA booster shot in 238 healthy adults. The goal is to see if the nasal spray is safe and can boost immunity, especially in the nose and airways. It's a first-in-human trial, so it starts wi…

This study tests a new vaccine called V118E, designed to protect against Streptococcus pneumoniae bacteria, which can cause serious infections like pneumonia. Researchers want to see if it is safe and well-tolerated in healthy adults. About 126 participants will receive either th…

This study checks if two different versions of the drug survodutide are absorbed the same way in the body. About 80 healthy adults with overweight or obesity will receive both formulations in a random order. The goal is to see if they work equally well, which helps decide which v…

This early-stage study tests a new drug called XmAb657 in 60 people, including healthy volunteers and those with autoimmune diseases like scleroderma or Sjögren's. The main goal is to see if the drug is safe and tolerable when given as a shot under the skin. Researchers will also…

This early-phase study tests whether fecal microbiota transplantation (FMT) can improve both gastrointestinal and autism-related symptoms in people aged 7–30 with autism spectrum disorder (ASD) and gut problems. Researchers will give FMT to 60 participants and track changes in gu…

This early-stage study tests a new oral medication, BGM0504, in 75 healthy and non-diabetic overweight or obese Chinese adults. The main goal is to check safety and how the drug moves through the body. Participants will take either the drug or a placebo, and researchers will moni…

This early-stage study tests the safety of a new drug called IBI3013. First, healthy volunteers receive a single dose to check for side effects. Then, people with active vitiligo (patchy skin color loss) or severe alopecia areata (patchy hair loss) receive multiple doses over up …

This early-stage study tests a new medicine called LY4298445 in healthy volunteers and people with lupus or rheumatoid arthritis. The main goal is to check if the drug is safe and how the body processes it. About 63 participants will be involved, and the study lasts up to a year.

This early-stage study is testing a new drug called LY3938577 in healthy volunteers and people with type 1 diabetes. The main goals are to see how the drug moves through the body, how safe it is, and whether it can lower blood sugar compared to a standard insulin. The study has f…

This early-stage study tests a new drug called LY4006895 for safety and how the body processes it. It involves 128 people: healthy volunteers receiving a single dose, and patients with early Alzheimer's receiving multiple doses. The goal is to check for side effects and measure d…

This early-stage study tests an experimental drug called LY4086940 in healthy people and those who are overweight or have obesity, with or without type 2 diabetes. The main goal is to check the drug's safety and how the body processes it. About 216 participants will take part in …

This early-phase study tests a new drug called LY4064912 in 144 healthy adults and people with overweight or obesity. The main goal is to check if the drug is safe and what side effects it may cause. Participants will receive the drug as a shot under the skin or through an IV, an…

This study looks at whether a weekly low-dose rapamycin pill (everolimus), resistance training (like lifting weights), or both can improve bone formation and muscle function in women aged 60-75 who have lower bone density but not osteoporosis. About 148 women will be randomly ass…

This early-stage study tests the safety and how the body handles a new drug called LY3549492 in 120 healthy adults who are overweight or have obesity. Participants will receive multiple doses of the drug and be monitored for about 8 weeks. The goal is to see if the drug is safe a…

This study tests a new capsule camera attached to a string that is gently moved up the lower gut to take pictures. It aims to see if the device can get clear images without needing sedation. The study includes 30 healthy adults and people with Lynch syndrome or inflammatory bowel…

This study compares a new cuff-less wrist wearable (ViTrack) to standard cuff-based blood pressure devices. About 91 healthy adults with normal or high blood pressure will participate. The goal is to see if the wrist device measures blood pressure accurately and check for any ski…

This early-stage study tests a new imaging agent called NeuCaVis in 12 healthy volunteers. NeuCaVis is designed to make PET scans clearer by highlighting areas of inflammation, which could help doctors spot diseases more easily in organs like the brain and heart. Participants wil…

This study explores a new blood test that looks for DNA fragments released by damaged heart cells. The goal is to detect active heart inflammation in people with sarcoidosis, a condition that can cause serious heart problems. Researchers will compare results from sarcoidosis pati…

This study is testing a new automated MRI method to see if it can produce clearer images of the liver. It involves 200 participants, including healthy adults and people with known or suspected liver disease or iron overload. Participants will have one MRI scan, and researchers wi…

This study is testing a device called Inflammacheck® that measures certain chemicals in your breath to see if it can tell the difference between people with lung cancer, other lung diseases like pneumonia, and healthy individuals. The goal is to create a quick, painless, and affo…

This study is testing a new portable ultrasound device that measures bone density in the lower leg without using radiation. Researchers will compare its results to the standard X-ray method (DXA) in 350 healthy men and women aged 21 to 55. The goal is to see if the ultrasound dev…

This study tests two light-based techniques (diffuse reflectance spectroscopy and photoacoustic imaging) to see if they can tell the difference between healthy, benign, and malignant breast tissue. About 90 adults with a breast tumor larger than 1 cm will be scanned, and the resu…

This study tests a new injection called [18F]LY4214835 to see if it is safe and how it spreads in the body. It includes both healthy volunteers and people with cancer. The goal is to improve cancer imaging, not to treat the disease. Participation lasts about 35 days.

This study looks at whether taking a daily carotenoid supplement (a type of nutrient found in colorful fruits and vegetables) can help protect the retina, the light-sensitive part of the eye. Researchers will measure eye structure, vision, and even memory in 50 healthy adults ove…

This study aims to create and test a home safety program for Latinx families with children ages 15 months to 5 years. Researchers will work with community centers to adapt an existing program and then test it with 100 caregivers. The goal is to see if the program helps parents su…

This study tests whether adding technology like a website and virtual coaching to basic education and goal-setting helps older adults (60+) who live alone and have mild memory concerns become more physically active. Participants wear a Garmin tracker, set weekly step goals, and c…

This study looks at whether it's better to give the RSV and Tdap vaccines together at one visit or separately at different visits during pregnancy. Researchers want to see if a larger trial is possible and will check safety and immune responses. About 60 healthy pregnant individu…

This study tests whether taking Bragg apple cider vinegar before a high-carb meal can lower blood sugar spikes in healthy adults aged 20-50. Twenty-four participants will drink either vinegar or water, then have their blood drawn to measure glucose and insulin. The goal is to see…

This study is testing a drink made with caprylic acid and omega-3 fatty acids to see if it helps muscles recover strength and reduce fatigue after intense exercise. Researchers will compare the drink to a placebo in 28 healthy, young men. The goal is to develop a food supplement …

This study looks at whether eating grapes can help improve muscle strength and thinking skills in healthy women aged 65 and older. Participants will come to campus for four sessions to do strength tests, thinking tests, and blood draws. The goal is to see if a simple dietary chan…

This study tests whether a special vacuum dressing (closed incision negative pressure therapy) helps wounds heal better after breast reduction surgery compared to a standard bandage. About 92 women having the surgery will each have one breast treated with the special dressing and…

This study tests whether special breathing exercises (inspiratory muscle training) can help amateur CrossFit athletes improve their performance and reduce fatigue. 94 healthy adults aged 18-60 who do CrossFit will either do breathing training with a resistance device or a sham de…

This study looks at whether eating grapes rich in flavonoids can help protect brain blood flow, thinking skills, and blood vessel health during mental stress in healthy young adults aged 18-40. Participants will eat either high-flavonoid grape powder or a low-flavonoid control be…

This early-stage study tests a new drug called LY4057996 in healthy volunteers and people with type 1 or type 2 diabetes. The main goal is to see if the drug is safe and what side effects it may cause. Researchers will also measure how the body processes the drug and its effect o…

This study looks at whether staying active and mobile during labor can improve birth outcomes for first-time mothers with low-risk pregnancies. Researchers will compare standard care to care that includes a special birth mobility system. The main goal is to see if moving more can…

This early-stage study tests a new drug called LY4213663 in healthy volunteers and people with rheumatoid arthritis (RA). The main goal is to see if it is safe and what side effects may occur. Researchers will also measure how the body processes the drug. The study lasts about 33…

This study tests whether a science-based app called Flourish can improve well-being, reduce loneliness, and increase belonging among college students. About 2500 students will be randomly assigned to use the app alone, use it with a buddy, or continue with their usual resources f…

This study tests whether adding lactase to milk helps premature babies (born 28-34 weeks) digest lactose better and gain weight faster. About 100 newborns will receive either lactase-fortified milk or regular milk, and their weight gain will be compared. The goal is to improve nu…

This study tests whether a krill oil supplement called Lysoveta can improve memory in healthy adults aged 50 to 75 who feel their memory is slipping. Participants will take either Lysoveta or a placebo for about 4 months and complete computer-based memory tests and mood questionn…

This early study tests MK-4082, a new weight loss pill, in 120 healthy overweight or obese adults. The goal is to find a safe dose and see how the body handles it. Unlike many weight loss drugs that are injections, this one is taken as a pill. The study focuses on safety and side…

This early-stage study tests an experimental drug called SP-624 in 36 adults—some healthy and some with major depression. Participants take the drug or a placebo daily for two weeks. Researchers use EEG brain scans and AI to see if SP-624 changes brain activity or improves memory…

This study looks at whether giving children a small incentive (like a prize) after a medical procedure can lower their anxiety. About 187 children aged 6 to 17 who are having a procedure and are supported by a child life specialist will take part. Their anxiety will be measured b…

This study tests whether a multi-strain probiotic supplement called Smile Probio 45B is easy for healthy adults to take and whether it helps with digestion, energy levels, and overall well-being. Forty healthy adults will take the probiotic daily for 30 days, record their bowel h…

This early-stage study tests an experimental injection called LY3971297 in healthy volunteers and people with obesity and high blood pressure. The main goal is to check for side effects and see how the drug moves through the body. About 225 participants will be involved, with stu…

This study tests whether a supplement called citicoline can improve mood in healthy adults who have moderate mood issues. About 90 people will take either citicoline or a placebo daily for several weeks. Researchers will measure mood, sleep quality, stress, and certain blood mark…

This study looks at whether drinking an olive extract (OliPhenolia®) for 8 days helps healthy, active adults burn more fat during cycling. It also checks if having caffeine before exercise makes the effect stronger. About 40 volunteers will take part. The goal is to see if this n…

This study looks at how a drug called LY3537031 is absorbed and cleared from the body in people with mild, moderate, or severe liver problems compared to healthy volunteers. About 32 adults will receive a single injection under the skin. The goal is to understand safety and drug …

This early-stage study tests the safety and tolerability of a single dose of M5542 in 49 healthy adults. Participants receive either the drug or a placebo, and researchers monitor for side effects, how the drug moves through the body, and immune responses. No treatment benefit is…

This study looks at how a single 30-minute exercise session affects appetite and hunger-related hormones in healthy men who are also cutting calories. Researchers will compare three groups: one with no restrictions, one with severe calorie cutting, and one with severe calorie cut…

This study looks at how certain drinks change amino acid levels and appetite hormones after a meal in healthy adults aged 20 to 50. Researchers will measure blood levels of these substances over time. The goal is to understand the body's response to the beverages, not to treat an…

This study looks at how two different capsule forms of the drug varegacestat are absorbed by the body. It involves 20 healthy adults aged 18 to 55 who do not smoke. Participants will receive both forms in a random order, and researchers will measure drug levels in the blood to se…

This study looks at how growth hormone affects beta-cells, which make insulin and control blood sugar, in people with a family history of type 2 diabetes. Researchers will compare two groups of 30 adults with obesity—those with and without a family history of diabetes. The goal i…

This early-stage study tests a new medicine, PF-07985631, in healthy adults to see if it is safe and how the body processes it. The medicine is being developed for a kidney disease called IgA nephropathy. Participants receive either the drug or a placebo as an injection or IV, an…

This study looks at how kidney blood flow changes during exercise in healthy young African American adults compared to White adults. Researchers want to understand why African Americans face higher risks of heart and kidney problems. Participants will do cycling, cold hand tests,…

This study looks at how healthy adults' brains process both emotions and time when viewing emotional images. Researchers will use brain scans (fMRI) and mild magnetic stimulation (TMS) to find which brain regions track these signals and guide actions. The goal is to understand ba…

This study translates and tests health questionnaires for Albanian-speaking adults with muscle or joint pain, back pain, or movement issues. Researchers will check if the translated scales are accurate and reliable by asking 300 participants to complete them. The goal is to give …

This study looks at whether teaching young adults to eat more potassium-rich foods is easier and more effective for blood vessel health than telling them to eat less salt. Researchers will compare two groups: one focused on boosting potassium, the other on cutting sodium. The goa…

This study aims to understand how being overweight or obese changes the way your blood pressure responds during different breathing maneuvers and exercise. Researchers at Florida State University will measure blood pressure in 80 healthy adults at rest and during aerobic and brea…

This early-stage study is testing a new drug called BI 3814916 in 136 healthy adults aged 18 to 65. The main goal is to see if the drug is safe and how the body processes it. Participants will receive either the drug or a placebo, and no direct health benefit is expected from tak…

This study looks at how short (10 minutes) and longer (30 minutes) exercise sessions affect appetite, hunger-related hormones, and how much food healthy men eat after a meal. Researchers will compare these exercise sessions to a no-exercise control group. The goal is to understan…

This study looks at whether brain signals can predict when someone will make a mistake during a typing task, up to 1 second before it happens. Researchers will use brain scans (MRI and MEG) to measure activity in healthy right-handed adults aged 18 to 35. The goal is to understan…

This study explores whether using an AI chatbot (like ChatGPT) can improve the clinical reasoning skills of physical therapy students. Sixty healthy students will be randomly assigned to either practice with the AI or follow standard teaching methods. The goal is to see if AI can…

This early-stage study is testing a new drug, IBI3032, in 32 healthy adults to see if it is safe and how the body processes it. Participants receive a single dose of the drug or a placebo and are monitored for 15 days. This study is for research only and is not meant to treat any…

This study looks at whether salbutamol, a common asthma medication, can improve exercise performance in non-asthmatic endurance athletes. Researchers will test 64 healthy, highly fit runners or cyclists to see if the drug helps them exercise longer. The goal is to understand if a…

This study aims to understand how healthy bone marrow plasma cells use a nutrient called glutamine. Researchers will give a special labeled form of glutamine to 20 healthy adults aged 18-60, then take a small bone marrow sample to measure how the cells process it. The goal is to …

This study looks at how taking sialic acid by mouth changes the bacteria in your gut, especially harmful ones like E. coli. Researchers will compare gut bacteria in healthy adults who take sialic acid versus those who don't. The goal is to learn how sialic acid might help keep th…

This study tests whether a home-based mobile app can help 3-4 year olds who currently don't meet healthy movement, sleep, and screen-time goals. About 80 children will wear activity trackers while parents use the app for weekly tips and goals. Researchers will compare them to a w…

This early-stage study is testing a new drug called BI 3821001 in healthy men aged 18 to 55. The main goal is to see if it is safe and how the body processes it. Participants receive a single dose and are monitored for side effects. This study does not aim to treat any disease.

This study tests a new neck-strengthening device called TopSpin360 in 60 junior hockey players. Researchers want to see if it improves neck strength and measures of brain function, like reaction time. Participants must be healthy, fluent in English, and cleared to play hockey. Th…

This study looks at whether current protein recommendations for children ages 8-10 are too low, especially for kids who are very active and fit. Researchers will measure how the body uses protein in 30 normal-weight children with different activity levels. The goal is to better u…

This study looks at whether doing the "Xuong tan lac than" exercise for 12 weeks can improve joint flexibility and muscle endurance in healthy adults. About 34 volunteers will practice the exercise daily and get their range of motion and muscle strength tested over time. The goal…

This study looks back at medical records and brain MRI scans from up to 2000 children (20 years old or younger) to create computer models that link brain images with genetic information. The goal is to better understand and predict developmental disorders. No new treatments or pr…

This study tests a new imaging tool that gives surgeons a live, 3D view inside the eye during surgery. It includes up to 262 people with various eye conditions like retinal detachment, cataracts, or macular holes, as well as healthy volunteers. The goal is to see if this technolo…

This study is testing a new drug called LY4066708 in healthy people to see if it is safe and how the body handles it. About 104 participants will receive either a single dose or multiple doses of the drug. The study lasts up to 24 weeks and focuses on side effects and drug levels…

This study explores whether a specific type of acupuncture (electroacupuncture) at two points on the body can affect how often the bowels move. Thirty healthy adults will have their bowel sounds recorded before, during, and after the acupuncture using a special digital stethoscop…

This study looks at adults who carry one copy of the PKU gene but are not sick themselves. Researchers want to see if their brains handle the amino acid phenylalanine differently than people without the gene. Participants will take phenylalanine or a placebo and then have brain s…

This study is checking if taking a supplement called PEA (palmitoylethanolamide) every day for a year is safe for healthy adults. About 200 people aged 18 and older will either get PEA or a placebo pill, and neither they nor the researchers will know who got which. The main goal …

This study is testing whether wearable devices worn on the wrist or trunk can accurately measure movement problems like chorea and walking changes in people with Huntington's disease. About 100 participants, including those with Huntington's and healthy volunteers, will wear the …

This study looks at whether quitting cannabis for at least 4 weeks can improve brain cell connections in people with cannabis use disorder. Researchers will use brain scans and memory tests to compare changes in cannabis users versus healthy non-users. The goal is to understand h…

This study looks at how caffeinated beverages affect mood and body in healthy adults who already drink caffeine regularly. About 150 people aged 18 to 55 will try different drinks and rate their feelings. The goal is to understand the effects of caffeine, not to treat any disease…

This study uses a special PET scan tracer to measure the density of synapses (connections between brain cells) in people with psychotic disorders or cannabis use disorder, compared to healthy volunteers. Researchers aim to understand how synaptic density relates to thinking abili…

This study looks at how certain dietary supplements might change proteins in the immune system of healthy adults. Researchers will give volunteers either a supplement or a placebo and then analyze their blood to see if there are any changes. The goal is to understand how these su…

This study tests whether new MRI software can improve the speed or quality of images taken during MRI-guided ablation procedures. Researchers will enroll 100 healthy volunteers and patients already scheduled for such procedures. The goal is to see if the new technology helps doct…

This study looks at how a gentle brain stimulation technique called tDCS affects attention and thinking. Researchers will test healthy adults and people with schizophrenia using cognitive tasks and brain wave recordings. The goal is to understand brain function, not to treat any …

This study is testing a new imaging device called Electrical Impedance Tomography (EIT) that uses harmless electrical currents to create pictures of the lungs, without any radiation. Researchers want to see if it can help monitor lung function in children with chronic breathing c…

This early-stage study checks if a new experimental HIV medicine, MK-4646, changes the amount of standard HIV drugs (BIC/FTC/TAF and dolutegravir) in the blood. It involves 16 healthy adults and focuses on safety and how the drugs interact. The results will help guide future stud…

This study looks at how people who speak two languages or a spoken and sign language control which language they use. Researchers will have 360 healthy adults complete tasks like naming pictures or sorting words in different languages. The goal is to understand how the brain swit…

This study looks at how the drug BI 1291583, being developed for the lung disease bronchiectasis, is processed in people with and without liver problems. About 32 adults aged 18 to 80 will take a single dose of the drug. Researchers will measure drug levels in the blood and monit…

This early-stage study tests the safety of a new drug, LTG-001, in healthy adults aged 18 to 55. Participants will receive either the drug or a placebo by mouth or through a vein. The goal is to see how the body handles the drug and check for side effects, not to treat any diseas…

This study tests whether a single dose of vicadrostat changes the heart's electrical signals compared to a placebo. It involves 45 healthy adults aged 18 to 50. The goal is to ensure the drug is safe for the heart before moving to larger trials.

This study is for 80 healthy adults aged 18-64. Researchers want to test a new way to stimulate the brain using focused ultrasound, guided by brain wave readings (EEG). The goal is to see if this method can safely and precisely affect brain activity. This is a research study, not…

This study is testing a new, easy-to-use portable breathing device that could be used by people without medical training during breathing emergencies. The device delivers continuous positive airway pressure (CPAP) to help keep oxygen levels up. Researchers will have 50 healthy ol…

This study looks at how brain activity changes during emotional and memory tasks in both healthy volunteers and people with depression. Researchers use brain scans and gentle brain stimulation to understand these patterns. The goal is to create better, more personalized treatment…

This early-stage study is the first time the experimental drug CAY001 is being tested in humans. The main goal is to see if it is safe and how the body handles it. About 24 healthy adults will receive either a single dose of CAY001 or a placebo by IV. Researchers will monitor for…

This study is testing a new, smaller minitablet version of the drug obefazimod in 44 healthy adults aged 18 to 55. The goal is to see how the body absorbs the minitablet compared to the current capsule and whether it tastes okay. This is an early-stage study to help develop a chi…

This study tests whether a brain-training technique called real-time fMRI neurofeedback can help healthy adults reduce the return of learned fears. Participants will learn to control a brain connection linked to memory while inside an MRI scanner. The goal is to see if this train…

This study compares two ways of using real-time brain scans (fMRI) to help healthy adults learn to control a brain region linked to emotions and body awareness. 90 participants will receive either continuous or intermittent feedback on their brain activity. The goal is to see whi…

This study looks at how the drug mirdametinib is processed in the body by comparing people with moderate or severe liver problems to those with healthy livers. About 32 adults aged 18 to 80 will take part. The goal is to gather information only, not to treat any condition.

This study checks if a new algorithm can correctly identify irregular heartbeats in healthy adults aged 18 to 80. Researchers will compare readings from finger and wrist sensors to a standard heart monitor. The goal is to see how accurate the new method is without any heart disea…

This study looks at whether carbon fiber insoles can help moderately active men jump higher and sprint faster. About 38 men aged 18-30 will do tests with and without the insoles. Researchers will measure jump height, sprint time, and how the insoles feel. The goal is to see if th…

This early-stage study is testing an experimental pill called AS-S603, designed to break down protein clumps linked to Alzheimer's disease. The trial involves 88 healthy adults and elderly volunteers to check the drug's safety and how the body processes it. No treatment benefit i…

This study checks how well the Owlet OSS 3.0-M1 sensor measures pulse rate and blood oxygen levels in healthy children aged 19 months to 5 years. About 90 kids will wear the sensor while their readings are compared to a standard medical device. The goal is to see if the Owlet sen…

This study looks at whether blood flow in fat tissue changes as we age. Researchers will compare healthy younger adults (18-35) and older adults (65-80) by measuring blood flow, taking small fat samples, and having participants drink a sugary drink. The goal is to understand basi…

This pilot study in 12 healthy volunteers aims to see if biological sex influences how quickly people recover from unconsciousness caused by dexmedetomidine, a common sedative. Researchers will also test whether a combination of brain stimulation and EEG can measure brain activit…

This study looks at whether brain activity tests can predict if a person with depression can safely stop taking antidepressants without relapsing. About 204 participants will have brain scans, sleep tests, and blood samples taken during treatment. Researchers hope to find biologi…

This study translates and tests a questionnaire (CCSTQ) for Turkish women to understand the psychological and social factors that influence their decision to get screened for cervical cancer. Researchers will enroll 215 women aged 21-65 who speak Turkish and are sexually active. …

This early-stage study tests whether SYNT-101 is safe and how the body processes it. It involves 64 healthy adults, including some who are overweight or have obesity. Participants receive either the drug or a placebo. The goal is to check for side effects and measure drug levels …

This study checks if people can collect their own blood samples at home to measure levels of urolithin A, a compound found in some foods and supplements. About 250 healthy adults aged 18-80 will take Mitopure and use a special kit to provide dried blood spots. The goal is to see …

This study compares two types of lasers used for skin treatments: a new DFG laser and the standard CO2 laser. Researchers want to see if the DFG laser causes less pain and helps the skin heal faster. About 23 healthy adults will receive both laser treatments on small areas of ski…

This study explores whether a non-invasive brain stimulation technique can help healthy adults quickly achieve a deep meditative state, normally requiring years of training. Participants will wear an EEG cap, undergo brain stimulation, and perform a guided meditation task. The go…

This early-stage study tests the safety of a new medicine, PF-08057418, in healthy adults aged 18 to 60. Participants receive the drug once a week for 5 weeks as a solution or tablet. Researchers monitor side effects and how the body processes the drug. The goal is to gather basi…

This study looks at how HIV may damage the brain even when the virus is controlled with medication. Researchers will use special PET and MRI scans to measure brain cell connections and inflammation in 70 people with and without HIV. The goal is to better understand why some peopl…

This study looks at whether spending a lot of time on social media is linked to unhealthy exercise habits in young adults. Researchers will survey 187 university students aged 18-24 who use social media at least 4 hours daily. The goal is to understand the connection between digi…

This study looks at how natural changes in the hormone estradiol during the menstrual cycle might change the way the spinal cord adapts. Researchers will use mild electrical pulses to test spinal responses in 50 healthy young adults. The goal is to understand basic biology, not t…

This study at the University of Oxford looks at how pimavanserin, a drug that blocks a specific serotonin receptor in the brain, affects memory, emotional processing, and decision-making in healthy adults aged 18-45. By comparing the drug to a placebo, researchers hope to learn m…

This study looks at whether using telemedicine (video visits) can help people who are thinking about donating a kidney learn about the process and make better decisions. About 70 adults in California who are registered as potential kidney donors will take part. Researchers will c…

This study tests whether a nasal spray containing oxytocin (the 'love hormone') can help healthy adults better control a specific brain region called the anterior insula during real-time brain scans. Participants will practice focusing on internal body sensations while receiving …

This study looks at how common topical medications like antifungal creams, mild steroid ointments, and moisturizers change the community of bacteria living on healthy skin. Researchers will track these changes over a short period in 24 adults. The goal is to understand whether th…

This study looks at whether a computer-animated character that explains medical illustrations helps people understand them better and feel less anxious. About 300 healthy adults will either view the illustrations alone or with the character on a screen or in virtual reality. The …

This study tests fisetin, a natural compound found in fruits, in healthy young adults and older people with multiple chronic diseases. Participants take fisetin or a placebo for two days and are followed for up to three months. The goal is to see how the body processes fisetin, w…

This study looks at how strong and how well the tongue moves in healthy children ages 4 to 17. Researchers will measure tongue pressure and check for any movement limits using simple tools. The goal is to collect normal values that can help doctors better understand tongue proble…

This study looks at healthy Somali Americans to find hidden sleep problems and see if they are linked to higher blood pressure. Researchers will measure sleep quality and blood pressure over 24 hours. The goal is to understand why this group may be at risk for hypertension.

This study tests a new virtual reality system that uses mirror therapy to help people recover arm movement after a stroke. Researchers will check how comfortable and easy the system is to use in 172 healthy adults and stroke patients. The goal is to see if this VR approach is pra…

This study looks at whether measuring big toe strength can help doctors understand nerve damage caused by chemotherapy. Researchers will test a new device called ToeScale in 30 adults—some with nerve damage from chemo and some healthy. Participants will answer questionnaires and …

This early-stage study tests whether a new eye drop called BT01001 is safe and how it moves through the body. It involves 32 healthy adults aged 18 to 50. Participants receive either the eye drop or a placebo. The goal is to check for side effects, not to treat any disease.

This study explores whether brain-computer interfaces (BCIs) can help people with motor disorders—like spinal cord injury, stroke, or multiple sclerosis—control assistive devices just by thinking about moving. Researchers will use harmless electrical stimulation to the spine and …

This study looks at whether taking the blood pressure drug losartan changes how the body processes the antibiotic cephalexin. Researchers want to know if taking them together or three hours apart makes a difference. Twelve healthy adults will take both drugs at different times to…

This study looks at whether a training program that mixes mental tasks with physical exercises can improve thinking and movement in people who have had a stroke or have Moyamoya disease. Researchers will also use brain scans to see how the brain changes during these activities. T…

This study looks at whether a single injection of mirikizumab works as well as two injections in healthy adults. Researchers will check safety and how the body handles the drug. About 450 healthy participants will take part, and the study lasts around 15 weeks. This is an early-s…

This study watches how babies aged 6 to 24 months chew and move their mouths when eating infant cereals with different textures. Researchers want to see if adding small pieces changes chewing patterns. About 153 healthy children will be videotaped while eating to understand how o…

This study looks at how blood vessels react right after moderate or intense exercise in healthy adults and those with slightly high blood pressure (prehypertension). Researchers will measure artery stiffness and blood flow before and after exercise sessions. The goal is to better…

This early-stage study is testing a new drug called ZT003 in healthy adults and overweight volunteers to see if it is safe and how the body processes it. About 76 participants will receive either the drug or a placebo. The study does not aim to treat any disease, but to gather im…

This study tests a program called the Early Childhood Friendship Project (ECFP) in 600 preschool children. The goal is to see if it reduces aggression and bullying while boosting kindness and school readiness. Teachers will lead the program with coaching, and researchers will tra…

This study looks at people with a specific gene change (GBA1) who are at higher risk for Parkinson's disease. Researchers will use simple, non-invasive tests to find early warning signs that can appear up to 20 years before Parkinson's symptoms. The goal is to build a model that …

This early-stage study tests a new drug, CM383, in 30 healthy men to see how the body handles it and if it is safe. Participants receive a single dose either through a vein or under the skin. The goal is to gather information, not to treat any disease.

This study compares a 9-week group cycling program to a one-time training session for adults who rarely ride. Researchers want to see if the longer program increases cycling, improves health, and is cost-effective. About 268 participants will be tracked for a year.

This early-phase study tests the safety and tolerability of a single dose of HB0056 in 46 healthy adults aged 18 to 55. Participants are randomly assigned to receive either the drug or a placebo. The main goal is to check for side effects and how the drug moves through the body. …

This study looks at how kidney blood flow changes during exercise in healthy older African American adults compared to White adults. Researchers will measure blood flow while participants cycle, do a cold hand test, and solve math problems. The goal is to understand why African A…

This study collects detailed eye scans (OCT) from 180 people with healthy eyes or eye diseases like retinal disease, glaucoma, and corneal disease. The goal is to gather data to help researchers better understand these conditions. Participants must be 22 or older and have certain…

This early-stage study is testing an experimental drug called LY3867070 in healthy people to see if it is safe and how the body handles it. About 196 healthy adults will take the drug by mouth and have blood tests. This study does not aim to treat any disease—it is simply gatheri…

This study enrolls 60 healthy adults to see how the body processes two medicines—enlicitide and rosuvastatin—when taken as separate pills versus combined into one tablet. Researchers will measure drug levels in the blood over time. The goal is to understand if the combination pil…

This study looks at whether the phase of a woman's menstrual cycle changes how her body responds to sprint interval training. Researchers will compare two weeks of training done either in the follicular or luteal phase in 24 healthy, regularly menstruating women. The goal is to s…

This study looks at how an experimental medicine, PF-08653944, is processed by the body and whether it is safe in people with different levels of liver function. About 26 adults—some with healthy livers and some with mild, moderate, or severe liver issues—will receive a single in…

This early-stage study tests whether a new drug called BLKR201 is safe in healthy adults aged 18 to 55. Researchers will also see how the drug moves through the body and if food affects its absorption. Participants take the drug or a placebo and stay at a clinic for several days …

This study looks at how the bacteria in your gut might influence brain aging and diseases like Alzheimer's, Parkinson's, and multiple sclerosis. Researchers will compare 200 people—healthy young and older adults, plus those with early Alzheimer's, Parkinson's, or MS—using brain s…

This study is looking for 2000 healthy adults who have a close family member with a blood cancer like multiple myeloma. The goal is to find early warning signs of the disease by collecting blood samples and health data over time. Researchers hope this will lead to better ways to …

This early-phase study is testing a new drug called NSHO-101 in 24 healthy adults to see how the body processes it and whether it is safe. Participants must be in good health and willing to follow study rules. There is no direct treatment benefit; the goal is to gather important …

This study aims to understand how the brain responds to magnetic stimulation (TMS) when it is timed to match natural brain rhythms. Researchers will compare healthy older adults and people who had a stroke at least 6 months ago. The goal is to find ways to make brain stimulation …

This study aims to gather information on how the heart handles exercise in healthy adults and those with congenital heart disease. Researchers will measure blood pressure in the lungs during activity using a thin tube. The results will help doctors better understand and treat hea…

This study takes tiny tissue samples from the rectum of people with IBS and healthy volunteers to measure how gut nerves work. Researchers will use special imaging and lab tests to see how these nerves react to different substances and foods. The goal is to better understand what…

This study looks at how different caffeinated beverages change your mood and body responses. It involves 75 healthy adults aged 18-55 who already drink caffeinated drinks regularly. Participants will try a test beverage and rate their feelings using simple scales.

This early-stage study tests the safety and how the body handles a new drug, AZD1613, in 136 healthy adults, including people of Japanese and Chinese descent. Participants receive either the drug or a placebo, and researchers monitor for side effects and measure drug levels in th…

This study aims to see if cooling the quadriceps (thigh muscles) changes how nerves control them. Researchers will use special sensors to measure muscle signals in 24 healthy adults aged 18-35. The goal is to test if the measurement method works well, not to treat any disease.

This early-stage study looks at how a single dose of ulonivirine changes the way the body processes atorvastatin and metformin. It involves 12 healthy adults and aims to measure drug levels in the blood over time. The results will help guide future use of ulonivirine with these c…

This early-stage study tests whether a new cream called JW0061 is safe for the skin and body. About 104 healthy Korean and Caucasian adults will receive either the cream or a placebo. The goal is to check for side effects and skin reactions, not to treat any disease.

This study looks at how the experimental drug PF-07328948 is handled by the body in people with normal or reduced kidney function. About 28 adults aged 18-80 will take a single dose and be monitored for safety and drug levels. The goal is to understand if kidney problems change h…

This study looks at how the medicine BI 3000202 behaves in the body of people with liver problems compared to healthy people. About 44 adults aged 18 to 80 will take a single tablet and have their blood tested regularly. The goal is to understand if liver issues affect drug level…

This study looks at how quickly healthy people convert EPA (an omega-3) into DHA, and whether biological sex and certain genes affect that process. 64 healthy adults will take EPA supplements for 12 weeks and give blood samples. The goal is to better understand individual differe…

This study checks if a new medicine called MK-2828 changes how the body processes two common drugs: rosuvastatin and furosemide. It involves 39 healthy adults and is part of early research for a potential heart failure treatment. The goal is to see if MK-2828 is safe to use with …

This study looks at how different levels of breathing exercises change oxygen levels in chest muscles. About 27 healthy, active adults will do breathing training at various intensities. Researchers will measure muscle oxygen before, during, and after each session using a special …

This study looks at how difficult childhood experiences might affect memory and brain function in people with opioid use disorder. Researchers will use brain scans and memory tests to compare three groups: people with opioid use disorder on buprenorphine, people without the disor…

This study tests a new imaging tracer to see if it can measure a specific enzyme (PDE4B) linked to brain inflammation in people with Alzheimer's disease or mild cognitive impairment. Researchers will compare brain scans from 90 volunteers aged 50 and older, including those with m…

This early-stage study tests a new inhaled drug called CPD704 in 90 healthy Chinese adults aged 18-55. The main goal is to see if the drug is safe and how the body processes it. Participants will receive either a single dose or multiple doses of the drug via a nebulizer. This stu…

This study aims to improve diagnosis for people with rare genetic diseases whose standard genetic tests came back normal. Researchers will use a technique called RNA-Seq on skin cells to find hidden genetic changes. The study involves 105 participants, including healthy volunteer…

This study looks at how the Q-Collar, a device already cleared by the FDA, changes the way blood flows to the brain when you rest and exercise. Twenty healthy adults aged 18 to 30 will do tasks like standing up quickly, breathing against resistance, and biking, while wearing the …

This early-stage study is testing a new drug called BI 3776528 in healthy male volunteers to see if it is safe and how the body handles it. About 142 men aged 18 to 50 will receive either the drug or a placebo. The goal is to gather safety information, not to treat any disease.

This study aims to develop better MRI techniques for looking at the heart and blood vessels, avoiding the need for radiation-based tests. Researchers will compare these new MRI methods with standard tests like angiography in up to 4,000 adults, including healthy volunteers and th…

This study looks at whether a special group exercise program called the Ideomotor Program can help healthy older adults think better, move better, and feel better. About 158 people aged 50 and older who live independently will take part in 16 weeks of classes, twice a week. Resea…

This observational study compares how prosocial behaviors (like helping and sharing) and brain connections develop in infants with a high or low risk of autism. Researchers will use developmental tests, EEG, and MRI scans during natural sleep to track differences. The goal is to …

This study looks at how quickly and how much the gut bacteria change in healthy adults when they take a fiber called chicory inulin. Researchers will compare the effects of inulin to a placebo (maltodextrin) over 6 weeks, then follow participants for another 6 weeks after stoppin…

This study looks at whether training your breathing muscles can also make your tongue stronger and more enduring. Researchers will measure tongue strength and endurance in 60 healthy adults before and after a period of respiratory muscle training. The goal is to understand if the…

This study tests a safe, non-invasive brain stimulation method called tDCS in healthy adults aged 20-40 and 60-80. Participants do computer tasks while receiving real or fake stimulation, and their brain activity is measured with MRI. The goal is to understand how age affects the…

This study looks at how your gut and brain work together to control hunger and fullness. Researchers will give healthy adults different types of food and measure brain activity and hormone levels. The goal is to better understand why we feel hungry or full, which could help with …

This study tests a new substance called [18F]-fluoromannitol, used in PET scans to help detect infections. Researchers want to see if it is safe and how it spreads in the body. Ten healthy adults aged 18 to 75 will take part. The goal is to gather safety data so the tracer can la…

This study enrolls 330 healthy adults to see if two different autoinjectors deliver the same amount of the drug tulisokibart into the body. Researchers will measure drug levels in the blood and check for side effects. The goal is to ensure both devices work equally well before fu…

This study looks at how paying attention differently during calf-strength exercises changes walking patterns and brain signals in healthy older adults. About 45 participants will do strength training and walk on a treadmill. The goal is to understand which focus strategy works be…

This study looks at how much harmful chemicals from fires get into firefighters' bodies. Researchers will collect urine and cheek cell samples from 60 firefighters before and after they fight a structural fire. The goal is to measure changes in toxin levels and better understand …

This study will collect and analyze genetic, metabolic, and microbiome data from over 6,000 adults with and without metabolic syndrome. The goal is to identify biological markers that predict disease progression and help guide future prevention and treatment. Participants will pr…

This study looks at how different levels of liver function affect the way the body processes a study medicine called PF-07328948. Researchers will give a single tablet to 26 adults, some with liver problems and some healthy, and monitor them for about 6 days. The goal is to under…

This study collects blood samples from 400 healthy adults aged 18 to 65 to learn how platelets work and how they may cause inflammation and blood clots in diseases. Participants must not have taken blood thinners in the past 10 days and must not have blood disorders. The goal is …

This study aims to understand what keeps the brain healthy as we age. Researchers will track 100,000 healthy adults over time using online tests and surveys. Participants also get access to brain training and educational resources. The goal is to learn how thinking, social habits…

This study looks at how the experimental drug PF-07328948 is absorbed and removed from the body. It involves 8 healthy men aged 18 to 64. The goal is to measure the drug in blood, urine, and stool after taking it by mouth or injection. No treatment or cure is being tested—just le…

This study collects health information, lifestyle details, and biological samples from up to 100,000 adults to help researchers learn more about conditions like lupus, celiac disease, kidney disease, and skin disorders. The goal is to find new biomarkers and improve future tests,…

This study looks at how psilocybin, the active ingredient in magic mushrooms, changes brain activity and the way people think. Thirty healthy adults will take either psilocybin or a placebo and then perform tasks like describing pictures or solving word puzzles while their brain …

This study looks at how the brain forms and links memories in healthy teenagers (13-18) and adults (19-25). Participants will do memory tasks during brain scans (fMRI) over time. The goal is to understand how brain development supports learning and inference, not to test a treatm…

This study looks at how a gentle electrical current applied to the brain (tACS) affects movement in people who had a stroke over 6 months ago. Researchers will test two different frequencies and a placebo to see which one best activates brain areas involved in movement. The goal …

This study aims to understand what causes Visual Snow Syndrome (VSS), a condition where people see constant flickering dots. Researchers will use brain scans and visual tests to find which brain pathways are involved. About 100 adults with VSS, migraine, or healthy vision will pa…

This study looks at how drinking milk or eating yogurt affects thinking and memory in healthy children ages 9 to 14. Researchers want to see if different types of dairy (varying in fat and protein) can improve focus, learning, and attention through signals between the gut and bra…

This study tests whether a single dose of oxytocin nasal spray changes how healthy people react to threats in a virtual predator-prey game. Researchers will measure escape success, decision-making, and brain activity in 80 volunteers. The goal is to understand how oxytocin influe…

This study looks at whether taking beetroot juice (which contains natural nitrate) before sleep can change how well you sleep and how your blood vessels work. Researchers will study 60 healthy adults, both younger (18-35) and older (65-80). The goal is to understand sleep and ner…

This study looks at how temporal lobe epilepsy (TLE) affects spatial memory, like remembering routes or locations. Researchers will compare 37 people with TLE and healthy volunteers using a navigation test, checking memory after 1 hour and again after 6 weeks. The goal is to unde…

This study tests a 9-month educational program for American Indian youth aged 12-18 that covers healthy relationships, puberty, pregnancy and STI prevention, substance use prevention, and positive mental health. It also involves caregivers and school staff. The goal is to see if …

This early-stage study looks at how a new version of an experimental drug is absorbed in the body. It involves 16 healthy adults who take the drug with or without food and with an acid-reducing pill. The goal is to gather information for future studies, not to treat any illness.

This study looks at how different types of strength training affect the brain and muscles. Healthy adults aged 18 to 40 will be assigned to one of three groups: training with a regular beat, training with a variable (fractal-like) beat, or training at their own pace. The goal is …

This study looks at how the brain, memory, thinking, and movement change over time in people with Lewy body disease, Alzheimer disease, and healthy volunteers. Researchers will use brain scans, brain wave tests, and thinking assessments to learn more about these disorders. The go…

This study looks at how growth hormone, with or without liraglutide (a diabetes drug), affects appetite, energy use, and blood sugar in healthy adults and those with growth hormone deficiency. About 40 people aged 18-45 will take each treatment for 21 days, with breaks in between…

This study tests a workshop called I CAN that teaches people how to work together to reduce cancer in their community. Researchers want to see if the program is practical and well-liked by participants. About 200 adults from Western New York will take part.

This study follows healthy women who are trying to get pregnant, as well as those who are not, to collect samples and track what happens in the first two weeks after fertilization. The goal is to learn how the mother and embryo communicate during this critical time, which may hel…

This study uses a special type of MRI, called hyperpolarized xenon MRI, to look at the lungs of 260 healthy young adults. The goal is to find early signs of lung problems that could lead to chronic disease later in life. Participants are already part of a larger lung health study…

This study looks at how the brain processes optimistic and pessimistic signals in healthy people and those with Parkinson's disease. Researchers will use MRI scans while participants play a game to see if these signals are different in Parkinson's. The goal is to better understan…

This early-stage study is testing a new drug, HY6725, in 74 healthy adults aged 18 to 55. The main goal is to see if the drug is safe and how the body processes it. Participants will receive either the drug or a placebo, and be monitored for up to 150 days. This trial does not ai…

This study looks at whether eating white potatoes at breakfast or dinner changes how your body handles blood sugar, how hungry you feel, and how many calories you eat later. Researchers will track 30 healthy adults using continuous glucose monitors and appetite surveys. The goal …

This study follows 800 pregnant people and their babies to see if how much they sit, move, and sleep during pregnancy affects the child's growth and heart health up to age 2. Researchers will track activity with monitors and measure babies' weight, waist size, and body fat. No tr…

This study aims to learn how the hormone insulin controls blood sugar in healthy volunteers and people at higher risk for type 2 diabetes. Participants will undergo a one-day test called the graded insulin suppression test (GIST), which uses medications and sugar infusions to mea…

This study creates and tests a training program for Care Food Specialists—workers who focus on food preparation and oral health in long-term care. About 150 healthy students in Taiwan will take the course and be assessed on their knowledge, attitudes, and behaviors before and aft…

This study aims to improve MRI technology for imaging the brain. Researchers will test new scanning methods on 1,100 healthy adults aged 18 and older. Participants will have yearly MRI scans and may perform simple tasks like listening to sounds or tapping fingers. The goal is to …

This early-stage study is testing a new drug, HY8931, in 60 healthy adults aged 18 to 45. The main goal is to see if the drug is safe and how the body processes it. Participants will receive either the drug or a placebo and be followed for up to 90 days.

This study is testing a new wireless capsule that you swallow to measure temperature inside your digestive tract. The goal is to see if it can help doctors find diseases like Crohn's disease. Ten healthy adults will take part to check if the capsule works correctly.

This study looks at how stroke changes the way people move their arms when walking. Researchers will measure brain activity and muscle patterns in 84 people (stroke survivors and healthy volunteers) to understand why arm swing is different after a stroke. The goal is to use these…

This early-stage study tests a new medicine called PF-07985631, which may one day treat a kidney disease called IgA nephropathy. About 76 healthy adults aged 18 to 55 will receive either the drug or a placebo as a small injection. The main goal is to check safety and how the body…

This study aims to better understand how many calories a person needs to eat to stay in energy balance—where weight stays steady. Researchers will use a special room called a whole-room calorimeter to measure energy burned and compare it to standard formulas. 34 healthy adults wi…

This study uses a special PET scan to measure brain inflammation in people with fibromyalgia, chronic fatigue syndrome, multiple sclerosis, and healthy volunteers. Researchers want to see if those with pain and fatigue have higher levels of brain inflammation. The study does not …

This study tests whether a low-dose fisetin supplement (100 mg daily for 7 weeks) is safe and can reduce signs of inflammation and aging in healthy adults aged 50 and older. Researchers will compare changes in blood markers and side effects between the supplement and placebo grou…

This study looks for brain signals that can predict how chronic low back pain changes over time. Researchers will use EEG, a non-invasive brain scan, to track brain activity in 130 adults with and without chronic back pain. The goal is to find patterns that could lead to better, …

This study aims to find out if children with primary ciliary dyskinesia (PCD) also have a condition called bronchial hyperresponsiveness, where airways tighten too easily. Researchers will measure lung function in 40 participants (30 with PCD and 10 healthy) using breathing tests…

This study looks at how eating berries, like cloudberries and lingonberries, affects tiny particles called extracellular vesicles that help cells communicate. Researchers will study 60 healthy adults to see if berries change these signals and gut bacteria. The goal is to learn mo…

This study looks at how a gentle, noninvasive nerve stimulation on the ear affects the brain and stomach. Researchers will use brain scans and stomach imaging to measure changes in activity. The goal is to understand how this stimulation works in healthy people and those with sto…

This early-stage study tests whether a new drug called IMP761 is safe in healthy adults aged 18 to 55. Participants receive either the drug or a placebo and are monitored for side effects and how the drug moves through the body. The study does not aim to treat any disease, but to…

This study tests a 21-day self-guided digital program designed to prepare healthy adults for a supervised psychedelic session with psilocybin. Forty volunteers will be randomly assigned to either a daily meditation or music-listening routine before taking a 25 mg dose of psilocyb…

This study looks at how well physiotherapy students learn important people skills like teamwork, leadership, and communication through simulated practice. About 100 second-year students and their teachers will rate these skills after each of nine simulation sessions. The goal is …

This study tests a new radioactive tracer called 11C-JMJ-129 to see how well it can highlight a protein called PDE4D in the brain and body. PDE4D is linked to thinking and mood, and may play a role in conditions like Alzheimer's and depression. Healthy adults aged 18 and older wi…

This study looks at how the body's immune cells react to a new type of cancer vaccine called a neoantigen vaccine. Researchers will collect blood samples from 24 people with solid tumors or healthy volunteers to study immune responses. The goal is to learn how to better grow and …

This study looks at how two natural compounds in food—oxalate and citrate—interact in the body and affect kidney stone risk. Researchers will measure changes in urine levels after giving potassium citrate to 24 adults, some with a history of kidney stones and some without. The go…

This study looks at how lepodisiran enters the blood and leaves the body in people with mild, moderate, or severe liver issues compared to those with healthy livers. About 33 adults will receive a single injection under the skin and be monitored for up to 9 weeks. The goal is to …

This study is creating a large collection of human biological samples and health information, called a biobank. Researchers will use these materials to study the causes of diseases like cancer, heart disease, and diabetes. Up to 10,000 participants will provide samples and data t…

This study aims to develop better ways to perform MRI scans by testing new imaging techniques in healthy volunteers and current NIH participants. Up to 1,000 adults aged 18 and older will have one or more MRI scans, each lasting 20 minutes to 2 hours, with some requiring contrast…

This study looks at how the body processes a drug called MK-1084 when the liver is not working normally. Researchers will give a single dose to people with liver impairment and to healthy volunteers, then measure drug levels in the blood over time. The goal is to understand if li…

This early-stage study enrolls 32 healthy volunteers to measure how much aramchol gets into the blood from two different single doses of a new tablet form. The goal is to compare the drug levels and choose the best dose for future studies. Participants are healthy adults aged 18-…

This early-stage study tests a new drug called LY4515100 in 40 healthy adults to see if it is safe and how the body processes it. Participants take the drug or a placebo and stay overnight for monitoring. There is no expected treatment benefit, as the goal is simply to gather saf…

This study looks at how young adults (ages 18-22) differ in their attention, impulse control, and brain responses to rewards. Researchers want to see if these differences are linked to cannabis use. Participants will complete tasks and brain scans to help understand these pattern…

This study looks at whether giving a mild electrical pulse to a nerve in the ear (called taVNS) after taking psilocybin can help people remember the deep thoughts and feelings they had during the experience. The idea is that the nerve zap might boost brain flexibility and memory …

This study is testing a new rehabilitation program for people with spinal cord injury (SCI) that combines walking downhill on a treadmill with mild electrical muscle stimulation. Researchers will check blood and spinal fluid for biomarkers to decide whether to start the program r…

This study looks at how the heart pumps blood and uses energy in healthy adults of different ages. Researchers will measure heart pressures and blood samples at rest and during exercise. The goal is to better understand normal heart function, not to test a treatment. About 80 hea…

This study tests whether a new tablet form of tafamidis works the same as the current capsule in healthy adults. About 24 participants will take each version once under fed conditions. The goal is to measure drug levels in the blood, not to treat any disease.

This study looks for shared genetic and chemical clues between eczema (atopic dermatitis) and food allergies. Researchers will collect blood and skin samples from 200 people, including those with food allergies, eczema, or neither. The goal is to create a molecular map that could…

This study tests whether a non-invasive brain stimulation technique called HD-tDCS can improve hand movement in healthy older adults. Researchers will compare a standard dose with a personalized dose tailored to each person's brain network. The goal is to understand how the brain…

This study is testing new wearable sensors made in a lab to see if they are comfortable and safe to wear. About 22 healthy adults will wear the sensors, and researchers will compare their readings of heart rate, breathing, and blood flow to approved medical devices. The goal is t…

This early-stage trial tests a new drug called BI 3804379 in healthy adults aged 18 to 65. The goal is to check if the drug is safe and how the body processes it. Participants receive either the drug or a placebo as a shot under the skin. The study does not aim to treat any disea…

This study tests whether taking the probiotic Lactobacillus rhamnosus GG (LGG) can prevent or reduce changes in gut bacteria caused by common acid reflux medications (PPIs). Researchers will compare stool samples from 30 healthy adults taking a PPI plus either LGG or a placebo. T…

This study looks at whether a person's natural thinking abilities can predict how well they learn to control a specific brain region using real-time fMRI. Forty healthy adults will practice regulating their brain activity while being scanned. The goal is to understand the link be…

This study collects small tissue samples from the abdominal lining of children and adults undergoing peritoneal dialysis. Researchers will study these samples to see how the lining changes over time and how different dialysis fluids affect it. The goal is to better understand the…

This study from Stanford University looks at why different people have different blood sugar responses to the same foods. Researchers will use continuous glucose monitors (CGMs) in 100 healthy adults, people with prediabetes, and those with type 2 diabetes to track blood sugar af…

This early-stage study tests the safety and tolerability of a new drug called DF5112 in 48 healthy adults aged 18 to 55. Participants receive either the drug or a placebo by injection and are monitored for about a week in a clinic, with follow-up visits up to 29 days. The goal is…

This study looks at how beta-cells (which make insulin) respond to growth hormone in women who had gestational diabetes. Researchers want to understand why some women develop high blood sugar during pregnancy. The study involves 30 women and uses tests to measure insulin producti…

This study tests whether stimulating the vagus nerve with a small device placed behind the ear can affect insulin, C-peptide, and blood sugar levels. Researchers will measure these changes in 30 healthy adults aged 18-70. The goal is to learn how the vagus nerve controls insulin,…

This early-stage study is testing a new antibiotic called BAL2420 in healthy adults to see if it is safe and how the body processes it. The drug is being developed to fight serious bacterial infections that are hard to treat. About 136 volunteers will receive either the drug or a…

This study tests whether a temporary, non-invasive brain stimulation technique called TMS can change how healthy people respond to stress. About 55 participants will complete tasks during MRI scans, then receive both real and sham TMS on different days to compare effects. The goa…

This study looks at whether intermittent fasting helps healthy adults lose body fat and improve their quality of life. Researchers will measure body fat percentage and visceral fat in 70 participants. The goal is to see if this eating pattern is a practical way to manage weight.

This early-stage study tests a new drug called LY4088044 in healthy adults to see if it is safe and how the body handles it. About 104 participants will receive the drug or a placebo, either as a shot under the skin or into a vein. The study lasts up to 92 weeks and focuses on si…

This study looks at how a new drug, MK-2828, interacts with two other medicines in healthy adults. In one part, participants take MK-2828 with itraconazole to see if levels change. In another part, they take MK-2828 multiple times before a single dose of midazolam. The goal is to…

This study tests whether healthy adults can learn to control a part of their brain linked to worry using real-time brain scans (fMRI). Sixty participants will receive either real or fake feedback as they try to reduce their anxiety about upcoming events. The goal is to see if thi…

This study looks at whether breathing slowly (6 breaths per minute) lowers stress more than breathing at a normal pace or just sitting still. Healthy adults will practice a breathing method, then take a stress test involving cold water and math. Researchers will measure heart rat…

This study follows 120 college freshmen for one year to see how vegan, vegetarian, or omnivore diets affect body weight, fat, and the bacteria in their gut and mouth. Participants provide saliva, stool, urine, and blood samples to track changes. The goal is to understand how diff…

This study follows 10,000 healthy adults for up to 20 years to find ways to detect cancer earlier. Participants give blood samples and answer questionnaires about lifestyle and medications. The goal is to identify changes in proteins, RNA, and DNA that signal cancer before sympto…

This study looks at how genetic differences affect the way healthy adults process the blood thinner warfarin. Researchers will give participants single doses of warfarin and other drugs to measure metabolism and compare it to their DNA. The goal is to better understand why warfar…

This study looks at tongue strength and endurance in 300 healthy adults aged 18 and older. Using a special device, researchers will measure how well participants can push and lift their tongues. The goal is to understand normal tongue function and see how it relates to handgrip a…

This study looks at how small changes in your genes might affect the body's natural ability to control inflammation. Inflammation is a normal response to injury or illness, but when it goes unchecked, it can lead to diseases like rheumatoid arthritis and heart problems. Researche…

This study tests two different injector pens that deliver the same medicine (Genotropin) under the skin. Researchers want to see if both pens work the same way in healthy adults aged 18 to 60. Participants will receive one dose with each pen and have blood samples taken to measur…

This study looks at how blind people use a white cane not just to move around, but to sense the world. Researchers will measure where people feel a touch on the cane and track brain activity with EEG and MRI. The goal is to understand how the cane becomes an extension of the body…

This study looks at how different parts of the brain talk to each other in healthy adults. Researchers will use safe, non-invasive methods like magnetic stimulation and brain wave recordings to measure these connections. The goal is to better understand normal brain function, not…

This study looks at whether adding polyphenol-rich foods like beans and lentils to your daily diet can improve skin health. Researchers will study 50 women aged 45-65 over 12 weeks, measuring skin redness, moisture, and other factors. The goal is to see if these foods change the …

This study aims to see if special force sensors can reliably measure how tight a carbon-fiber leg brace (ankle-foot orthosis) presses against the leg. Researchers will test 60 people: healthy volunteers, regular brace users without nerve damage, and regular brace users with perip…

This early-stage study is testing whether an inhaled drug called RB042 is safe and how the body processes it. About 90 healthy adults and healthy smokers will receive either the drug or a placebo. The goal is to check for side effects and measure drug levels in the body, not to t…

This early-stage study is testing a new drug, SRK-439, in 76 healthy adults aged 18 to 55. The goal is to check if the drug is safe and how the body processes it. Participants will receive either one or multiple doses of the drug or a placebo. This study does not aim to treat any…

This study aims to measure how much energy healthy Chinese people use each day using a precise method called doubly labelled water. Researchers will collect data from 240 healthy children and adults across China, along with body measurements, blood tests, and activity levels. The…

This study looks at how much protein male cyclists aged 65 and older need after a cycling workout. Researchers will use a safe, non-invasive method to measure protein requirements. The goal is to improve dietary guidelines for active older adults. Eight healthy, experienced cycli…

This study looks at a part of the brain called the reticulospinal system, which helps control movement like walking and reaching. Researchers will use loud sounds and motion tracking to measure how this system works in healthy people and in those with spinal cord injuries. The go…

This study is testing whether a supplement called 7-keto lithocholic acid (7-KLCA) can change the types of bacteria living in the gut and improve health markers like blood sugar and cholesterol. Researchers will give the supplement to 40 healthy adults for 12 weeks and measure ch…

This study tests whether brain stimulation can help healthy adults quickly reach a deep meditative state, normally achieved only after years of training. Twelve participants will wear a special cap, receive brain stimulation, and perform meditation tasks while researchers measure…

This early-stage study is testing a new drug called BI 3031185 in 60 healthy men aged 18 to 50. The goal is to see if the drug is safe and how the body processes it when taken by mouth multiple times. Participants will be randomly assigned to receive either the drug or a placebo,…

This study looks at whether a diet low in methionine (an amino acid) can change the bacteria in your gut and lower inflammation. Forty healthy adults will follow the diet for several weeks, with some also taking methionine supplements or a placebo. Researchers will measure gut ba…

This study looks at whether eating dinner earlier in the day can improve how the body burns fat and handles blood sugar. Researchers will compare early versus late dinner in 32 adults, including healthy-weight individuals and those with obesity and prediabetes. The goal is to und…

This study aims to learn more about the natural bacteria (microbiome) living in the vagina and mouth of healthy women. Researchers will collect swab samples from 520 participants visiting gynecology or dermatology clinics in Finland. No treatments or medications are involved—only…

This study aims to develop a simple decision tool for physical therapists to know when they should check vital signs like heart rate and blood pressure during outpatient therapy. Researchers will survey 100 experienced physical therapists over three rounds to agree on which signs…

This study looks at whether listening to music while running changes the forces your feet apply to the treadmill and your overall running form. Researchers will measure things like impact and how your body moves. The goal is to understand if music can affect injury risk or perfor…

This study will measure how fast 360 healthy young people (ages 6-20) need to walk to get health benefits. Researchers will track steps per minute and heart rate to create simple, personalized walking guidelines. The goal is to replace vague advice like 'walk briskly' with clear …

This study looks at how physical fitness changes the bacteria in your gut. Researchers will compare gut microbes from inactive people to elite athletes to see if exercise boosts gut health. The goal is to understand which bacteria are linked to better fitness and create a sample …

This study aims to improve how we see inflammation in the brains of people with Alzheimer's disease. Current scans can't tell which brain cells are inflamed, but this new method uses two different tracers and math to separately track microglia and astrocytes. Researchers will sca…

This study aims to find the best way to record electrical signals from the stomach using a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS). Researchers will test different stimulation settings and locations in healthy adults to see what tri…