New drug targets tough cancers with KRAS G12D mutation

NCT ID NCT06586515

Recruiting now Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase study tests a new drug, LY3962673, in people with advanced solid tumors that have a specific KRAS G12D mutation, including pancreatic, lung, and colorectal cancers. The main goals are to check safety and see if the drug shrinks tumors, given alone or with chemotherapy. About 630 participants will be enrolled, and the study lasts around 5 years.

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Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal neoplasm non-small cell lung carcinoma pancreatic ductal adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLORECTAL CANCER NON-SMALL CELL LUNG CANCER PANCREATIC DUCTAL ADENOCARCINOMA

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Aichi Cancer Center Hospital
RECRUITING

Nagoya, 464-8681, Japan
Azienda Ospedaliera Universitaria - Universita degli Studi della Campania Luigi Vanvitelli
RECRUITING

Naples, 80138, Italy
Barbara Ann Karmanos Cancer Institute
RECRUITING

Detroit, Michigan, 48201, United States
Beijing Cancer hospital
NOT_YET_RECRUITING

Beijing, 100142, China
Cancer Institute & Hospital, Chinese Academy of Medical Sciences
NOT_YET_RECRUITING

Beijing, 100021, China
Centre Leon Berard
NOT_YET_RECRUITING

Lyon, 69373, France
Centre d'Essais Precoces en Cancerologie de Marseille (CEPCM) - AP-HM Hopital de La Timone
NOT_YET_RECRUITING

Marseille, 13005, France
Centro Ricerche Cliniche di Verona s.r.l.
RECRUITING

Verona, 37134, Italy
Charite Universitaetsmedizin Berlin
RECRUITING

Berlin, 10117, Germany
City of Hope
RECRUITING

Duarte, California, 91010, United States
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Community Health Network
RECRUITING

Indianapolis, Indiana, 46250, United States
Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Duke University Medical Center
RECRUITING

Durham, North Carolina, 27710, United States
Emory University School of Medicine
RECRUITING

Atlanta, Georgia, 30322, United States
Florida Cancer Specialists - Lake Nona - Sarah Cannon Research Institute
RECRUITING

Orlando, Florida, 32827, United States
Fred Hutchinson Cancer Center
RECRUITING

Seattle, Washington, 98109, United States
Fudan University Shanghai Cancer Center
NOT_YET_RECRUITING

Shanghai, 200032, China
Harbin Medical University Cancer Hospita
NOT_YET_RECRUITING

Harbin, 150081, China
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, 28041, Spain
Hospital Universitario Vall d'Hebron
RECRUITING

Barcelona, 08035, Spain
Huntsman Cancer Institute
RECRUITING

Salt Lake City, Utah, 84112, United States
Institut Gustave Roussy
NOT_YET_RECRUITING

Villejuif, 94805, France
Kanagawa cancer center
RECRUITING

Kanagawa, 241-8515, Japan
Kansai Medical University Hospital
RECRUITING

Osaka, 573-1191, Japan
Klinikum der Ludwig-Maximilians-Universitaet Muenchen
RECRUITING

München, 81377, Germany
MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Massachusetts General Hospital
NOT_YET_RECRUITING

Boston, Massachusetts, 02114, United States
National Cancer Center Hospital
RECRUITING

Tokyo, 104-0045, Japan
National Cancer Center Hospital East
RECRUITING

Chiba, 277-8577, Japan
New York University (NYU) Langone Medical Center
RECRUITING

New York, New York, 10016, United States
Oncopole Claudius Regaud
NOT_YET_RECRUITING

Toulouse, 31059, France
Princess Margaret Hospital
RECRUITING

Toronto, M5G 2M9, Canada
START Dublin Early Phase Clinical Trials Unit
RECRUITING

Dublin, D07 R2WY, Ireland
Sarah Cannon Research Institute
RECRUITING

Nashville, Tennessee, 37203, United States
Sarah Cannon Research Institute at HealthOne
RECRUITING

Denver, Colorado, 80218, United States
Sibley Memorial Hospital
RECRUITING

Washington D.C., District of Columbia, 20016, United States
South Texas Accelerated Research Therapeutics (START)
RECRUITING

San Antonio, Texas, 78229, United States
South Texas Accelerated Research Therapeutics (START) Barcelona- HM Nou Delfos
RECRUITING

Barcelona, 08023, Spain
South Texas Accelerated Research Therapeutics (START) Madrid - Hospital Fundacion Jimenez Diaz
RECRUITING

Madrid, 28040, Spain
South Texas Accelerated Research Therapeutics (START) Midwest
RECRUITING

Grand Rapids, Michigan, 49546, United States
The Ottawa Hospital
RECRUITING

Ottawa, K1H 8L6, Canada
UOC Fase I - Fondazione Policlinico Universitario A. Gemelli IRCCS - Universita Cattolica del Sacro Cuore
RECRUITING

Roma, 00168, Italy
USO - US Oncology Research Network
RECRUITING

Nashville, Tennessee, 37203, United States
Universitaetsklinikum Carl Gustav Carus Dresden
RECRUITING

Dresden, 01307, Germany
Universitaetsklinikum Essen
RECRUITING

Essen, 45147, Germany
University of California, Los Angeles (UCLA)
RECRUITING

Santa Monica, California, 90404, United States
University of Cincinnati (UC) - Cancer Institute
RECRUITING

Cincinnati, Ohio, 45267, United States
University of Pittsburgh Medical Center (UPMC) - Hillman Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
University of Wisconsin - Carbone Cancer Center
RECRUITING

Madison, Wisconsin, 53792, United States
Vanderbilt University School of Medicine
RECRUITING

Nashville, Tennessee, 37215, United States

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