Can a natural supplement change your genes? new study explores

NCT ID NCT07127445

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed trial looked at whether a daily dietary supplement containing oleoylethanolamide (OEA), ginger extract, and lavender essential oil can affect gene expression and health markers in 92 healthy adults aged 18-64 with a BMI of 25-30. Participants took two capsules daily for 12 weeks and provided blood and urine samples at three visits. The study measured changes in gene methylation, HbA1c, and safety labs, aiming to understand the supplement's metabolic and epigenetic impact.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dietary supplement containing oleoylethanolamide (OEA), ginger extract, and lavender essential oil
What this could lead to
If successful, this could help understand how certain natural compounds influence gene activity and basic health measures like weight and blood pressure.
What could go wrong
This is a small, early-stage study in healthy volunteers, so results may not apply to people with medical conditions. The supplement's effects on disease are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

92 people

The number who actually took part.

Started

Aug 2025

Finished

Dec 2025

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 64 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults ages 18-64 years old * BMI 25-30 inclusive (self-reported for screening, confirmed at first study visit) * For purposes of blood collection and other in-person procedures: o Reside within driving distance of the study center or be willing to travel to the study center * Willing and able to undergo three blood draws over 12 weeks * Willing to wash out of all internally-consumed essential oils or botanical products for at least 2 weeks prior to starting the study, and willing to maintain the washout for the duration of the study (14 weeks). * Willing and able to consume study product twice daily for about 12 weeks * Willing to track consumption of study product * Willing to keep diet, exercise, sleep habits, and current non-study supplement use the same throughout the study * Willing to limit alcohol consumption to "social drinking" (typically no more than 3 drinks per day and 7 per week) during the study * History of alcohol consumption limited to "social drinking" (typically no more than 3 drinks per day and 7 per week) * Willing to avoid recreational drugs and smoking/vaping for the duration of the study (approximately 12 weeks) * No metabolic disease (BMI\>30, diagnosis and treatment of hypertension, diabetes, or dyslipidemia) * No major diseases under treatment by doctor (Medical Reviewer's discretion) * No pregnancy within the last 60 days or currently breastfeeding (females) * No allergy to olive oil, lavender essential oil, ginger oleoresin/extract/essential oil, or OEA. * No regular internal consumption of lavender essential oil, ginger oleoresin or extract, or OEA within the last 1 month (regularly is defined as dosing daily for more than 2 consecutive weeks, or dosing more than 2-3 times per week for 4 consecutive weeks) * No evidence of medical condition, significant disease or disorder, medication, or surgery within the past 12 months that may, in the judgment of the medical provider, put the participant at risk or affect study results, procedures, or outcomes * No recreational drug or smoking/vaping use in the past 1 month * Not currently or previously participating in any other clinical trial within the last 30 calendar days Exclusion Criteria: * Failure to meet all inclusion criteria

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • doTERRA International

    Pleasant Grove, Utah, 84062, United States

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