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Can a new oral drug safely help older adults manage weight?

NCT ID NCT07085468

NEW Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 21, 2026 · Last updated Sep 21, 2026

Summary

Researchers are testing an experimental oral drug called LY3549492 in adults aged 55 to 80 who have a healthy body mass index. The main goal is to see how safe and tolerable the drug is compared with a placebo. Participants take the drug or placebo for about 13 months, and researchers track serious side effects and changes in body weight.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
an experimental oral drug called LY3549492
What this could lead to
If it works, this could point toward a new oral treatment for weight management in older adults.
What could go wrong
This is an early-stage safety study with very few participants, so it may not show whether the drug works or how it compares with existing options. Side effects could also limit its use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

1 person

The number who actually took part.

Started

Jul 2025

Finished

Aug 2025

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

55 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Have a body mass index (BMI) within the range of 22 to 25 kilograms per square meter (kg/m2) * Have had a stable body weight for 3 months prior to screening Exclusion Criteria: * Have type 1 diabetes, latent autoimmune diabetes in adults, or a history of ketoacidosis or hyperosmolar coma * Have: * type 2 diabetes and on antidiabetic therapy (except type 2 diabetes being managed with diet and/or stable dose of metformin) * rare forms of diabetes mellitus, or * hemoglobin A1c (HbA1c) \>8% * Have poorly controlled hypertension * Have any of the following cardiovascular conditions within 12 months prior to screening: * acute myocardial infarction * stroke * unstable angina, or * hospitalization due to congestive heart failure. * Have a history of New York Heart Association Functional Classification III or IV congestive heart failure * Have signs and symptoms of liver disease * Have a history of pancreatitis * Have taken medications or alternative remedies for weight loss or weight gain within 3 months prior to screening

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Conditions

The condition(s) this trial relates to.

Body Weight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy

Contacts and locations

Locations

  • Alliance for Multispecialty Research, LLC

    Lexington, Kentucky, 40509, United States

  • Alliance for Multispecialty Research, LLC

    Norman, Oklahoma, 73069, United States

  • Apex Trials

    Guelph, N1G 0B4, Canada

  • Artemis Institute for Clinical Research

    San Diego, California, 92103, United States

  • BioPharma Services

    Toronto, M9L 3A2, Canada

  • Clinical Research Atlanta

    Stockbridge, Georgia, 30281, United States

  • Clinique Mémoire de Montréal

    Montreal, H3G 1H9, Canada

  • Diex Recherche Trois-Rivieres

    Trois-Rivières, G9A 4P3, Canada

  • Great Lakes Clinical Trials - Andersonville

    Chicago, Illinois, 60640, United States

  • Headlands Research - Scottsdale

    Scottsdale, Arizona, 85260, United States

  • JEM Research Institute

    Atlantis, Florida, 33462, United States

  • OCT Research ULC

    Kelowna, V1Y 1Z9, Canada

  • Ottawa Memory Clinic

    Ottawa, K1Z 1G3, Canada

  • Peninsula Research Associates

    Rolling Hills Estates, California, 90274, United States

  • Q&T Research Sherbrooke Inc.

    Sherbrooke, J1J 2G2, Canada

  • Richmond Clinical Trials

    Richmond, V6V 2L1, Canada

  • Toronto Memory Program

    Toronto, M3B 2S7, Canada

  • Trial Management Associates

    Myrtle Beach, South Carolina, 29572, United States

  • Valley Clinical Trials, Inc.

    Covina, California, 91723, United States

  • Valley Clinical Trials, Inc.

    Northridge, California, 91325, United States

  • Viacar Recherche Clinique

    Greenfield Park, J4V 2G8, Canada

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