HEALTHY

This study tests an experimental vaccine called V132 in healthy adults aged 50 and older. The goal is to see how safe it is and how well it triggers an immune response compared to existing pneumococcal vaccines. Participants will receive one of several formulations of V132 or a c…

This phase 2 trial tests V540A, an experimental vaccine designed to protect against 9 HPV types already covered by Gardasil 9, plus additional unique types. About 525 healthy women aged 16-26 will receive either V540A or Gardasil 9 to compare safety and immune response. The goal …

This early-stage trial is testing different pill versions of an experimental drug called MK-4082, which is being developed as a potential weight-loss treatment. The study will enroll about 48 healthy adults who are overweight or obese to see how well the body absorbs each version…

This study tests whether a workplace program that teaches employees and managers about pain and how to communicate about it can reduce pain-related sick leave. The program includes a digital education session and a workplace needs assessment. Researchers will track sick days, pai…

This study tests whether a daily vitamin C supplement called Qualia Vitamin C+ can raise blood vitamin C levels in healthy adults aged 25 to 75 who have either low or normal vitamin C levels. Participants take two capsules daily for 28 days and provide blood samples to measure ch…

This study tests a drug called mirikizumab, which is already approved for other conditions, in people with schizophrenia who have a specific immune marker (AGA IgG antibodies). The goal is to see if it can improve negative symptoms like lack of motivation and pleasure, as well as…

This study tests a new, non-invasive method to detect colorectal cancer and precancerous growths by analyzing odors from breath and intestinal gas. About 453 participants—including people with colorectal cancer, precancerous lesions, and healthy volunteers—will provide samples an…

This study tests a non-invasive light-based device (SR-NIRS) to measure blood flow and oxygen in the testicles of children. It includes 74 boys aged 1 month to 18 years, both healthy and those with sudden scrotal pain. The goal is to see if this device can help tell if testicular…

This study will test a new portable device called the Cobra Ankle Arthrometer to see if it can accurately measure ankle joint looseness. Researchers will compare it to ultrasound imaging in 62 young adults, including those with chronic ankle instability, previous sprains, or no a…

This trial tests whether a magnesium-based supplement taken before bed can improve sleep quality and speed up recovery after intense exercise. Healthy, recreationally active adults aged 18-40 will take the supplement or a placebo for two weeks each, then complete a leg exercise p…

This study tests whether a special probiotic (a type of good bacteria) can help healthy adults sleep better and feel less stressed during short trips. Researchers will give 60 volunteers either the probiotic or a placebo and track their sleep, stress, and gut health. The goal is …

This study tests whether a combination of essential oils—taken as a capsule and applied to the skin—can improve digestive health and overall well-being. Healthy adults aged 18–45 will use the oils daily for four weeks, while researchers measure changes in gut symptoms, blood mark…

This study will test a combined tooth-whitening procedure on 10 healthy adults to see how the green-red color axis (called a*) contributes to overall whiteness. Participants will first get in-office bleaching with 40% hydrogen peroxide, then use a 16% carbamide peroxide gel at ho…

This study looks at whether a broccoli-derived compound called glucoraphanin can help muscles recover from exercise-induced damage. Seventeen healthy adults will take broccoli powder or a placebo for a week before doing muscle-damaging arm exercises. Researchers will measure stre…

This study tests whether a special vibration device can reduce pain and anxiety in children aged 6 to 14 during dental injections. Each child will receive both the device and a manual vibration method on separate visits to compare the effects. The goal is to make dental visits mo…

This study tests Prosman™, a supplement made from plum extract, in 38 men aged 40-60 with mild to moderate prostate enlargement symptoms. Participants will take either Prosman™ or a placebo daily for 8 weeks. Researchers will measure changes in urinary symptoms, hormone levels, a…

This early-stage trial is testing an investigational drug called LY4355756 in healthy volunteers to see how safe it is and how the body absorbs it. Participants will receive the drug as an oral capsule or tablet, with some also receiving midazolam to check for drug interactions. …

This study tests whether a new device called Blood'up can help locate the radial artery in the wrist better than the traditional method of feeling for the pulse. Healthy volunteers will have arterial blood samples taken from both wrists, one using the device and the other using m…

This Phase 1 trial is testing whether an experimental drug called verducatib affects the heart's electrical activity, specifically the QT interval, which is a measure of heart rhythm safety. Healthy adults aged 18 to 50 will receive multiple doses of verducatib, a placebo, or mox…

This study looks at how beta-cells (which make insulin) respond to growth hormone in people with prediabetes. Researchers will measure insulin release in 10 adults with impaired fasting glucose or impaired glucose tolerance. The goal is to better understand what raises the risk o…

This trial investigates whether taking lithium for a week changes how the eyes and brain respond to light in healthy adults aged 18 to 40. Participants will undergo light exposure sessions with and without lithium, while researchers measure melatonin suppression, alertness, mood,…

This early-stage trial aims to see if a single injection of ART105 is safe and tolerable in healthy adults aged 18 to 55. It also looks at how the drug moves through the body and whether it changes urine PC1 levels. Participants receive one dose and are followed for about three m…

This study explores how a special mat with sensory bumps can change brain activity in people with chronic low back pain. Researchers will scan the brains of 20 patients and 20 healthy volunteers while they lie on the mat. The goal is to see if the mat can help restore the brain's…

This early-stage trial is testing an investigational drug called MK-1406 in healthy adults. The goal is to compare what happens to the drug in the body when it's given as two injections versus three injections, and to check if it's safe and well-tolerated. Participants will recei…

This trial tests whether an AI-assisted documentation tool (an 'AI scribe') can help nurses by reducing time spent on record-keeping. About 400 nurses from child and student health services in a Finnish region will adopt the tool at different times, allowing comparison between ea…

This early-stage trial is testing whether an experimental drug called HW243040 is safe and tolerable in healthy adults aged 18 to 55. Participants receive either the drug or a placebo, and researchers monitor for side effects and how the drug moves through the body. The goal is t…

This study examines how the body processes nemtabrutinib in people with severe kidney impairment compared to healthy volunteers. By measuring drug levels in the blood after a single dose, researchers aim to understand whether kidney function changes how the drug is handled. The r…

This trial investigates whether pramipexole tablets produced at two different manufacturing sites are processed identically by the body. Healthy volunteers aged 18 to 55 take both versions in a crossover design, and researchers compare drug levels in the blood. The goal is to con…

This study investigates how pomegranate dietary supplements influence gut bacteria and inflammation in people with alcohol use disorder and alcohol-related liver disease. Researchers will measure levels of beneficial gut metabolites called urolithins and inflammatory markers in b…

This study looks at whether different types of exercise—like high-intensity workouts and Tai Chi—can improve thinking skills and lower stress in first-year university students. About 120 healthy students aged 18-25 will take part in a 12-week program. Researchers will compare the…

This early-stage trial is testing how an experimental drug called PF-08653945 enters the bloodstream when injected into different areas of the body. Researchers will give a single dose to adults who are overweight or obese and measure drug levels in the blood over time. The goal …

This study tests short videos that explain epigenetics — how things like pollution and exercise can turn genes on or off. Researchers want to see if these videos help people understand the science without increasing stigma or blame. About 1,000 English-speaking adults from differ…

This study explores how to communicate about epigenetics — the process by which environment and lifestyle can turn genes on or off — in a way that is understandable and does not create ethical or social problems. Researchers will show different videos about epigenetics to 1,000 h…

This study tests whether a smartphone app that uses artificial intelligence to send gentle reminders can help young adults (ages 18–24) who struggle with food insecurity make better food choices. About 114 UC Davis students will use either a basic app that tracks what they eat or…

This early-phase study tests an experimental oral drug called LY4268989 (MORF-057) in 50 healthy adults. Researchers want to see if two different tablet forms are processed similarly by the body, and how meals affect that process. Participants will stay at a research unit for 18 …

This early-phase trial investigates how healthy male volunteers process and eliminate a single dose of the experimental drug BI 3034701. Eight men with normal weight or overweight will receive the drug mixed with a tiny amount of radioactive tracer, allowing researchers to track …

This study tests a prototype device that measures electrolytes like sodium and potassium in urine. Healthy adults aged 18 to 60 will provide urine samples after eating different standardized meals (such as high-fruit or nut diets) and during their normal daily life. The goal is t…

This study investigates how two types of plyometric training—body-weight jumps versus jumps with a weighted vest—affect athletic performance in young female soccer players. Thirty-six participants will be split into three groups: body-weight plyometrics, loaded plyometrics, or ro…

This study investigates how different levels of oxygen and carbon dioxide in the blood affect the strength and function of the diaphragm and leg muscles, both at rest and during exercise. Sixteen healthy, non-smoking adults will breathe various gas mixtures—including low oxygen (…

This study aims to build a registry of healthy adults aged 18 and older who have been prescreened for future research at the National Institute of Neurological Disorders and Stroke (NINDS). Volunteers undergo a single visit lasting about 5 hours, which includes a physical exam, n…

This study investigates how the experimental drug AZD4144 behaves in the body when taken alone and with itraconazole, a common antifungal. Healthy adults aged 18-55 with a BMI between 18 and 30 are eligible. The goal is to measure drug levels and clearance, helping to guide futur…

This study tests whether a smartphone app can help parents teach their 3- to 5-year-olds basic motor skills like jumping and balancing. Over 12 weeks, families follow short daily activity breaks guided by the app. Researchers will check if these physical skills also boost childre…

This early-stage trial studies how different tablet forms of MK-1403, a drug designed for heart and blood vessel disease, are absorbed and tolerated in healthy adults. Researchers will measure the drug levels in the blood and monitor for any side effects. The results will help de…

This study tests three different electrical stimulation foot pad programs in 24 healthy adults to see which one improves blood flow in the legs the most. Participants will use each program once for 30 minutes while blood flow and muscle oxygen are measured. The goal is to find ou…

This study looks at whether exercise can help protect the body from health problems caused by shift work, which disrupts natural sleep-wake cycles. Sixteen healthy but inactive adults will spend 5 days in a lab, simulating day shifts then night shifts, with some doing exercise. R…

This early-stage study looks at whether a single dose of ulonivirine changes how the body processes methadone. Fourteen healthy adults who are already on a stable methadone program will take methadone alone and then with ulonivirine. The goal is to measure drug levels in the bloo…

This observational study will follow 200 women aged 45 to 60 to understand how muscle strength, bone density, body composition, physical activity, sleep, mood, and menopause symptoms relate to overall functional health. Participants will undergo simple strength tests, bone scans,…

This early-stage study tests whether low-intensity focused ultrasound can temporarily change how healthy adults perceive pleasant or unpleasant smells. Twenty-eight volunteers will receive both real and sham ultrasound targeting brain areas linked to smell and emotion. The goal i…

This study explores whether non-invasive vagus nerve stimulation — either with a mild electrical pulse on the ear or through manual massage techniques — can change heart rate variability and ease symptoms like fatigue and poor sleep. Researchers will compare two approaches in hea…

This study will look at how well prilocaine works as a spinal anesthetic for people having knee arthroscopy as outpatients. Researchers will measure how fast sensation and movement return, how soon patients can walk and go home, and how often side effects like nausea or trouble u…

This study looks at whether giving Asian college students personalized information about their alcohol metabolism and genetic risks can influence their drinking habits. Researchers will follow 450 USC students of Chinese, Japanese, Korean, or Vietnamese heritage for two years. Pa…

This study will give 48 healthy adults either psilocybin (the active ingredient in magic mushrooms) or a placebo, then test their memory with picture tasks and scan their brains with MRI. The goal is to see how psilocybin changes memory accuracy and brain activity. It is not a tr…

This study will measure leg and handgrip strength in about 2,800 healthy adults and people with chronic lung diseases across Spain, Portugal, and Italy. Researchers want to create normal muscle strength values for these populations and see if the same standards can apply to peopl…

This study looks at how two types of non-invasive brain stimulation affect brain activity, and whether using them together works better than alone. The goal is to understand why brain stimulation for depression is less effective in women after menopause, possibly due to lower est…

This study compares a new tool called the TOngue Manometer (TOM) with the current standard device (IOPI) for measuring tongue muscle function. Researchers will test 58 healthy adults aged 18 to 65 to see if the TOM gives more accurate results. The goal is to improve how tongue st…

This early-stage study tests a new drug, HS-20136-2, in 38 healthy adults to see if it is safe and how the body handles it. Participants receive a single injection of either the drug or a placebo, and researchers monitor for side effects and measure drug levels in the blood. Sinc…

This study looks at how whole-body heat therapy (hyperthermia) changes body temperature, pain sensitivity, and pain during movement in 60 people—half with chronic widespread pain (like fibromyalgia) and half healthy. Participants will receive six heat sessions over three weeks. T…

This study will observe how healthy lungs work by using two non-invasive tests: a special MRI that shows lung ventilation and a breathing test that measures airway resistance. Twenty healthy adults will participate to help researchers understand the relationship between these mea…

This early-phase study tests whether taking a low-dose aspirin in the evening can offset the blood pressure increases caused by the pain reliever celecoxib. Researchers will monitor blood pressure in 60 healthy adults over several weeks. The goal is to learn if timing matters for…

This early-stage trial will test the safety of a single dose of SSS68 in 50 healthy adults aged 18-45. Participants will receive either the drug or a placebo, and researchers will monitor for side effects and how the drug moves through the body. The study is not yet recruiting an…

This study will use focused ultrasound to stimulate the part of the brain that controls movement. Researchers will measure changes in brain signals and chemical levels in 25 healthy adults. The goal is to understand how ultrasound affects brain activity, which could guide future …

This study looks at whether the natural daily rise and fall of cortisol in the blood is also seen in the fluid surrounding eggs in the ovary. Researchers will collect blood and follicular fluid samples from 20 women undergoing IVF, either at 8 a.m. or 8 p.m. The goal is to better…

This study looks at whether playing alternative sports (korfball, flag football, kin-ball, ultimate frisbee) during physical education classes can improve motor skills, fitness, and enjoyment in 210 healthy primary school students. Over 8 weeks, one group will play these sports w…

This study looks at how a non-invasive brain stimulation technique called rTMS affects two different areas of the cerebellum in 40 healthy adults. One area is linked to movement, the other to thinking and attention. By comparing the effects, researchers hope to learn which brain …

This study tests a new AI chatbot designed to help parents recognize and resist false information about childhood vaccines. About 5,000 parents from five European countries will use the chatbot or read standard health materials, then take a quiz to see how well they can tell true…

This study explores whether cognitive flexibility—the ability to switch between different ways of thinking—can be improved through targeted training. Researchers will enroll 225 healthy adults aged 18-29 and have them complete up to 12 sessions of structure learning or set-shifti…

This study looks at how eating chickpeas in different forms—whole, pureed (like hummus), or as flour (like pasta)—affects how the body uses energy. Researchers will measure fat, carbohydrate, and protein burning in 204 healthy adults over 12 weeks. The goal is to understand if pr…

This study looks at whether a single session of seated Tai Chi, played like a video game, can improve memory and thinking in healthy adults aged 18-30 and 60-75. Participants will try both the Tai Chi game and simple seated stretching on different days. Brain activity will be mea…

This study looks at whether teaching nursing students to use AI for case analysis helps them think more critically. About 400 students will be split into two groups: one gets AI-based training, the other gets traditional teaching. The goal is to see if the AI group improves their…

This study looks at a new idea called 'satiety per calorie' (SPC) — how full a food makes you feel for each calorie it contains. Researchers will give 40 healthy men different foods and measure how much they eat. The goal is to see if foods with higher SPC help people eat less wi…

This early-stage trial in 28 healthy adults tests whether eating a meal changes how the body absorbs a single tablet containing three diabetes medicines (gemigliptin, dapagliflozin, and metformin). Participants take the pill once while fasting and once after a meal, and researche…

This study looks at how to accurately measure muscle strength in 112 healthy women. Researchers compare two methods of adjusting strength results for body size. The goal is to find which method gives more consistent results, helping future studies and treatments.

This study looks at whether showing people a live video of their swallowing pressure helps them perform swallowing exercises better. Fifty healthy adults aged 18-40 will swallow with a thin pressure-sensing tube in their nose. Researchers will compare swallowing strength and timi…

This study looks at how different liquid versions of the drug osivelotor taste and how well they get into the blood compared to a tablet. It also checks if taking the drug with food or an antacid changes absorption. About 52 healthy adults aged 18 to 65 will take part.

This study looks at whether using artificial intelligence in case discussions can help midwifery students become more comfortable and skilled with AI tools. Researchers will compare students who review AI-assisted care plans with those who don't. The goal is to see if this approa…

This study tests whether a conversational AI chatbot can help parents and caregivers in the UK better identify false information about childhood vaccines. Around 1000 participants will be randomly assigned to either interact with the chatbot or view a standard social media infogr…

This is an early-stage study testing a new drug, SSS67, in 52 healthy adults. The main goal is to see if it is safe and how the body handles it. Participants receive a single dose of SSS67 or a placebo by IV. The study also looks at how the drug affects bone markers and metabolis…

This study compares two types of brain stimulation—electrical and magnetic—to see which one better improves working memory. 102 healthy adults will perform memory tasks while receiving stimulation, and their brain activity will be recorded with EEG. The goal is to find out if mag…

This early-stage study tests a new drug called PF-08065010 in 100 healthy adults aged 18 to 65. The goal is to check its safety and how the body processes it, as a first step toward possibly treating rheumatoid arthritis and lupus. Participants receive either the drug or a placeb…

This study investigates if healthy young adults who usually drink little plain water feel thirstier after increasing their water intake for four weeks. Participants will drink about 2 liters of water daily to dilute their urine. The goal is to understand if the body adapts to chr…

This study aims to find the best way to collect and handle stool samples for gut bacteria (microbiota) research. Researchers will compare different collection methods to the standard quick-freeze technique. Ten healthy adults aged 18 to 85 will provide samples. The goal is to imp…

This study looks at inflammation inside the tooth's inner tissue (dental pulp) in people with painful pulpitis compared to healthy individuals. Researchers will measure specific inflammation markers in saliva, gum fluid, and pulp tissue to see if they reflect the level of inflamm…

This study will test a new device that uses a camera and machine learning to measure foot pressure and foot area. Researchers will compare it to the current standard pressure mat in 150 healthy adults. The goal is to see if the new tool is accurate and reliable enough for future …

This study will test a new ultrasound device that creates 4D images of the upper airway in real time. Researchers will scan the neck and jaw area of 100 healthy adults to measure airway size. The goal is to see if this technology can overcome current limits, like imaging behind b…

This study checks if a special camera that looks at tiny blood vessels under the tongue can give consistent results. Researchers will measure 200 people—healthy volunteers and ICU patients—multiple times to see if the method is reliable. The goal is to improve how doctors monitor…

This study looks at how a national program providing free school meals affects the health, well-being, and learning of Danish children aged 10 to 15. Over 3,200 kids from schools offering free meals will be compared to those without. Researchers will track changes in quality of l…

This study looks at whether a regular video camera can track how movement changes when healthy people do large exercises like reaching or stepping. About 26 volunteers will perform six exercises while being recorded. The goal is to see if the camera can spot when movements get sm…

This study will test how a new nano-curcumin supplement is absorbed by the body compared to a standard curcumin product. Twelve healthy adults will take both types of capsules at different times, and their blood will be checked for curcumin levels. The goal is simply to measure a…

This early-stage study looks at how a single dose of a probiotic supplement changes gene activity and sugar patterns in the small intestine of 8 healthy adults. Participants will take the probiotic alone, with fiber, or a placebo, then have a small tissue sample taken the next mo…

This early-stage trial will enroll 60 healthy adults to compare two drug formulations: an orally disintegrating tablet (HIP2503) and a standard tablet (HCP1306). The goal is to see how each is absorbed and processed by the body, and to check for safety. Participants will take a s…

This pilot study will test a new type of eye scanner called polarization-sensitive OCT in 20 healthy adults. The device takes detailed images of the retina's nerve fiber layer to measure its structure. Researchers want to see if this technology can provide clearer images than cur…

This study tests whether placebo suggestions work better when they match a person's natural motivational style—either focusing on promoting good feelings or preventing pain. Sixty healthy adults will receive a plain hand cream but be told it's a pain reliever, with suggestions ta…

This study investigates how two molecules—glycerol from fat and lactate from the blood—are converted into glucose by the liver, especially in people with type 2 diabetes. Researchers will compare these processes in 48 adults with and without diabetes or obesity. Participants rece…

This study looks at how two types of laser therapy (high-intensity and low-level) affect nerve function in healthy adults aged 18-30. Participants will be randomly placed into one of three groups: high-intensity laser, low-level laser, or a sham (placebo) group. Over 9 short sess…

This study looks at how diet, exercise, sleep, stress, social connections, and substance use affect heart and mental health in healthy adults aged 40-65 from Belgium, the Netherlands, and Germany. Participants will wear a fitness tracker and complete surveys over 6 months. The go…

This early-phase study will give 144 healthy young adults (ages 18-21) a single dose of THC (7.5 mg) or a placebo in a capsule, then use brain scans and behavioral tasks to measure how THC affects mood, reward processing, and learning. The goal is to understand why some people re…

This study will test whether wearing light-emitting glasses for 20 minutes can improve attention in college students. Researchers at Michigan State University plan to enroll 300 healthy undergraduates. Students will take attention tests before and after using the glasses to see i…

This study will give 20 healthy adults a probiotic capsule every day for 15 days to see if it causes any stomach or other side effects. Participants will fill out questionnaires about their symptoms. The goal is simply to check safety, not to treat any disease.

This study looks at whether having nurses rotate through different heart care units every two months helps them learn more and feel less burned out. About 86 nurses will take part, with some rotating and others staying in their usual unit. Researchers will measure skills, job sat…