Healthy volunteers help uncover calderasib drug interactions
NCT ID NCT06719557
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed Phase 1 study looked at how two common drugs—itraconazole (an antifungal) and phenytoin (a seizure medicine)—change the amount of calderasib in the blood of 28 healthy adults. Researchers measured calderasib levels over time after a single dose, alone and with each other drug. The goal was to understand potential drug interactions, not to treat any disease.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Calderasib (also called MK-1084), itraconazole, and phenytoin
What this could lead to
If successful, this study will help determine the right dosing of calderasib when taken with other common drugs.
What could go wrong
This is an early-phase study in healthy volunteers, not patients. It only measures drug levels, not effectiveness or safety for any disease.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Celerion (Site 0001)
Lincoln, Nebraska, 68502, United States