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Morning vs. evening: cortisol levels in egg follicles under study

NCT ID NCT06877429

Knowledge-focused Sponsor: ART Fertility Clinics LLC Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

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The trial has finished. Results may not be published yet.
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Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

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Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

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Status unknown
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First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether the natural daily rise and fall of cortisol in the blood is also seen in the fluid surrounding eggs in the ovary. Researchers will collect blood and follicular fluid samples from 20 women undergoing IVF, either at 8 a.m. or 8 p.m. The goal is to better understand how cortisol might help control inflammation after ovulation.

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Study facts

What this study's own registry entry says, in plain language.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Dec 2026

An estimate. Start dates often move.

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Healthy women

Ages

18 to 35 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Indication for IVF / ICSI - treatment * Age ≥ 18 years and ≤ 35 years * Body weight: 19 - 29 kg/m2 * Ovarian reserve parameters in the adequate age - range, determined by Anti-Muellerian-Hormone (AMH) and Antral Follicle Count (AFC) (Shebl 2011, Hamdine 2015) * Regular cycle (25-35 days) Exclusion Criteria: * Age \< 18 years and \> 35 years * Body weight \< 60 kg and \> 90 kg * Ovarian reserve parameters outside the adequate age - range, determined by Anti-Muellerian-Hormone (AMH) and Antral Follicle Count (AFC) (Shebl 2011, Hamdine 2015) * Proven poor responder in preceding IVF-treatment-cycle, according to the Bologna criteria: at least two of the following three features must be present: (i) Advanced maternal age (≥40 years) or any other risk factor for POR (poor ovarian response) (ii) A previous POR (≤3 oocytes with a conventional stimulation protocol) (iii) An abnormal ovarian reserve test (i.e. AFC \< 5-7 follicles or AMH \< 0.5 -1.1 ng/ml) * Two episodes of POR after maximal stimulation are sufficient to define a patient as a poor responder in the absence of advanced maternal age or abnormal ORT * Diagnosis of polycystic ovarian syndrome (PCOS), according to Rotterdam criteria * Endometriosis stage 3 or 4 AFS (American Fertility Society) * Irregular cycle (\< 25 days and \> 35 days) * Treatment with GnRH-analogues during the previous 6 months * Intake of contraceptive pill (OCP) or any hormonal treatment during the last 3 months

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As listed by the trial registrant

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Healthy

How to take part

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  2. The official record

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Contacts and locations

Locations

  • ART Fertility Clinics LLC

    Abu Dhabi, United Arab Emirates

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