Cold therapy could replace needle numbing for Children's dental work

NCT ID NCT07198022

Completed Symptom relief Sponsor: Ondokuz Mayıs University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether cold application (cryotherapy) works as well as standard numbing gels and sprays to reduce pain from dental injections in children. 100 kids aged 7 to 10 were divided into four groups: one received a lidocaine spray, one a benzocaine gel, one cold distilled water, and one cold lidocaine spray. Researchers measured pain, anxiety, taste, and vital signs to see which method worked best.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: lidocaine, benzocaine, and cryotherapy (distilled water)
What this could lead to: If successful, this could show that cold application (cryotherapy) works as well as numbing gels or sprays for reducing pain from dental injections in children.
What could go wrong: This is a small, completed Phase 4 study with only 100 children, so results may not apply to all kids or settings. Cryotherapy might not be as effective as standard anesthetics for everyone.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CRYOTHERAPY HEALTHY PEDIATRIC DENTISTRY TOPICAL ANESTHESIA

Contacts and locations

Locations

Ondokuz Mayıs University, Faculty of Dentistry

Samsun, Turkey (Türkiye)

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