Healthy volunteers help uncover calderasib drug interactions
NCT ID NCT06719557
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed Phase 1 study looked at how two common drugs—itraconazole (an antifungal) and phenytoin (a seizure medicine)—change the amount of calderasib in the blood of 28 healthy adults. Researchers measured calderasib levels over time after a single dose, alone and with each other drug. The goal was to understand potential drug interactions, not to treat any disease.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Calderasib (also called MK-1084), itraconazole, and phenytoin
- What this could lead to
- If successful, this study will help determine the right dosing of calderasib when taken with other common drugs.
- What could go wrong
- This is an early-phase study in healthy volunteers, not patients. It only measures drug levels, not effectiveness or safety for any disease.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Celerion (Site 0001)
Lincoln, Nebraska, 68502, United States
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