Kidney health may change how this drug works

NCT ID NCT06814119

Completed Knowledge-focused Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how the drug calderasib (MK-1084) behaves in people with moderate or severe kidney problems compared to healthy volunteers. Researchers will measure drug levels in the blood after a single dose to see if kidney function changes how the body processes it. The study also checks for side effects. 34 adults took part, and the results will help guide future dosing for patients with kidney impairment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: calderasib (MK-1084) oral tablet
What this could lead to: If successful, this study could help doctors determine the right dose of calderasib for people with kidney problems, making the drug safer and more effective for them.
What could go wrong: This is a very early (Phase 1) study with only 34 participants, so results may not apply to everyone. It only looks at a single dose, not long-term use, and kidney impairment may affect the drug differently than expected.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

impaired renal function disease kidney failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY RENAL IMPAIRMENT

Contacts and locations

Locations

Orlando Clinical Research Center ( Site 0002)

Orlando, Florida, 32809, United States
Research by Design ( Site 0001)

Chicago, Illinois, 60643, United States

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