Can ecstasy tame the bad trips of magic mushrooms?
NCT ID NCT06884514
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed Phase 1 study in 24 healthy adults tested whether taking MDMA (the drug in ecstasy) alongside psilocybin (the active ingredient in magic mushrooms) reduces anxiety and negative feelings while boosting positive mood and trust. Researchers measured mood, blood pressure, heart rate, and body temperature to see if the combination is safer and more pleasant than psilocybin alone. The goal is to gather knowledge that could eventually improve psychedelic-assisted therapy for conditions like depression.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
psilocybin and MDMA
What this could lead to
If it works, this could point toward safer psychedelic-assisted therapy by using MDMA to reduce anxiety and negative experiences from psilocybin.
What could go wrong
This is a very early, small study in healthy volunteers, not patients. The combination may still cause side effects or not translate to therapeutic settings.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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Contacts and locations
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Locations
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University Hospital Basel
Basel, 4031, Switzerland