Heart-Healthy supplement may counter painkiller risks
NCT ID NCT04765644
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed study tested whether taking L-arginine, a natural amino acid, could prevent blood vessel damage caused by the painkiller celecoxib. Forty-four healthy men took either celecoxib alone, celecoxib plus L-arginine, or placebos for one week. Researchers measured changes in blood vessel function and stiffness to see if the supplement offered protection.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- L-arginine (an amino acid supplement) and celecoxib (an NSAID painkiller)
- What this could lead to
- If it works, this could point toward a way to reduce heart risks from common painkillers like celecoxib.
- What could go wrong
- This was a small, early-phase study in only 44 healthy men, so results may not apply to the general public or people with health conditions.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Imperial College Clinical Research Facility
London, w12 0HS, United Kingdom
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