Drug interaction check: will fluconazole change how BI 425809 works?
NCT ID NCT05076409
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed Phase 1 study tested how the antifungal drug fluconazole changes the levels of the experimental drug BI 425809 in the blood. Fifteen healthy men took a single dose of BI 425809 alone, and later took it while also taking fluconazole daily. The goal was to see if fluconazole affects how much BI 425809 stays in the body, which helps guide future dosing in patient studies.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
BI 425809 (Iclepertin) and fluconazole
What this could lead to
If successful, this study will help determine the right dose of BI 425809 when taken with fluconazole, supporting future trials for conditions like schizophrenia.
What could go wrong
This is a very early, small study in healthy volunteers, not patients. It only looks at drug levels, not whether the drug works for any disease.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Humanpharmakologisches Zentrum Biberach
Biberach, 88397, Germany