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Insulin nasal spray: can it reach the brain?

NCT ID NCT05866367

Terminated Knowledge-focused Sponsor: HealthPartners Institute Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This early study aimed to see if insulin given as a nasal spray reaches the brain and spinal fluid. Only 2 healthy adults were enrolled before the study was stopped. Researchers planned to measure insulin levels in spinal fluid and blood at several time points after a single dose.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Regular insulin (Novolin-R) given as a nasal spray
What this could lead to
If successful, this could show that insulin nasal spray reaches the brain, supporting future research into memory and mood treatments.
What could go wrong
This was a very small, early-phase study that was terminated before completion. Results may not be reliable or generalizable.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY

Contacts and locations

Locations

  • HealthPartners Neuroscience Center

    Saint Paul, Minnesota, 55130, United States

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