HEALTHY

This study tests a new vaccine (V540A) designed to protect against more types of HPV, a virus that can cause cancer. It includes the 9 types covered by the current vaccine plus additional ones. About 525 healthy females aged 16 to 26 will receive either the new or current vaccine…

This study looks at whether eating 50 grams of walnuts every day for 24 weeks can improve blood flow and insulin sensitivity in the brain, and help with thinking and appetite control. The researchers will study 55 adults aged 45–75 who have abdominal obesity but no heart disease.…

This study tests a non-invasive light-based device (SR-NIRS) to measure blood flow and oxygen in the testicles of boys aged 1 month to 18 years. It includes healthy boys and those with sudden scrotal pain to see if the device can tell the difference between testicular torsion and…

This study checks if a new portable device can accurately measure ankle looseness in people with and without ankle problems. Researchers will test it on 62 young adults, including healthy individuals, those with a past sprain, and those with chronic ankle instability. The goal is…

This study tests whether a special probiotic blend (two types of Bifidobacterium longum) can help healthy adults sleep better and feel less stressed during short trips. Sixty participants will take either the probiotic or a placebo daily while traveling. Researchers will measure …

This study looks at whether replacing standard physical education classes with alternative sports like korfball, flag football, kin-ball, and ultimate frisbee can improve motor skills, fitness, and enjoyment in 210 healthy primary school students. Over 8 weeks, researchers will c…

This study looks at whether a supplement made from broccoli can help muscles heal faster after intense exercise. Seventeen healthy adults who haven't done resistance training in the past 6 months will take either the broccoli supplement or a placebo for a week, then do a special …

This study looks at whether a supplement called Phaseolean can help healthy adults manage their blood sugar after eating high-carb meals. Researchers will measure blood sugar levels and feelings of fullness in 12 participants. The goal is to see if Phaseolean can ease the body's …

This study tests a natural supplement called Prosman™ (made from plum extract) in 38 men aged 40-60 with mild-to-moderate prostate enlargement symptoms. Participants take either Prosman™ or a placebo daily for 8 weeks to see if it improves urinary symptoms, hormone levels, and qu…

This study tests whether a daily collagen peptide supplement called AP-Brain can improve attention, focus, and memory in adults aged 35-70 who are stressed but otherwise healthy. Participants will take either a higher or lower dose for 56 days and complete computer tasks and surv…

This study tests whether a special vibrating device can reduce pain and anxiety in children aged 6 to 14 during dental injections. Each child will try both the device and a manual vibration method on separate visits to compare which works better. The goal is to make dental visits…

This study looks at how inflammation affects the inner part of the tooth (the pulp) in people with painful tooth inflammation compared to healthy people. Researchers will measure certain substances in saliva, gum fluid, and tooth pulp to see if they can tell how inflamed the toot…

This study checks if a new device that uses a camera and machine learning can accurately measure foot pressure and foot area. Researchers will compare it to the current standard tool. 150 healthy adults will take part in simple, non-invasive tests.

This study looks at whether healthy young adults (ages 18-29) can improve their cognitive flexibility—the ability to switch between different ways of thinking—through a special training program. Participants will complete thinking tasks and have brain scans to see if training lea…

This study looks at how two types of laser therapy (high-level and low-level) affect nerve function in healthy adults aged 18 to 30. Participants will be randomly placed into one of three groups: high-level laser, low-level laser, or a sham (placebo) group. Over 3 weeks, they wil…

This study looks at how the liver makes new sugar from fat and blood molecules in people with and without type 2 diabetes. Researchers will give special tracers and take blood samples to track this process. The goal is to find new ways to lower blood sugar more directly. About 48…

This study looks at whether showing people a real-time visual display of their swallowing pressure helps them perform swallowing exercises better. Fifty healthy adults aged 18-40 will swallow with and without this biofeedback while a thin pressure-sensing tube measures their thro…

This early-stage study tests the safety and tolerability of a new drug, KR23343, in 92 healthy adults aged 18 to 45. Participants receive either the drug or a placebo, and researchers monitor side effects, lab results, and how the drug moves through the body. The study also check…

This study aims to find the best way to collect and handle stool samples for analyzing gut bacteria. Ten healthy adults will provide samples using different collection methods, and researchers will compare the results to the standard method of freezing fresh stool. The goal is to…

This study looks at how the brain's map of the back changes in people with long-term low back pain compared to healthy volunteers. Participants will lie on a special surface during an MRI scan to see how their brain reacts. The goal is to find brain patterns that could lead to be…

This study looks at how to fairly compare muscle strength among healthy women of different sizes. Researchers will test if using body mass index (BMI) instead of just body weight gives more accurate results. About 112 healthy women will participate in strength tests of their trun…

This study looks at a new idea called Satiety Per Calorie (SPC) — how full a food makes you feel for each calorie it contains. Researchers want to see if foods with higher SPC help people eat fewer calories naturally. They will measure food intake and energy use in 40 healthy men…

This study looks at how growth hormone affects beta-cells, which make insulin, in people with prediabetes (impaired fasting glucose or impaired glucose tolerance). Researchers will measure insulin production in 10 participants to better understand why some people develop type 2 d…

This early-stage study tests whether a new drug, SSS68, is safe and how the body processes it. Fifty healthy adults aged 18-45 will receive a single injection of either the drug or a placebo. The main goal is to check for side effects, not to treat any disease.

This study looks at whether a single dose of ulonivirine changes how the body processes methadone. Fourteen healthy adults who are already on a stable methadone program will take methadone alone and then with ulonivirine. Researchers will measure methadone levels in the blood to …

This early-stage study will check if a single dose of MK-8527 changes how the body processes methadone. Fourteen healthy adults will take both medicines and have their blood tested. The goal is to understand any drug interactions, not to treat a disease.

This study looks at whether using AI to analyze cases and find errors can improve critical thinking, AI skills, and clinical reasoning in nursing students. About 400 students will be split into two groups: one gets AI-based training, the other gets traditional case-based teaching…

This study will compare heart health, mental health, and lifestyle habits (like diet, sleep, and exercise) among 1,000 healthy adults aged 40-65 living in four regions of Belgium, the Netherlands, and Germany. Participants will wear a fitness tracker and complete questionnaires. …

This early-stage study looks at how itraconazole changes the way the body handles a drug called LY4395089. Fourteen healthy adults will stay at a research unit for several days and give blood samples. The goal is to understand the drug's processing, not to treat any disease.

This study tests whether placebo suggestions work better when they match a person's natural motivational style (e.g., focusing on achieving goals vs. avoiding risks). 60 healthy adults will receive heat pain and rate their experience. The goal is to understand how personalizing s…

This early-stage study tests a new medicine, PF-08065010, in 100 healthy adults aged 18-65 to see if it is safe and how the body processes it. Participants receive either the drug or a placebo as a shot or IV, with some getting a single dose and others monthly doses for 3 months.…

This early-stage study looks at how the body processes a new medicine called PF-08049820. Healthy adults will take different versions of the drug, with or without food, and also with another medicine that lowers stomach acid. The goal is to understand the best way to deliver the …

This study looks at how different kinds of light affect attention and learning in college students. About 300 healthy Michigan State University undergraduates will either wear special light-enriched glasses in class or be part of a control group. Researchers will measure how fast…

This study looks at how the green-red color axis (called a*) contributes to tooth whiteness after a standard bleaching treatment. Ten healthy adults aged 18 to 65 will have their tooth color measured before and after bleaching. The goal is to better understand what makes teeth lo…

This study tests how well two different versions of the drug eltrekibart are absorbed when injected under the skin. About 60 healthy adults will receive a single dose and be monitored for about 17 weeks. The goal is to compare the drug levels in the blood and check for any side e…

This study looks at how different liquid versions of the drug osivelotor taste and how well they get into the blood compared to a tablet. It also checks if taking the drug with food or an antacid changes absorption. About 52 healthy adults aged 18 to 65 will take part. The goal i…

This study looks at how eating a high-fat or low-fat meal changes the way a new drug called FWD1802 is processed in the body. It involves 18 healthy Chinese adults who will take the drug once under different meal conditions. The goal is to understand if food affects drug levels, …

This early-stage study tests a new drug, SSS67, in 52 healthy adults to see if it is safe and how the body processes it. Participants receive a single dose of the drug or a placebo by IV. The study does not aim to treat any disease, but will also look at changes in weight and met…

This study tests whether a 16-week moderate-to-vigorous physical activity program can improve physical fitness and alter gut bacteria in healthy school-aged children. About 113 kids aged 6-9 will be randomly assigned to either the exercise program or a control group. Researchers …

This study looks at whether different types of physical activity can help healthy first-year university students think better and feel less stressed. Researchers will compare high-intensity exercise, Tai Chi, and computer brain games over 12 weeks. The goal is to see which approa…

This study looks at whether drinking enough plain water every day for 4 weeks can change how thirsty healthy young adults feel. It involves 120 people who usually don't drink much plain water but get enough total fluids from other drinks. The goal is to understand if our bodies c…

This early-stage study tests whether a single shot of HS-20136-2 is safe and tolerable in healthy adults aged 18-65. Participants receive either the drug or a placebo, and researchers monitor for side effects and how the drug moves through the body. No treatment benefit is expect…

This study looks at how taking a new combination diabetes pill with or without food changes the way the body absorbs the medication. It involves 28 healthy adults in Thailand who will take the pill once while fasting and once after a meal. The goal is to understand food's effect …

This study will test whether a digital chatbot can help 1,000 parents and caregivers in the UK better recognize false information about routine childhood vaccines. Participants will interact with the chatbot and then be tested on their ability to tell true from false vaccine stat…

This study looks at whether using artificial intelligence (AI) in case discussions helps midwifery students become more comfortable and skilled with AI tools. About 81 third- and fourth-year students will take part. The goal is to see if AI can boost their clinical thinking and p…

This study tests whether a virtual reality (VR) program can help nursing students improve how they counsel day surgery patients. Sixty nursing students will take part; half will use the VR program alongside their regular classes, and half will only have regular classes. The main …

This study looks at how two different versions of gecacitinib hydrochloride tablets are absorbed and processed by the body in healthy adults. About 64 participants aged 18 to 45 will take a single dose under fasting conditions. The goal is to compare the drug levels in the blood,…

This study looks at how different forms of chickpeas—like whole, pureed (hummus), or as pasta—change the way your body uses energy. Researchers will measure fat, carbohydrate, and protein burning in 204 healthy adults over 12 weeks. The goal is to understand if processing affects…

This study tests whether a single 40-minute session of exergaming-based seated Tai Chi can improve memory and thinking skills in healthy young (18-30) and older (60-75) adults. Participants will try both the Tai Chi game and a simple stretching routine on separate days, while the…

This study looks at whether a program led by senior nursing students—using videos filmed in real hospital settings, interactive sessions, and a guided tour—can help first-year nursing students feel less overwhelmed and adapt better during their first time in a clinical environmen…

This study looks at how a new curcumin capsule is absorbed in the body compared to a similar product. It involves 12 healthy adults who take the capsules after a meal. Blood tests measure the amount of curcumin in the body over time. The goal is to see if the new capsule delivers…

This study looks at how a structured physiotherapy program after cosmetic leg-lengthening surgery affects daily movement and physical function. It will involve 54 adults aged 18-45 who have the surgery. Researchers will measure changes in strength, walking, pain, and independence…

This study tests whether a mobile app that uses AI and game-like features can help young adults (ages 18-24) who face food insecurity make healthier food choices. About 114 UC Davis students will use either a basic food-tracking app or a version with extra nudges and rewards for …

This study will test a new ultrasound device that creates 4D (3D + real-time) images of the upper airway, head, and neck. Researchers want to see if this device can show areas that regular ultrasound cannot, like behind the jaw or windpipe. About 100 healthy adults will lie still…

This study tests a new AI chatbot designed to help parents resist false information about vaccines. Researchers will enroll 5,000 parents from five European countries. The chatbot teaches parents to recognize common tricks used in vaccine misinformation. The goal is to see if the…

This study tests if a simple camera can track how movement changes during large exercises like reaching and stepping. Healthy adults will do six exercises while a camera records them. The goal is to see if the camera can detect when movements get smaller over time, which could he…

This study checks if a special camera that looks at tiny blood vessels under the tongue can give consistent results. It will include 200 people: healthy volunteers and critically ill patients in the ICU. Researchers will take multiple measurements to see if the method is reliable…

This early-stage study will give verducatib pills daily for 4 weeks to 12 healthy Chinese adults aged 18-55. The goal is to measure how the drug moves through the body and check for any side effects. Participants will not receive any direct medical benefit, but results will help …

This study looks at whether taking aspirin at specific times of day can prevent the blood pressure increases that sometimes happen with the pain reliever celecoxib. Researchers will measure blood pressure in 60 healthy adults over time. The goal is to understand how timing affect…

This study looks at how mood, behavior, and brain activity change in young adults (ages 18-21) who use cannabis. Researchers will use brain scans and questionnaires to understand why some people respond differently to the same drug. The goal is to learn more about individual diff…

This study looks at whether the natural daily rise and fall of cortisol (a stress hormone) is reflected in the fluid around eggs in women undergoing IVF. Researchers will collect blood and follicular fluid samples at 8 a.m. and 8 p.m. from 20 healthy women aged 18-35. The goal is…

This study looks at whether providing free school meals to Danish children aged 10 to 15 can improve their health, well-being, and learning. About 3,200 kids will be followed for 1.5 years, with some receiving free meals and others not. Researchers will measure changes in quality…

This study looks at whether moving nurses between different heart-care units every two months helps them learn more and feel less burned out. About 86 nurses will take part, with some rotating and others staying in place. Researchers will measure skills, job satisfaction, and wor…

This study compares two similar oral drugs in 60 healthy adults aged 19 to 64. Participants will take a single dose of each drug at different times to measure how the body processes them and to check for side effects. The goal is to gather information, not to treat any disease.

This study will test a non-invasive technique called focused ultrasound on the brains of 25 healthy adults aged 18-55. Researchers want to see how it changes brain signals and chemical levels. The goal is to understand how the method works and if it is safe, not to treat any dise…

This study compares two brain stimulation methods—standard electrical stimulation and a newer magnetic version—to see which better improves working memory. About 102 healthy adults will perform memory tasks while receiving stimulation. The goal is to find a more comfortable and e…

This early-stage study tests an experimental drug called LY4302814 in 150 healthy adults to see if it is safe and how the body handles it. Participants will receive either the drug or a placebo and stay overnight at a clinic for up to 9 days. The study lasts about 6 months and do…

This study tests a new type of eye scanner (PS-OCT) to see if it can take clearer pictures of the retina's nerve fibers. About 20 healthy adults aged 18-85 will have their eyes imaged. The goal is to measure how well the device works, not to treat any disease.

This small pilot study looks at how a new probiotic supplement (BEO001) changes gene activity and sugar patterns in the small intestine of 8 healthy adults. Participants take the probiotic alone, with fiber, or a placebo, and provide gut tissue samples via a scope the next day. T…

This study checks if taking a probiotic capsule every day for 15 days causes any stomach problems in healthy adults. Twenty volunteers will take the probiotic and report any side effects like bloating or discomfort. The goal is simply to see if the probiotic is safe, not to treat…

This study looks at how non-invasive brain stimulation (rTMS) affects two different areas of the cerebellum—one linked to movement and one linked to thinking. Forty healthy adults will receive either stimulating, inhibiting, or fake (placebo) stimulation in random order. The goal…