New cream aims to fade dark spots naturally

NCT ID NCT05986123

Completed Symptom relief Sponsor: USMARI Research & Innovation Centre Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a cream made from natural plant extracts, niacinamide, and arbutin to see if it safely lightens dark spots (post-inflammatory hyperpigmentation) on the skin. Twenty-five healthy Malaysian adults used the cream twice daily for 20 weeks. Researchers measured changes in skin spots and checked for side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Topical cream containing niacinamide, arbutin, Scutellaria Baicalensis Root Extract, Centella Asiatica Extract, and Camellia Sinensis Leaf Extract
What this could lead to: If it works, this could offer a safe, natural option for fading dark spots left after skin injuries or inflammation.
What could go wrong: This was a small, completed study with only 25 healthy adults, so results may not apply to everyone. The cream is cosmetic and not a treatment for any disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Hyperpigmentation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY

Contacts and locations

Locations

Ungku Shahrin Medical Aesthetic Research & Innovation (USMARI) Centre

Petaling Jaya, Selangor, 47810, Malaysia

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