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Do your skin creams disrupt your microbiome? new study investigates

NCT ID NCT03437005

Recruiting now Knowledge-focused Sponsor: University of California, Davis Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether two common topical medications—a steroid (desonide) and an antifungal (ketoconazole)—change the types and amounts of bacteria living on healthy skin. Twenty-four adults will apply the creams twice daily for two weeks, and researchers will compare skin bacteria before and after treatment. The goal is to understand how everyday skin products might affect the skin's natural microbiome.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Desonide 0.05% ointment and Ketoconazole 2% cream
What this could lead to
If successful, this could help doctors understand how common skin treatments affect the skin's natural bacteria, potentially guiding safer use.
What could go wrong
This is a small, early-phase study in healthy people, so results may not apply to those with skin conditions. It only measures microbiome changes, not treatment benefits or risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • University of California, Davis, Department of Dermatology

    RECRUITING

    Sacramento, California, 95816, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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