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Breathing new life into muscle science: how oxygen and carbon dioxide shape diaphragm and limb function

NCT ID NCT07701603

Knowledge-focused Sponsor: Swiss Federal Institute of Technology Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 14, 2026 · Last updated Jul 15, 2026 · Updated 1 time

Summary

This study investigates how different levels of oxygen and carbon dioxide in the blood affect the strength and function of the diaphragm and leg muscles, both at rest and during exercise. Sixteen healthy, non-smoking adults will breathe various gas mixtures—including low oxygen (hypoxia), high carbon dioxide (hypercapnia), or a combination—for two hours, followed by a maximal breathing effort test. The goal is to understand how blood gas changes influence neuromuscular performance, which could inform treatments for respiratory and muscle disorders.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
breathing gas mixtures (room air, hypoxia, hypercapnia, or combination)
What this could lead to
If successful, this could improve understanding of how low oxygen or high carbon dioxide levels affect breathing and leg muscles, potentially guiding care for people with lung or respiratory conditions.
What could go wrong
This is a small, early-stage study in healthy volunteers, so results may not apply to people with illnesses. The gas exposures may cause temporary discomfort like dizziness or shortness of breath.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 16 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Dec 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 55 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * healthy * non.smoking * normal lung function * BMI: 18.5-29.9 kg/m2 * willing to adhere to study rules Exclusion Criteria: * Acute illness or chronic conditions of the gastrointestinal tract, and health conditions affecting metabolism, the cardiovascular or the respiratory system, or sleep * Intake of medications affecting metabolism, the cardiovascular, the neuromuscular or the respiratory system, or sleep * Any metal or electronics inside of the body * Presence of cardiac pacemaker, implanted defibrillators or implanted neurostimulators * History of seizures or epilepsy * Tattoos on the stimulation sites * Previous enrolment in this study * For women: Pregnancy, breastfeeding, or intention to become pregnant during the study

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As listed by the trial registrant

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Healthy

How to take part

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  1. The official record

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