Naloxone nasal spray vs. injection: new study aims to improve overdose rescue
NCT ID NCT06306391
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed Phase 1 trial in 8 healthy volunteers compared how naloxone works when given as a nasal spray versus an injection. Researchers measured drug levels in the blood and effects on heart rate and blood pressure. The goal was to improve computer models that predict how nasal naloxone reaches the brain, which could help refine overdose treatments.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
naloxone
What this could lead to
If successful, this could improve computer models that predict how well nasal naloxone works, potentially leading to better overdose treatments.
What could go wrong
This is a very small, early-phase study in healthy people, not in an overdose situation. The results may not translate to real-world emergency use.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Hospital del Mar Research Institute
Barcelona, 08003, Spain
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IMIM (Hospital del Mar Medical Research Institute)
Barcelona, 08003, Spain