Healthy volunteers help uncover best way to take cancer pill
NCT ID NCT05468164
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This completed Phase 1 study looked at how food and the heartburn drug omeprazole affect the absorption of selpercatinib, a cancer medication. Twenty healthy adults took selpercatinib under different conditions—with a high-fat meal, on an empty stomach, and after taking omeprazole. The goal was to see how fast the drug enters the bloodstream and how long it stays in the body, helping guide future dosing instructions.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Selpercatinib (cancer drug) and omeprazole (heartburn drug)
- What this could lead to
- If successful, this study could help doctors understand how to take selpercatinib with or without food and heartburn medication for best absorption.
- What could go wrong
- This is a small, early-stage study in healthy people, not patients. Results may not apply to those with cancer or other conditions.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Celerion
Tempe, Arizona, 85283, United States
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