HEALTHY

This phase 2 trial tested a drug called ciraparantag to see if it could quickly reverse the effects of blood thinners in 41 healthy adults. Participants received either ciraparantag or a placebo, and their blood clotting time was measured. The study was terminated early, so the f…

This early-stage trial tested the safety and tolerability of a new medicine called REM0045392, being developed for Alzheimer's disease. The study involved 19 healthy adults, including younger men and older men and women, who received either the drug or a placebo. The trial was te…

This study tested whether a silver nanoparticle gel (SilvaSorb®) could kill bacteria on hands better than a common alcohol-based hand gel (Purell). Healthy volunteers had their hands seeded with a harmless bacteria, then used one of the gels. The trial was terminated early and on…

This study tested a new cooling device to manage pain during radio-frequency microneedling, a cosmetic skin treatment. It involved 6 healthy women and measured pain levels after different cooling times. The study was terminated early, so results are limited.

This small pilot study tested whether a cream containing stem cell secretions and licorice root extract could safely improve vaginal laxity (looseness) in women. 18 Malaysian women aged 40-55 used the product for 5 weeks. Researchers measured changes using a questionnaire and a d…

This early-stage trial aimed to check the safety and how the body handles a new drug called BI 3731579. It involved 30 healthy adults who took multiple doses over 15 days. The study was terminated early, and no results are available. Since it only tested safety in healthy people,…

This early-stage study aimed to compare how a tablet form of tafamidis is absorbed in the body compared to the existing capsule form. It involved 24 healthy adults who took a single dose of each form under fed conditions. The study was terminated early, so results may be limited.

This study looked at why exercise training improves blood vessel function less in some people with COPD than in healthy individuals. Researchers measured blood vessel health before and after a 4-week exercise program in 69 participants, including COPD patients and healthy volunte…

This early-stage trial tested the safety and how the body processes a single dose of the experimental drug BI 1569912 in 68 healthy men. The study also looked at how food affects drug absorption. The trial was terminated, so results are limited.

This Stanford study looked at how changing when and what you eat affects blood sugar, body temperature, and sleep in people with prediabetes, type 2 diabetes, and healthy adults. Participants followed different meal-timing schedules, like eating within a 10-hour window starting e…

This early-phase study aimed to measure how a standardized ashwagandha supplement is absorbed and tolerated in healthy adults aged 65 and older. Eleven participants took either 240 or 480 mg of the supplement, and researchers tracked levels of active compounds in the blood over 4…

This early-stage trial tested the safety and how the body handles a new drug called BI 3009947 in 40 healthy men. The study was terminated early. It was not designed to treat any disease, but to gather basic information about the drug's safety and processing in the body.

This study looks at how healthy men absorb, break down, and eliminate the experimental drug BI 1819479. It involves taking the drug by mouth and, in one part, receiving a tiny radioactive tracer through a vein. The goal is purely to gather information, not to treat any disease. T…

This study looked at how trail running and marathon running affect fatigue and recovery. Healthy runners completed a simulated marathon, a simulated trail run, or a real trail run. Researchers measured muscle strength before, right after, and one month after each race to see how …

This study aimed to compare how the immune system responds to two different seasonal flu vaccines given at the same time. Healthy adults aged 18-49 who had not received a flu shot in at least three years were eligible. The study was terminated early and only enrolled 2 participan…

This early-stage study aimed to see how two common malaria drugs, artemether-lumefantrine and amodiaquine, interact in the body. It enrolled only 8 healthy adults in Thailand and was terminated early. The goal was to measure drug levels and safety when given alone or together.

This early-phase study tested the safety and how the body handles a new drug called MT-6345 in 52 healthy adults. Participants received either the drug or a placebo, and researchers monitored for side effects and drug levels in the blood. The study was terminated early, so result…

This study aimed to see if a mind-body medicine training program could help parole staff feel less stressed and more resilient. The program taught techniques like meditation, breathing exercises, and guided imagery. The study was terminated early and only 27 people took part, so …

This early-stage study aimed to check the safety and how the body processes a new experimental drug (PF-07899895) in healthy adults aged 18-65. Participants received either the drug or a placebo in different dosing schedules. The study was terminated early, so no results are avai…

This early study aimed to see if insulin given as a nasal spray reaches the brain and spinal fluid. Only 2 healthy adults were enrolled before the study was stopped. Researchers planned to measure insulin levels in spinal fluid and blood at several time points after a single dose…

This early-stage study tested the safety and side effects of an experimental drug called LY3463251 in healthy and overweight adults. Participants received either the drug or a placebo as a single or multiple injection under the skin. The study was stopped early, and it was not de…

This early-stage study tested an experimental drug called PF-07314470 in 23 healthy adults to see if it was safe and how the body processes it. Participants received either the drug or a placebo by injection under the skin. The study was terminated early, so results are limited.

This early-phase study aimed to test the safety of a new drug called LY3872386 in healthy volunteers and people with atopic dermatitis (eczema). The trial was terminated early, so no meaningful data on safety or how the body processes the drug were collected. Only 18 participants…

This study tested a new, taste-masked powder form of the antibiotic delafloxacin to see if the body absorbs it as well as the current tablet. It involved 16 healthy adults who took both versions. The goal was to make the medicine easier to take, especially for people who have tro…

This early-stage trial tested the safety and how the body processes a new drug called BI 706321 in healthy Japanese and Chinese men. The study was terminated early, so no results are available. It was designed to check for side effects and measure drug levels in the blood.

This early-stage trial in 8 healthy men aims to understand how the experimental drug BI 1839100 is processed by the body. Part A tracks the drug and its radioactive label in urine and feces after an oral dose. Part B compares how much of the drug reaches the bloodstream when give…

This Phase 1 study tested the safety and side effects of an experimental drug called LY3526318 in 76 healthy volunteers. The drug was given by mouth, and participants were monitored for up to 51 days. The trial was terminated early, so results may be limited.

This study looked at whether a single IV dose of oxytocin, a natural hormone, could reduce pain from heat on the skin. It included 7 people — some healthy and some with severe knee arthritis. Researchers measured pain scores during a 5-minute heat test. The study was terminated e…

This study looked at how two different exercise programs—moderate and high intensity—affect the way the brain processes pain in healthy, sedentary adults. Researchers measured pain sensitivity and the body's natural pain modulation systems before and after a 10-week training peri…

This pilot study tested a new MRI technique that uses inhaled xenon gas instead of X-rays to create images of the lungs and brain. Forty healthy adults aged 18 to 75 took part. The goal was to see if this method produces clear images without radiation. The study was terminated ea…