New pill aims to relieve constipation from painkillers

NCT ID NCT01040637

Completed Symptom relief Sponsor: Glycyx Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a drug called TD-1211 in healthy volunteers and people with constipation caused by opioid painkillers. The goal was to see if it is safe and helps with bowel movements. Participants took different doses of TD-1211 or a placebo, and researchers monitored their safety and how well the drug worked.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: TD-1211
What this could lead to: If it works, this could lead to a new treatment for opioid-induced constipation, helping people on long-term opioids have more regular bowel movements.
What could go wrong: This is an early phase 1/2 trial with only 102 participants, so results may not apply to everyone. The drug may not work better than a placebo or could cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

opioid-induced constipation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY OPIOID INDUCED CONSTIPATION

Contacts and locations

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Locations

Clinical Research Unit

Pasadena, California, 91105, United States
Clinical Research Unit

San Antonio, Texas, 78209, United States
Clinical Research Unit

Salt Lake City, Utah, 84106, United States

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