Eli Lilly And Company

This study tested whether the injectable medication tirzepatide helps control blood sugar and promotes weight loss in Chinese adults with type 2 diabetes. 206 participants were randomly assigned to receive either tirzepatide or a placebo injection for several months. Researchers …

This study tested a weekly injection called LY3437943 (retatrutide) in people who are overweight or have obesity and also have painful knee osteoarthritis. The main goals were to see if the treatment safely reduced knee pain and helped participants lose weight over about 77 weeks…

This small, early-stage study aimed to check the safety and side effects of combining two drugs, abemaciclib and darolutamide, for men with advanced prostate cancer that had spread and stopped responding to standard hormone therapy. It involved 10 participants and looked at how w…

This early-stage study tested the safety of a new oral medication called LY3549492 for type 2 diabetes in Chinese adults. Thirty-six participants took daily doses of either the drug or a placebo for about 18 weeks. The main goal was to check for side effects and see how the drug …

This study tested the safety and effectiveness of a drug called lebrikizumab for adults and adolescents with moderate-to-severe atopic dermatitis (eczema) who had previously been treated with dupilumab. The 86 participants received lebrikizumab injections to see if it could signi…

This large, late-stage study tested a once-daily oral medication called LY3502970 (orforglipron) to see if it could help people lose weight and better manage their type 2 diabetes. Over 1,600 adults with obesity or overweight and type 2 diabetes participated, comparing the drug t…

This early-stage study tested the safety and effects of a new drug called LY3841136, both by itself and combined with the existing weight-loss medication tirzepatide. It involved 128 Japanese adults who were living with obesity or overweight. The main goals were to check for side…

This study tested whether baricitinib, a pill taken daily, could help regrow hair in adults with severe alopecia areata, an autoimmune condition causing significant hair loss. Over 760 participants were randomly assigned to receive either a low dose, a high dose, or a placebo pil…

This study tested whether adding an experimental drug called LY2875358 to the standard treatment erlotinib works better than erlotinib alone for advanced lung cancer. It involved 168 patients whose cancer had spread and who had a specific genetic mutation. All patients started wi…

This early-stage study tested the safety and side effects of a single dose of eloralintide, an experimental weight management drug, in 30 Chinese adults with obesity or overweight. Researchers monitored participants for 10 weeks to see how their bodies handled the medication and …

This study tested a once-daily oral medication called orforglipron for adults with type 2 diabetes whose blood sugar was not well controlled on insulin. It aimed to see if the pill could lower blood sugar and body weight more effectively than a placebo over about 46 weeks. The tr…

This study tested whether an investigational drug called retatrutide could improve kidney function in people who are overweight or obese and have chronic kidney disease, with or without type 2 diabetes. The 31-week trial involved 146 participants and compared the drug's effects t…

This study tested a new daily pill called LY3502970 against an existing medication, oral semaglutide, in adults with type 2 diabetes whose blood sugar wasn't well controlled on metformin alone. It involved 1,698 participants and lasted about 61 weeks. The main goal was to see whi…

This study tested whether adding a drug called abemaciclib to standard chemotherapy is safe and effective for children and young adults whose solid tumors returned or didn't respond to other treatments. It involved 47 participants with various cancers, including neuroblastoma, an…

This study tested an experimental drug called donanemab in people with early Alzheimer's disease. The main goal was to see if the drug could safely slow down the decline in memory and daily function. Researchers enrolled 272 participants and measured changes in thinking skills an…

This study tested whether a daily pill called orforglipron helps people maintain weight they had already lost in a previous trial. It involved 376 adults with obesity or overweight who had weight-related health issues. Participants were randomly assigned to receive either the act…

This study tested the safety of Lyumjev, a fast-acting insulin, in 150 Indian adults with type 2 diabetes. Participants used the insulin for 26 weeks while researchers monitored for low blood sugar events and other side effects. The main goal was to understand how safe this insul…

This early-stage study tested a new oral drug called LY3549492 in 92 Japanese adults, including those with type 2 diabetes and healthy volunteers. The main goal was to check the drug's safety, side effects, and how the body absorbs and processes it. Researchers also looked for ea…

This study tested lebrikizumab, an injectable medication, for long-term safety and effectiveness in people with moderate-to-severe eczema (atopic dermatitis). Over 1,100 participants who had previously been in lebrikizumab studies continued treatment for up to 33 months. The rese…

This study tested a new once-daily pill called orforglipron against an existing drug, dapagliflozin, in adults with type 2 diabetes whose blood sugar was still too high on metformin. The main goal was to see which drug was better and safer at lowering blood sugar over about 46 we…

This study tested the safety of combining two weight management drugs, tirzepatide and a new drug called LY3841136, in overweight and obese adults. It involved 96 participants and lasted about 42 weeks. The main goal was to see if the combination was safe and well-tolerated, whil…

This study tested an injectable drug called lebrikizumab in 90 teens and adults with moderate-to-severe atopic dermatitis (eczema) who have skin of color. The main goal was to see how safe the drug is and how well it works to clear skin and reduce severe itching over 24 weeks. Re…

This was the first human study of an experimental cancer drug called LY3039478. Researchers tested it in 247 patients with advanced or metastatic cancer to find the highest dose that could be given safely. The study also looked for early signs that the drug might help shrink tumo…

This study tested whether mirikizumab could help people with moderate to severe ulcerative colitis maintain their improvement after initial treatment. Over 1,100 participants who had responded well to earlier treatment received either the drug or a placebo for 40 weeks. Researche…

This early-stage study tested how a new drug called orforglipron changes body fat, especially deep belly fat, in adults with obesity or overweight who do not have diabetes. It compared the drug's effects to a placebo (inactive substance) in 120 participants over about 8 months. T…

This early-stage study tested the safety and how the body processes two experimental drugs, eloralintide alone and combined with tirzepatide, for weight management. It involved 188 adults who were overweight or obese, giving weekly injections under the skin for up to 26 weeks. Re…

This early-stage study tested whether a new drug, LY3437943, could help people with obesity eat fewer calories and use energy differently while dieting. It compared the drug to a placebo in 85 participants over about six months. The main goal was to see if the drug changed how mu…

This study directly compared two injectable medications, tirzepatide and semaglutide, to see which one helps people lose more weight. It involved 751 adults who had obesity or were overweight with related health problems like high blood pressure, but who did not have diabetes. Th…

This completed Phase 2 trial tested whether adding a new drug called LY2157299 to standard lomustine chemotherapy, or using LY2157299 alone, could help people with recurrent glioblastoma brain cancer live longer compared to standard chemotherapy alone. The study involved 158 part…

This early-stage study tested the safety and side effects of an experimental drug called LY3532226 in 132 adults with obesity. Researchers gave participants either the drug or a placebo weekly or monthly and measured how much medication entered their bloodstream and how long it s…

This study tested a new connected insulin pen system to see if it helps people with type 1 or type 2 diabetes remember to take their insulin doses on time. Researchers measured how often doses were missed and tracked blood sugar control in about 36 participants. The goal was to s…

This completed Phase 2 study tested an experimental oral medication called LY3972406 in 33 adults with moderate-to-severe plaque psoriasis. The goal was to see if the pill could safely reduce the severity of skin plaques and improve patients' quality of life. Participants were ra…

This study tested an oral medication called LOXO-305 in Chinese adults with certain types of lymphoma or chronic leukemia that had returned or stopped responding to standard treatments. The main goal was to see how safe the drug was and how well it worked to control the cancer. R…

This study tested a new weekly injection called retatrutide against a placebo (dummy shot) in adults with type 2 diabetes. The goal was to see if it could better control blood sugar and help with weight loss in people whose diabetes wasn't well-managed by diet and exercise alone.…

This study tested a medication called tirzepatide in children and teenagers (ages 10-17) whose type 2 diabetes was not well-controlled with standard treatments like metformin or insulin. Over 60 weeks, researchers compared the drug to a placebo to see if it could better lower blo…

This early-stage study tested how an experimental breast cancer drug, imlunestrant, might interact with several common medications. Researchers gave imlunestrant and other drugs to 113 healthy female volunteers to see if they affect each other's levels in the body. The main goal …

This study tested how a cancer drug (selpercatinib/LOXO-292) affects how the body processes a diabetes medication (repaglinide). It involved 16 healthy adults who took both drugs to measure their levels in the blood and check for safety. The goal was to understand potential drug …

This study tested how the body absorbs and processes an experimental Alzheimer's drug called remternetug when it's given in two different ways. Researchers compared giving the drug with an easy-to-use auto-injector versus a traditional prefilled syringe in 72 healthy volunteers. …

This early-stage study tested the safety of an experimental drug called LY3876602 in 74 healthy volunteers. Researchers gave participants increasing doses to see how their bodies reacted and measured how much drug reached both the bloodstream and spinal fluid. The main goal was t…

This early-stage study tested a new drug called LY3985863 in healthy Chinese volunteers to check its safety and how the body processes it. Twenty-four participants received injections under their skin or a placebo, and researchers monitored for side effects and measured drug leve…

This early-stage study aimed to understand how the body absorbs and processes an investigational drug called LY4268989. It tested the drug's safety, how food affects it, and if it interacts with other medications. The study involved 144 healthy adult volunteers, including specifi…

This study aimed to understand how kidney problems affect the way the body processes a cancer drug called LOXO-292 (selpercatinib). Researchers compared a single dose of the drug in 37 people with varying levels of kidney function to healthy volunteers. The goal was to gather dat…

This study tested new versions of a fast-acting insulin called insulin lispro in healthy volunteers. Researchers wanted to see how quickly the body absorbs and clears these new formulations from the blood and to check their safety. The study did not treat diabetes but gathered in…

This early-stage study aimed to understand how the body absorbs, breaks down, and eliminates an experimental drug called LY4065967. It involved 16 healthy male volunteers who were tracked for about two months. Researchers measured how much of the drug entered the bloodstream and …

This study aimed to understand how a breast cancer drug, imlunestrant, is processed by the body in people with different levels of liver function. It compared the drug's levels in the blood of women with impaired livers to those with healthy livers. The goal was to gather safety …

This was an early-stage study to check the safety and how the body processes a new drug called LY3451838. It involved 53 healthy volunteers who received the drug either through an IV or an injection under the skin. The main goal was to see what side effects might occur and to mea…

This early-stage study tested a new drug called LY3522348 in healthy volunteers to check its safety and how the body processes it. Researchers gave different doses to 65 healthy adults and monitored for side effects while taking blood samples to measure drug levels. The goal was …

This was an early, first-in-human study to check the safety and basic body processing of a new, unnamed drug called LY3526318. It involved 16 healthy volunteers who took the drug by mouth, either once or multiple times. The main goals were to see how the body absorbs and eliminat…

This early-stage study aimed to understand how a single dose of an investigational drug, LY3526318, affects blood flow in the skin of healthy women. Researchers applied a cinnamon-based substance to the skin to measure changes in blood flow and tracked the drug's levels in the bo…

This study tested whether a new, larger autoinjector device delivers the drug mirikizumab into the body in the same way as the currently used, smaller device. It involved 498 healthy volunteers who received injections under the skin. The main goal was to compare how much drug get…

This study looked at how eating a high-fat meal or taking common heartburn medication affects how the body absorbs and processes an experimental cancer drug called selpercatinib. Researchers gave the drug to 20 healthy volunteers under different conditions to measure drug levels …

This early-stage study aimed to understand how the experimental drug LY4064809 is absorbed and eliminated by the body. It involved 10 healthy Chinese adults who took the drug orally and were monitored for about 21 days. The main goals were to measure drug levels in the blood and …

This early-stage study aimed to check if a new drug called LY3985297 is safe and how the body handles it. It involved 140 healthy volunteers who received either the drug or a placebo as a single shot or several shots over time. The main goal was to watch for side effects and meas…

This study tested whether a cancer drug called Selpercatinib (also known as LOXO-292) affects the heart's electrical rhythm, which is a standard safety check for new medications. It involved 32 healthy adult volunteers who received the drug and a placebo in a carefully controlled…

This early-stage study aimed to understand how the body absorbs and processes different versions of an investigational drug called bimagrumab, both by itself and when given with another drug called tirzepatide. It involved 125 healthy volunteers and lasted about 4.5 months. The m…

This early study aimed to understand how a new drug, olomorasib, is processed by people with different levels of liver impairment compared to healthy people. It involved 46 participants who received a single dose, with a focus on measuring drug levels in the blood and checking fo…

This early-stage study aimed to understand how a new breast cancer drug, imlunestrant, might affect how the body processes other medications. It involved 20 healthy women and measured how the drug changed levels of a common sedative in the blood. The main goal was to gather safet…

This study aimed to understand how a single dose of the cancer medication selpercatinib changes the amount of the cholesterol-lowering drug rosuvastatin in a person's bloodstream. It involved 28 healthy adult participants and measured drug levels and safety over about a month. Th…

This study aimed to understand how much of an experimental drug gets into the bloodstream and how the body gets rid of it. It involved 16 healthy female volunteers who could not become pregnant. Researchers gave a single dose containing a tiny, safe amount of radioactive material…

This study aimed to understand how two different capsule versions of the experimental drug olomorasib are absorbed by the body and whether taking it with food changes that absorption. It involved 191 healthy Japanese participants and lasted about six weeks. The goal was to gather…

This study tested a new drug called LY3484356 to see how it affects breast cancer tumors before surgery. Researchers gave the drug to 87 postmenopausal women with early-stage, hormone-sensitive breast cancer for a short period before their planned operation. The main goal was to …

This study aimed to understand how taking multiple doses of the cancer drug selpercatinib (LOXO-292) changes how the body processes a single dose of the sedative midazolam. It involved 16 healthy adult participants and lasted about 6 weeks. The main goal was to measure drug level…

This early study aimed to understand how eating food or taking common medications like heartburn or seizure drugs affects how the body processes a new drug called LY3484356. Researchers tested 82 healthy women who could not become pregnant, measuring drug levels in their blood an…

This study aimed to understand how two common medications, itraconazole and rifampin, affect how the body absorbs and removes the cancer drug selpercatinib. It involved 24 healthy adult participants who took selpercatinib alone and then with the other drugs. The goal was to gathe…

This early-stage study tested the safety and how the body processes lebrikizumab in healthy Chinese volunteers. Twenty-four participants received a single injection of either the drug or a placebo. Researchers monitored side effects and measured how quickly the drug entered and l…

The main purpose of this study is to evaluate the efficacy and safety of tirzepatide for the maintenance of body weight reduction.