Naloxone nasal spray vs. injection: new study aims to improve overdose rescue

NCT ID NCT06306391

Completed Knowledge-focused Sponsor: Parc de Salut Mar Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed Phase 1 trial in 8 healthy volunteers compared how naloxone works when given as a nasal spray versus an injection. Researchers measured drug levels in the blood and effects on heart rate and blood pressure. The goal was to improve computer models that predict how nasal naloxone reaches the brain, which could help refine overdose treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: naloxone
What this could lead to: If successful, this could improve computer models that predict how well nasal naloxone works, potentially leading to better overdose treatments.
What could go wrong: This is a very small, early-phase study in healthy people, not in an overdose situation. The results may not translate to real-world emergency use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY

Contacts and locations

Locations

Hospital del Mar Research Institute

Barcelona, 08003, Spain
IMIM (Hospital del Mar Medical Research Institute)

Barcelona, 08003, Spain

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