Healthy volunteers help uncover best way to take cancer pill
NCT ID NCT05468164
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This completed Phase 1 study looked at how food and the heartburn drug omeprazole affect the absorption of selpercatinib, a cancer medication. Twenty healthy adults took selpercatinib under different conditions—with a high-fat meal, on an empty stomach, and after taking omeprazole. The goal was to see how fast the drug enters the bloodstream and how long it stays in the body, helping guide future dosing instructions.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Selpercatinib (cancer drug) and omeprazole (heartburn drug)
What this could lead to
If successful, this study could help doctors understand how to take selpercatinib with or without food and heartburn medication for best absorption.
What could go wrong
This is a small, early-stage study in healthy people, not patients. Results may not apply to those with cancer or other conditions.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for HEALTHY are added.
By submitting, you agree to our Terms of use
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Celerion
Tempe, Arizona, 85283, United States