New PET tracer could help doctors see inflammation in the body

NCT ID NCT07625345

Recruiting now Knowledge-focused Sponsor: National Institute of Mental Health (NIMH) Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 08, 2026 · Updated 8 times

Summary

This study tests a new radioactive tracer called [11C]ZTP-1 to see if it can measure a protein called PDE4B in the brain and body. PDE4B helps control inflammation and brain signals. Forty healthy adults will get the tracer and have PET/CT scans. The goal is to see if this tracer can be used in future studies to monitor diseases or treatment effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: 11C-ZTP-1 (a radioactive tracer injected intravenously for PET imaging)
What this could lead to: If successful, this tracer could help doctors measure PDE4B levels in the body, potentially improving how they monitor diseases or treatment responses.
What could go wrong: This is an early Phase 1 study with only 40 healthy participants. It is designed to test the tracer's safety and imaging ability, not to treat any disease. The tracer may not work as expected in future studies.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY

Contacts and locations

Locations

National Institutes of Health Clinical Center
RECRUITING

Bethesda, Maryland, 20892, United States

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