Kidney health may change how body handles cancer drug

NCT ID NCT05469100

Completed Knowledge-focused Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study looked at how the body processes the drug selpercatinib (LOXO-292) in people with different levels of kidney function. Researchers gave a single dose to 37 volunteers—some with healthy kidneys and some with kidney impairment—and measured drug levels in the blood and urine over 9 days. The goal was to see if kidney problems change how much drug stays in the body or how fast it is removed, which could guide future dosing recommendations.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Selpercatinib (also known as LOXO-292)
What this could lead to: If successful, this study could help doctors determine the right dose of selpercatinib for patients with kidney problems, making the drug safer and more effective for them.
What could go wrong: This is an early-phase, small study (37 participants) focused on drug levels, not on treating a disease. Results may not apply to all patients or predict real-world outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

impaired renal function disease kidney failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY RENAL INSUFFICIENCY

Contacts and locations

Locations

Anaheim Regional Center

Anaheim, California, 92801, United States
Clinical Pharmacology of Miami

Miami, Florida, 33014, United States
Orange County Research Center

Tustin, California, 92780, United States
Orlando Clinical Research Center

Orlando, Florida, 32809, United States
Riverside Clinical Research

Edgewater, Florida, 32132, United States
Stanford Health Care, Valley Care Program

Pleasanton, California, 94588, United States

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