Coffee break for the brain: study probes Caffeine's effect on brain oxygen

NCT ID NCT07191665

Completed Knowledge-focused Sponsor: Société des Produits Nestlé (SPN) Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study looked at how caffeine and L-Arginine affect brain oxygen levels during mental tasks in 37 healthy adults aged 25-35. Participants took capsules containing caffeine, caffeine plus L-Arginine, or a placebo, and then performed memory tests while their brain oxygenation was measured using a special light-based technique (fNIRS). The goal was to see if these dietary components change brain activity patterns.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Caffeine and L-Arginine
What this could lead to: If successful, this could help researchers understand how certain dietary components like caffeine affect brain activity and thinking.
What could go wrong: This is a small, early-stage study in healthy adults, so results may not apply to the general population or lead to any treatment.

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Conditions

The condition(s) this trial relates to.

Mental Fatigue

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY

Contacts and locations

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Locations

Clinical Innovation Lab

Lausanne, Canton of Vaud, 1000, Switzerland

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