Can a Plant-Based diet tame inflammation by reshaping gut bacteria?

NCT ID NCT07283328

Recruiting now Knowledge-focused Sponsor: Centre hospitalier de l'Université de Montréal (CHUM) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a low-methionine diet can change the gut microbiome and reduce inflammation in 40 healthy adults. Participants follow a plant-based, low-methionine diet for several weeks, with some also taking methionine supplements or a placebo. Researchers will measure gut bacteria, blood markers, and immune cells to see if the diet shifts the body toward an anti-inflammatory state. The goal is to gather knowledge that could eventually help design dietary strategies for multiple sclerosis.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: methionine-restricted diet
What this could lead to: If successful, this could point toward a dietary approach to reduce inflammation that might help manage multiple sclerosis.
What could go wrong: This is a small, early pilot study in healthy people, not patients. Results may not apply to those with MS, and the diet is restrictive, which could affect adherence.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Inflammation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY

Contacts and locations

Locations

Centre de recherche du Centre Hospitalier de l'Université de Montréal
RECRUITING

Montreal, Quebec, H2X 0A9, Canada

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